Dopamine Neuron Ontogeny: Convergent Neurobiological Pathway For Risk Factors Of Schizophrenia
Funder
National Health and Medical Research Council
Funding Amount
$337,214.00
Summary
Schizophrenia is associated with changes in dopamine (a signalling molecule in the brain). These changes are present prior to psychosis, suggesting they begin early in development. Our aims are to manipulate key factors in the development of brain dopamine systems to clarify their role in psychosis and schizophrenia. This work has the potential to identify early brain changes that lead to schizophrenia, which in turn may generate better diagnoses and outcomes for people with this disorder.
Discovery Early Career Researcher Award - Grant ID: DE240100269
Funder
Australian Research Council
Funding Amount
$448,117.00
Summary
Maintaining Human Expertise in an AI-driven World. While information systems with artificial intelligence are increasingly used to support or automate work tasks, this can come at a cost to the development and retention of essential skills in workers. Skill erosion can jeopardise safety and fairness in contexts where humans' skills are needed. This innovative project leverages systems thinking, case studies and action design research to investigate how leveraging artificial intelligence shapes w ....Maintaining Human Expertise in an AI-driven World. While information systems with artificial intelligence are increasingly used to support or automate work tasks, this can come at a cost to the development and retention of essential skills in workers. Skill erosion can jeopardise safety and fairness in contexts where humans' skills are needed. This innovative project leverages systems thinking, case studies and action design research to investigate how leveraging artificial intelligence shapes workers' skills. Its expected outcomes include a new systems theory of skill erosion and organisational guidelines for managing artificial intelligence. These can help organisations maximise human potential by striking a balance between relying on automation and maintaining workers' skills. Read moreRead less
High Penetrance Deleterious Mutations In Blinding Glaucoma
Funder
National Health and Medical Research Council
Funding Amount
$1,345,055.00
Summary
This project aims to identify the genes most commonly mutated in individuals with advanced glaucoma. Identification of such genes will lead to improved understanding of glaucoma pathogenesis, a better ability to predict risk, and the identification of drug targets for novel therapies.
Discontinued Use of Social Media: Dichotomy of Rational & Emotional Choices. This project aims to gain a better understanding of discontinued use of social media. For businesses and governments, social media serves as a dynamic channel for engagement, value co-creation, and business analytics marketing that is lost when users choose to discontinue its use. This project will generate new knowledge of rational and emotional decision criteria, enabling design features of social media, and their com ....Discontinued Use of Social Media: Dichotomy of Rational & Emotional Choices. This project aims to gain a better understanding of discontinued use of social media. For businesses and governments, social media serves as a dynamic channel for engagement, value co-creation, and business analytics marketing that is lost when users choose to discontinue its use. This project will generate new knowledge of rational and emotional decision criteria, enabling design features of social media, and their complex effects on discontinued use of social media. The expected outcome of this project is an integrated theory of social media discontinuance. The project findings provide significant benefits, such as strategic capabilities and actionable knowledge for businesses and governments to mitigate social media discontinued use.Read moreRead less
Delineating The Relationship Between Iron And Peroxisomal Disorders: The Role Of The Peroxisomal Enzyme GNPAT In Iron-Overload Disorders
Funder
National Health and Medical Research Council
Funding Amount
$700,767.00
Summary
Hereditary haemochromatosis is one of the most common genetic disorders in humans, affecting 1 in 200 Australians. We have identified a change in a peroxisomal gene which may affect iron levels in humans. The prevalence of this gene change in Australian haemochromatosis patients will be examined followed by a systematic analysis of how this protein controls iron levels in the body. Our goal is to identify and diagnose genetic changes which influence iron loading in haemochromatosis patients.
Governance of Agile Software Development Projects. The aim of the project is to generate theoretical knowledge on how to govern agile teams effectively. Effective governance of software development projects is essential for companies to protect their information technology investments. Nowadays, companies have migrated to agile software development where requirements and solutions evolve iteratively and change frequently; yet formal approaches to governance (eg steering committee and detailed pl ....Governance of Agile Software Development Projects. The aim of the project is to generate theoretical knowledge on how to govern agile teams effectively. Effective governance of software development projects is essential for companies to protect their information technology investments. Nowadays, companies have migrated to agile software development where requirements and solutions evolve iteratively and change frequently; yet formal approaches to governance (eg steering committee and detailed plans) are ineffective and impede flexibility, agility and creativity. This project aims to identify informal governance approaches for agile projects based on team embeddedness and network theory. With this knowledge, management could ensure projects deliver value at an acceptable cost, quality and timescale.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE220101597
Funder
Australian Research Council
Funding Amount
$360,264.00
Summary
Empowering Users to Protect their Personal Privacy on Social Media. This Information Systems project aims to take a bold approach to finally overcome the paradoxical inertia of people who care about their privacy but do not protect it. This project integrates different psychological theories proposing a paradigm shift expecting to generate new knowledge in privacy research, which can currently neither explain nor provide means to overcome the vexing issue. Expected outcomes of the project includ ....Empowering Users to Protect their Personal Privacy on Social Media. This Information Systems project aims to take a bold approach to finally overcome the paradoxical inertia of people who care about their privacy but do not protect it. This project integrates different psychological theories proposing a paradigm shift expecting to generate new knowledge in privacy research, which can currently neither explain nor provide means to overcome the vexing issue. Expected outcomes of the project include a privacy behaviour model (PIM), privacy training program and system design solutions. This should offer substantial benefits as it integrates privacy research and guides behavioural models beyond Information Systems, provide means to solve the paradox, guide legislation and the privacy consent mechanism design.Read moreRead less
Computational modelling of nanofluids for industrial applications. The use of nanoparticles in heat transfer fluids, then known as nanofluids, increases their specific heat and thermal conductivity. Recent experimental works highlight that anomalous transport phenomena are evident in nanofluids that cannot be adequately described by classical conservation laws. We will extend these conservation laws to incorporate fractional operators to capture the fluid memory effects and the impact of particl ....Computational modelling of nanofluids for industrial applications. The use of nanoparticles in heat transfer fluids, then known as nanofluids, increases their specific heat and thermal conductivity. Recent experimental works highlight that anomalous transport phenomena are evident in nanofluids that cannot be adequately described by classical conservation laws. We will extend these conservation laws to incorporate fractional operators to capture the fluid memory effects and the impact of particle clustering. Computational modelling and experimental investigations will be undertaken to identify the heat transfer mechanisms of various nanofluids. The outcomes of the work will increase knowledge on nanofluids and offer a significant opportunity to improve the efficiency of many thermal engineering systems.Read moreRead less
The recirculation of myeloid dendritic cells. This project aims to understand dendritic cell recirculation. It will use virological tools to track dendritic cell migration, and identify key decision points. Expected outcomes include enhanced capacity in basic research and greater interdisciplinary collaboration between virology and immunology research groups. Significant benefits will include a new understanding of how G protein coupled receptor signalling and other tissue cues guide dendritic c ....The recirculation of myeloid dendritic cells. This project aims to understand dendritic cell recirculation. It will use virological tools to track dendritic cell migration, and identify key decision points. Expected outcomes include enhanced capacity in basic research and greater interdisciplinary collaboration between virology and immunology research groups. Significant benefits will include a new understanding of how G protein coupled receptor signalling and other tissue cues guide dendritic cell recirculation, and what consequences the recirculation has for immune cell function. This understanding will significantly advance our basic understanding of the immune system.Read moreRead less