Understanding brain mechanisms that control autonomic function. This project aims to understand the how the brain regulates sympathetic nerve activity, thereby increasing our understanding of the biology and function of nascent neurons on the adult brain stem. This challenges the current notion that new neurons are only made during development. The project will also determine how brain inflammation impacts blood-brain barrier function and affects sympathetic nerve regulation. The basic fundament ....Understanding brain mechanisms that control autonomic function. This project aims to understand the how the brain regulates sympathetic nerve activity, thereby increasing our understanding of the biology and function of nascent neurons on the adult brain stem. This challenges the current notion that new neurons are only made during development. The project will also determine how brain inflammation impacts blood-brain barrier function and affects sympathetic nerve regulation. The basic fundamental insights and conceptual advances into how autonomic function is controlled by the brain will provide a better understanding of these fundamental processes and will contribute to Australia’s priority research areas to improve health and advance product development.Read moreRead less
From rehabilitation to recovery after stroke : a model to optimise consumer and carer involvement. The National Research Priorities include 'ageing well, ageing productively'. Within this priority, it is necessary to be inclusive of those who have ongoing disabilities and/or chronic disease. This project aims to facilitate healthy lifestyles and community involvement in a group who have significant barriers to achieving their potential. The high incidence of depression and poor quality of life i ....From rehabilitation to recovery after stroke : a model to optimise consumer and carer involvement. The National Research Priorities include 'ageing well, ageing productively'. Within this priority, it is necessary to be inclusive of those who have ongoing disabilities and/or chronic disease. This project aims to facilitate healthy lifestyles and community involvement in a group who have significant barriers to achieving their potential. The high incidence of depression and poor quality of life in stroke survivors and their carers emphasises the need to enhance wellness in these people. The study will develop a model for promoting recovery and community reintegration in stroke survivors, with the goal of enabling stroke survivors and their carers to actively participate in the community and pursue personal goals.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE180101075
Funder
Australian Research Council
Funding Amount
$365,058.00
Summary
Novel immune cell subsets in the centre nervous system and supporting tissues. This project aims to identify and characterise novel resident immune cell subsets within the brain and retina, and their close supporting tissues. The project expects to generate new knowledge in the areas of neuroimmunology and ocular immunology by using molecular and cellular techniques to examine the diversity of immune cells within the brain and retina. It is expected that the project will advance our understandin ....Novel immune cell subsets in the centre nervous system and supporting tissues. This project aims to identify and characterise novel resident immune cell subsets within the brain and retina, and their close supporting tissues. The project expects to generate new knowledge in the areas of neuroimmunology and ocular immunology by using molecular and cellular techniques to examine the diversity of immune cells within the brain and retina. It is expected that the project will advance our understanding of the biological mechanisms that protect the central nervous system from harmful inflammation and thus improve our knowledge of the immunobiology of the brain and eye.Read moreRead less
The role of P2X7 and P2X4 receptor mediated innate phagocytosis in pathogenesis and treatment of neurodegenerative diseases. This project will identify how inherited variation in two proteins of the brain can accelerate the removal of neurones and predispose to a range of neurodegenerative diseases. Knowledge of the biological basis of this finding will allow a search for new compounds which will slow and protect against this form of neurodegeneration.
Investigating the role of the innate immune complement system in the abnormal development of the central nervous system. Past research has discovered a surprising link between the immune system, dietary folate deficiency and the development of the embryonic brain. This project will investigate the immune system in the developing brain, in order to understand the causes of developmental defects such as neural tube defects, and the role dietary folate plays in this process.