Non-intrusive human activity sensing with radio signals. This project aims to develop a theoretical framework for sensing and detecting human activities based on wireless radio signals. The framework advances the state-of-the-art by discovering the fundamental theory, and defining a set of principles to guide practical system design. The framework will be validated and its scientific merit demonstrated through building several applications such as contactless human activity detection and vital s ....Non-intrusive human activity sensing with radio signals. This project aims to develop a theoretical framework for sensing and detecting human activities based on wireless radio signals. The framework advances the state-of-the-art by discovering the fundamental theory, and defining a set of principles to guide practical system design. The framework will be validated and its scientific merit demonstrated through building several applications such as contactless human activity detection and vital signs monitoring. This should benefit existing hospital and clinical patient services and promote home-care and self-care services at nationwide.Read moreRead less
How parents manage climate anxiety: coping and hoping for the whole family. This project studies how Australian parents manage climate anxiety for themselves and their families. Using mixed-methods/mixed-media approaches, it examines whether an increase in climate disasters is accelerating the spread of collective anxiety amongst families, how parents manage this anxiety for their children and partners, and if there are associated mental health burdens and gendered inequities in this management. ....How parents manage climate anxiety: coping and hoping for the whole family. This project studies how Australian parents manage climate anxiety for themselves and their families. Using mixed-methods/mixed-media approaches, it examines whether an increase in climate disasters is accelerating the spread of collective anxiety amongst families, how parents manage this anxiety for their children and partners, and if there are associated mental health burdens and gendered inequities in this management. It also looks at climate anxiety management across generations and climate histories, drawing out pessimistic/optimistic narratives about the future to enable action, resilience, and hope. It will produce an evidence base and photo-voice/documentary resources to help parents and support organisations combat climate anxiety.Read moreRead less
Regulation of lung immune-epithelial networks sensing environmental change. This study aims to uncover how lung epithelial cells engage with immune cells and determine their cellular and molecular wiring to ensure homeostatic maintenance and essential repair processes of lung tissues. Maintenance of lung epithelial-immune networks is essential to maintain normal lung tissue structure and function, and to induce immune responses to protect against microbial challenges or inhaled potentially toxic ....Regulation of lung immune-epithelial networks sensing environmental change. This study aims to uncover how lung epithelial cells engage with immune cells and determine their cellular and molecular wiring to ensure homeostatic maintenance and essential repair processes of lung tissues. Maintenance of lung epithelial-immune networks is essential to maintain normal lung tissue structure and function, and to induce immune responses to protect against microbial challenges or inhaled potentially toxic substances. Understanding this molecular program of epithelial-immune cell-mediated sensing/repair will be essential to understand how tissue-repair processes can be driven in the lung, an organ critical for respiration and thus life.Read moreRead less
Online and offline social networks and the development of sexual agency. This project will explore whether there exists a relationship between adolescents' social networks (both online and offline) and one important aspect of healthy sexual development - the development of sexual agency - and if so, it will investigate the nature of that relationship. The longitudinal mixed methods study proposed here aims to capture the development of sexual behaviours and the online and offline interactions ad ....Online and offline social networks and the development of sexual agency. This project will explore whether there exists a relationship between adolescents' social networks (both online and offline) and one important aspect of healthy sexual development - the development of sexual agency - and if so, it will investigate the nature of that relationship. The longitudinal mixed methods study proposed here aims to capture the development of sexual behaviours and the online and offline interactions adolescents engage in. This project aims to determine: whether there is a relationship between adolescents' online and offline social networks and the development of sexual agency; if such a relationship exists, what is its nature? And, if the relationship exists, to what extent is the relationship moderated by online social media use?Read moreRead less
The macrophage nucleus - its form and function during migration in vivo. As cells migrate through tissues, they encounter complex, 3-dimensional environments that provide cues to guide them and present obstacles in their path. This project focuses on macrophages, a large immune cell capable of both amoeboid and mesenchymal modes of migration. The nucleus is the largest organelle and its bulk and stiffness must be managed as migrating cells travel through constrictions. The project uses specialis ....The macrophage nucleus - its form and function during migration in vivo. As cells migrate through tissues, they encounter complex, 3-dimensional environments that provide cues to guide them and present obstacles in their path. This project focuses on macrophages, a large immune cell capable of both amoeboid and mesenchymal modes of migration. The nucleus is the largest organelle and its bulk and stiffness must be managed as migrating cells travel through constrictions. The project uses specialised high-end microscopy and genetic methods to examine how the nucleus of migrating zebrafish macrophages deforms, repositions and is restructured during migration in living tissues, and how this influences macrophage locomotion. The goal is to provide fundamental insights into the cell biology of macrophage migration.Read moreRead less
Nuclear plasticity during neutrophil migration and function. This project aims to discover how nuclear shape affects neutrophil function. Cell migration needs overall cellular plasticity and plasticity of internal structures such as the nucleus. The neutrophil, one of the most peripatetic cell types, has a specialised lobulated nucleus, thought to facilitate its mobility and function. Using zebrafish reporter lines that concurrently display the nucleus and cytoplasm, this project will display th ....Nuclear plasticity during neutrophil migration and function. This project aims to discover how nuclear shape affects neutrophil function. Cell migration needs overall cellular plasticity and plasticity of internal structures such as the nucleus. The neutrophil, one of the most peripatetic cell types, has a specialised lobulated nucleus, thought to facilitate its mobility and function. Using zebrafish reporter lines that concurrently display the nucleus and cytoplasm, this project will display the dynamic plasticity of neutrophil nuclei during neutrophil migration and function in vivo. This project seeks to use the spatiotemporal resolution of a lattice light sheet microscope to examine this further, and explore its effect on neutrophil function. The project seeks to establish morphological and mechanical principles applying not just to neutrophils, but to all migratory cell types.Read moreRead less
Development of cognitive functions in adult populations. Cognitive functioning has significant social, health and economic effects in the form of either benefits from improved functioning or costs due to cognitive decline. In the latter regard, an aging population presents major challenges to society. The proposed project will investigate the effects of different training regimes on cognition and a range of related outcomes, including transfer of skills, personality change and social functioning ....Development of cognitive functions in adult populations. Cognitive functioning has significant social, health and economic effects in the form of either benefits from improved functioning or costs due to cognitive decline. In the latter regard, an aging population presents major challenges to society. The proposed project will investigate the effects of different training regimes on cognition and a range of related outcomes, including transfer of skills, personality change and social functioning, on a highly innovative brain training App being developed in collaboration with the Australian Broadcasting Corporation. Read moreRead less
Elucidating the post-transcriptional regulation of mast cell proteases. Mast cells (MCs) are immune cells that protect against pathogens but may induce deleterious inflammation. MC function is mediated by specific proteases that are pre-formed and stored in granules. These proteases have unique yet poorly understood mechanisms of regulation. The aim of the project is to use a novel suite of molecular tools and genetically modified mice to identify the critical regions of transcripts that post-tr ....Elucidating the post-transcriptional regulation of mast cell proteases. Mast cells (MCs) are immune cells that protect against pathogens but may induce deleterious inflammation. MC function is mediated by specific proteases that are pre-formed and stored in granules. These proteases have unique yet poorly understood mechanisms of regulation. The aim of the project is to use a novel suite of molecular tools and genetically modified mice to identify the critical regions of transcripts that post-transcriptionally regulate the production and storage of these proteins. The project aims to identify the RNA binding proteins, microRNAs and other novel factors that also regulate them. This is expected to elucidate the post-transcriptional mechanisms of regulation of MC proteases.Read moreRead less
Developing Aboriginal Social Capital for participants not spectators in the Australian economy. If a sector of Indigenous Australians can be taught to understand financial management, resource budgeting and financial planning (personal attributes that Western society values, yet often takes for granted); it is anticipated that they will in turn seek to improve their social position and look at wealth creation to reduce their dependence in a welfare culture. These people can be educated and encou ....Developing Aboriginal Social Capital for participants not spectators in the Australian economy. If a sector of Indigenous Australians can be taught to understand financial management, resource budgeting and financial planning (personal attributes that Western society values, yet often takes for granted); it is anticipated that they will in turn seek to improve their social position and look at wealth creation to reduce their dependence in a welfare culture. These people can be educated and encouraged to be active participants within the wider Australian economy, the national and community benefit will be the development of independent citizens and the creation of social capital that is financial knowledge. Read moreRead less
Early years languages learning in Australia. This project aims to investigate early year’s language programs in Australian schools. The project will explore and analyse successful programs in the three states of NSW, Queensland and Victoria, policy, curricula and resources for languages teaching and learning, key stakeholder perspectives, and student progress in new primary language teaching degrees. The project expects to generate new knowledge of linked best practice program types, pedagogies, ....Early years languages learning in Australia. This project aims to investigate early year’s language programs in Australian schools. The project will explore and analyse successful programs in the three states of NSW, Queensland and Victoria, policy, curricula and resources for languages teaching and learning, key stakeholder perspectives, and student progress in new primary language teaching degrees. The project expects to generate new knowledge of linked best practice program types, pedagogies, and teacher requirements, to provide new data and ongoing research opportunities. Intended benefits include the education of more linguistically and culturally competent young Australians who are able to effectively engage in a plurilingual, globalised world.Read moreRead less