Virus and host genes and the outcome of infection. Viruses cause infection of all animals including people and the outcome of infection is highly variable. This project aims to use genetics to explain why some animals are more susceptible to particular virus infections and some strains of virus cause more severe diseases. The project will also explore whether all cells are similarly susceptible to killing by viruses.
Evolution of immunoregulatory networks: preventing autoimmunity at the expense of perpetuating chronicity in persistent infections. Chronic pathogens like HIV take advantage of human genes that regulate immune responses, which evolved to prevent autoimmunity, enabling them to evade eradication. This project defines the nature and interplays between these genes and will provide valuable clues as to how immunity can be manipulated to promote clearance of persistent infections.