Centre Of Research Excellence On Sitting Time And Chronic Disease Prevention – Mechanisms, Measurement And Interventions
Funder
National Health and Medical Research Council
Funding Amount
$2,657,874.00
Summary
Australian research has identified serious health consequences arising from the 7 to 10 hours of daily sitting that most people do, especially in relation to ‘diseases of inactivity’ – type 2 diabetes, coronary heart disease and breast and colon cancer – that are an unwelcome burden on individuals, families and health systems. This new research examines the practical feasibility and the preventive-health benefits of changing children’s and adults’ sitting time in schools, workplaces and the home ....Australian research has identified serious health consequences arising from the 7 to 10 hours of daily sitting that most people do, especially in relation to ‘diseases of inactivity’ – type 2 diabetes, coronary heart disease and breast and colon cancer – that are an unwelcome burden on individuals, families and health systems. This new research examines the practical feasibility and the preventive-health benefits of changing children’s and adults’ sitting time in schools, workplaces and the home environment.Read moreRead less
Sitting Less And Moving More: Population Health Research To Understand And Influence Sedentary Behaviour
Funder
National Health and Medical Research Council
Funding Amount
$6,367,518.00
Summary
The majority of Australian adults spend most of their waking hours sitting: at home, at work, and in their cars; most do not participate in exercise or sport. This leads to weight gain and to diseases of inactivity (particularly diabetes, heart disease, cancer and depression). New research will measure sitting time and the physical activity in people's daily lives, what factors encourage inactivity, and how to increase activity levels, especially among the ageing 'baby boomer' population.
Imaging the world of miniature venomous arthropods. Venomous arthropods produce a myriad of biologically active peptides, with many having potential as pharmacological tools, bioinsecticides and pharmaceuticals. Most studies to date have focussed on large arthropods; smaller species remain neglected due to the difficulties of venom collection. This project seeks to further advance the pioneering imaging mass spectrometry approaches the project team developed for imaging toxins in the venom gland ....Imaging the world of miniature venomous arthropods. Venomous arthropods produce a myriad of biologically active peptides, with many having potential as pharmacological tools, bioinsecticides and pharmaceuticals. Most studies to date have focussed on large arthropods; smaller species remain neglected due to the difficulties of venom collection. This project seeks to further advance the pioneering imaging mass spectrometry approaches the project team developed for imaging toxins in the venom glands of spiders and centipedes. By combining high-resolution matrix-assisted laser desorption ionisation imaging data with histological and transcriptomic information the project aims to provide the first detailed insights into the neglected world of miniature arthropod venoms. The approaches developed by this project aim to have wide application in the field of biology.Read moreRead less
Pharmacology Of Potential Anti-Tumour Agents: Iron Chelators Of The BpT Class
Funder
National Health and Medical Research Council
Funding Amount
$585,455.00
Summary
Pharmacology of Potential Anti-Tumour Agents: Iron Chelators of the BpT Class Cancer cells have a high iron requirement for DNA synthesis and many clinical trials showed Fe chelators are effective anti-cancer drugs. Their potential to act as anti-tumour agents has been confirmed by the entrance of Triapine into widespread NCI clinical trials. In this NHMRC Renewal, we will perform pharmacological and preclinical studies to promote the development of BpT chelators as novel anti-tumour agents.
TELEPHONE COUNSELLING FOR MAINTENANCE OF PHYSICAL ACTIVITY, WEIGHT LOSS And GLYCAEMIC CONTROL IN TYPE 2 DIABETES
Funder
National Health and Medical Research Council
Funding Amount
$1,285,894.00
Summary
Regular exercise, a healthy diet and weight loss are key to managing type 2 diabetes, yet these are major challenges for most people with diabetes. This study will evaluate the impact of a telephone counselling program to assist people with type 2 diabetes to exercise, eat a healthy diet and lose weight, with the goal of helping them to sustain these changes over the long-term. It is expected that these lifestyle changes will also result in improved blood glucose control and quality of life.
Reducing Prolonged Workplace Sitting Time In Office Workers: A Cluster-randomised Controlled Trial
Funder
National Health and Medical Research Council
Funding Amount
$524,613.00
Summary
Groundbreaking Australian research shows that sitting for too long, which is routine for most office workers, contributes to overweight and to a greater risk of developing diabetes and heart disease. In over 300 desk-bound office workers, this world-first study will assess the effectiveness of an innovative workplace program aimed at reducing and breaking up sitting time. It will identify practical ways for Australian office workers to minimise unhealthy effects of sitting too much at work.