Combating Bacterial ‘superbugs‘ By Innovative Dosing Strategies That Combine Available Antibiotics To Prevent Resistance
Funder
National Health and Medical Research Council
Funding Amount
$547,694.00
Summary
As resistant bacterial ‘superbugs’ are among the 3 most serious threats to global health and as new antibiotics are lacking, innovative strategies to prevent bacterial resistance are urgently needed. This proposal will yield molecular insights on optimal combinations of current beta-lactam antibiotics to maximise bacterial killing without resistance. This project will provide guidance to physicians on how to optimally combine available beta-lactam antibiotics to prevent bacterial resistance.
Substance abuse is a significant social and economic burden upon Australian societies and on societies around the world. Treatment remains problematic due to the multi-layer nature of the disease, difficulties with treatment compliance and less than ideal treatment regimes. The present study aims to improve treatments for alcohol and drug abuse using pre-clinical models to identify and characterize a new brain system implicated in drug-seeking.
High Penetrance Deleterious Mutations In Blinding Glaucoma
Funder
National Health and Medical Research Council
Funding Amount
$1,345,055.00
Summary
This project aims to identify the genes most commonly mutated in individuals with advanced glaucoma. Identification of such genes will lead to improved understanding of glaucoma pathogenesis, a better ability to predict risk, and the identification of drug targets for novel therapies.
Functional state observers for large-scale interconnected systems. This project will produce conceptual advances with new design rules to develop robust and efficient functional state observers for interconnected systems. The outcomes will advance the theory of functional observers and improve the operation, efficiency and performance of critical infrastructure such as power grids, water and traffic networks.
Salt (sodium) is an essential electrolyte. Our convincing and complementary findings provide compelling evidence for a link between evolutionarily ancient “instincts” and substance abuse. This proposal is translational, including studies in opiate dependent humans. Our studies will establish how and where in the brain endogenous opioids are implicated in the gratification of salt appetite, how salt appetite is altered in opiate dependency and if salt appetite recovers following opiate withdrawal
System identification of microstructure in the brain using magnetic resonance. Magnetic Resonance Imaging technologies will be exploited to probe the microstructure of the brain, using powerful Bayesian optimisation techniques and innovative uses of magnetic resonance. The project will in particular develop non-invasive imaging methods to quantify iron content in the brain, important for research on dementia and Alzheimer's disease.
Computational modelling of nanofluids for industrial applications. The use of nanoparticles in heat transfer fluids, then known as nanofluids, increases their specific heat and thermal conductivity. Recent experimental works highlight that anomalous transport phenomena are evident in nanofluids that cannot be adequately described by classical conservation laws. We will extend these conservation laws to incorporate fractional operators to capture the fluid memory effects and the impact of particl ....Computational modelling of nanofluids for industrial applications. The use of nanoparticles in heat transfer fluids, then known as nanofluids, increases their specific heat and thermal conductivity. Recent experimental works highlight that anomalous transport phenomena are evident in nanofluids that cannot be adequately described by classical conservation laws. We will extend these conservation laws to incorporate fractional operators to capture the fluid memory effects and the impact of particle clustering. Computational modelling and experimental investigations will be undertaken to identify the heat transfer mechanisms of various nanofluids. The outcomes of the work will increase knowledge on nanofluids and offer a significant opportunity to improve the efficiency of many thermal engineering systems.Read moreRead less
The recirculation of myeloid dendritic cells. This project aims to understand dendritic cell recirculation. It will use virological tools to track dendritic cell migration, and identify key decision points. Expected outcomes include enhanced capacity in basic research and greater interdisciplinary collaboration between virology and immunology research groups. Significant benefits will include a new understanding of how G protein coupled receptor signalling and other tissue cues guide dendritic c ....The recirculation of myeloid dendritic cells. This project aims to understand dendritic cell recirculation. It will use virological tools to track dendritic cell migration, and identify key decision points. Expected outcomes include enhanced capacity in basic research and greater interdisciplinary collaboration between virology and immunology research groups. Significant benefits will include a new understanding of how G protein coupled receptor signalling and other tissue cues guide dendritic cell recirculation, and what consequences the recirculation has for immune cell function. This understanding will significantly advance our basic understanding of the immune system.Read moreRead less
International students in secondary schools. This longitudinal project aims to analyse the forms and effects of international secondary students’ transnational connectedness with different people and places in physical and online environments. It plans to examine how and why students’ relationships change across Years 10–12 of school, and the implications for students’ experience of school, Australia, and post-school pathways. The findings may provide the empirical knowledge and theoretical insi ....International students in secondary schools. This longitudinal project aims to analyse the forms and effects of international secondary students’ transnational connectedness with different people and places in physical and online environments. It plans to examine how and why students’ relationships change across Years 10–12 of school, and the implications for students’ experience of school, Australia, and post-school pathways. The findings may provide the empirical knowledge and theoretical insights to support the development of policies and practices to support international school students, protect their social, emotional and physical wellbeing, and improve the economic competitiveness of Australia’s international education sector.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE140100620
Funder
Australian Research Council
Funding Amount
$395,220.00
Summary
Inference, control and protection of interdependent spatial networked structures. Networked structures are everywhere and modern societies largely depend on their proper functioning. Some of these networks are spatial with each node having a geographical tag. Examples include power grids, the internet and transportation networks. These networks are often interdependent where their functioning depends on each other. This project will establish a mathematical framework to efficiently observe and c ....Inference, control and protection of interdependent spatial networked structures. Networked structures are everywhere and modern societies largely depend on their proper functioning. Some of these networks are spatial with each node having a geographical tag. Examples include power grids, the internet and transportation networks. These networks are often interdependent where their functioning depends on each other. This project will establish a mathematical framework to efficiently observe and control interdependent spatial networks and develop design strategies in order to maximise residency of spatial networks against catastrophic failures in their components. The outcomes of the project will protect the Australian power grid and transportation networks against random and intentional failures. Read moreRead less