Media Formulations To Enhance Embryo Formation In Assisted Reproduction
Funder
National Health and Medical Research Council
Funding Amount
$660,133.00
Summary
The increasing age of parenthood has led to an explosion in the demand for assisted reproductive technologies such as in vitro fertilisation (IVF). This procedure has a poor success rate and is limited by the ability of fertilised eggs to mature into early embryos in the lab prior to being transferred into women. We will develop new compounds that improve embryo growth in the clinic, which will improve IVF success rates.
Nicotinamide Adenine Dinucleotide (NAD+)-raising Agents For Improving Oocyte Quality
Funder
National Health and Medical Research Council
Funding Amount
$445,827.00
Summary
Many women cannot have children because of suboptimal egg quality, often due to aging. Currently, the only option is to use better quality eggs donated from another woman. This project will use pharmacological agents to promote recently discovered pathways in eggs central to determining quality. Importantly, we will investigate a simple and practical approach that can be used in clinics for augmenting these pathways to improve oocyte quality for the first time.
I am a cancer cell biologist investigating molecular mechanisms of leukaemia cell resistance to chemotherapeutic drugs, and novel strategies for the management of high risk or relapsed disease. For these purposes I have developed orthotopic xenograft mode
Discovery Early Career Researcher Award - Grant ID: DE170100787
Funder
Australian Research Council
Funding Amount
$331,000.00
Summary
Misspecification in models of economic behaviour. This project aims to develop a robust method for estimation and inference with misspecified economic models. Economic models are designed to test hypotheses about economic behaviour and to estimate key parameters, but their validity and accuracy critically depend on the assumption that the model is correctly specified, which is often doubtful. This project will reparametrize the model to allow for misspecification. The project aims to help modell ....Misspecification in models of economic behaviour. This project aims to develop a robust method for estimation and inference with misspecified economic models. Economic models are designed to test hypotheses about economic behaviour and to estimate key parameters, but their validity and accuracy critically depend on the assumption that the model is correctly specified, which is often doubtful. This project will reparametrize the model to allow for misspecification. The project aims to help modellers produce results that better inform decision-makers and help them make more reliable decisions.Read moreRead less
Evaluation Of Molecular Mechanisms Driving Metastasis Using Integrated Intravital Imaging
Funder
National Health and Medical Research Council
Funding Amount
$885,271.00
Summary
Metastasis is the leading cause of cancer-associated death. Understanding key steps that drive the spread of cancer is critical to improve current treatment strategies. Using cutting-edge imaging technology and 3-dimensional model systems that mimic the disease, we will pinpoint key events that are susceptible to drug intervention and identify new therapeutic targets.
Oceanic gateways: a primary control on global climate change? The opening and closing of oceanic gateways, narrow passageways facilitating exchange between ocean basins, has been linked to major changes in Earth’s climate. This project will link the disparate fields of geodynamics and palaeo-climatology, for the first time, through an innovative methodology that models the changing width and depth of ocean gateways through time. It will address the role of gateways in modulating Earth’s climate ....Oceanic gateways: a primary control on global climate change? The opening and closing of oceanic gateways, narrow passageways facilitating exchange between ocean basins, has been linked to major changes in Earth’s climate. This project will link the disparate fields of geodynamics and palaeo-climatology, for the first time, through an innovative methodology that models the changing width and depth of ocean gateways through time. It will address the role of gateways in modulating Earth’s climate at key periods during the planet’s transition from a “Greenhouse” to “Icehouse” World.Read moreRead less
The Effects Of Estrogen-Responsive B Box Protein On Retinoid Sensitivity In Cancer And Its Significance In Development
Funder
National Health and Medical Research Council
Funding Amount
$82,421.00
Summary
Although effective, many cancer drugs often lead to side effects, especially in children. New therapies are needed that specifically target cancer cells while leaving normal cells unaffected. I am studying a novel protein (EBBP) which I believe has an important role in cancer cell growth. By studying EBBP I aim to be able to increase the effectiveness of the low toxic chemotherapy retinoic acid without increased side effects, as well as understand the functional role of EBBP in cancer cells.
Eddy-resolving global ocean-sea ice modelling. Eddy-resolving global ocean-sea ice modelling. This project aims to develop a world-class global ocean-sea ice model framework through a nationwide consortium. The resulting high resolution models are expected to provide the foundation for the next decade of Australian ocean-sea ice modelling capacity. This research should lead to improved ocean and sea ice prediction, ocean reanalyses, and climate projections, enhancing Australia's capacity to pred ....Eddy-resolving global ocean-sea ice modelling. Eddy-resolving global ocean-sea ice modelling. This project aims to develop a world-class global ocean-sea ice model framework through a nationwide consortium. The resulting high resolution models are expected to provide the foundation for the next decade of Australian ocean-sea ice modelling capacity. This research should lead to improved ocean and sea ice prediction, ocean reanalyses, and climate projections, enhancing Australia's capacity to predict the ocean state on timescales of days to decades. This is expected to yield efficiencies in shipping, marine search and rescue and naval operations, and increase the accuracy of projected future changes in climate, sea level, ocean ecosystems and the cryosphere.Read moreRead less
Australian housing market risks: Simulation, modelling and analysis. This project aims to determine whether the Australian housing market is at risk of a collapse. This project aims to model the systemic risks in this market using an agent-based simulation at the individual household and financial decision-maker levels. This will be achieved by combining simulation software with datasets from the Australian Bureau of Statistics, Census data and mortgage markets into a behavioural model of financ ....Australian housing market risks: Simulation, modelling and analysis. This project aims to determine whether the Australian housing market is at risk of a collapse. This project aims to model the systemic risks in this market using an agent-based simulation at the individual household and financial decision-maker levels. This will be achieved by combining simulation software with datasets from the Australian Bureau of Statistics, Census data and mortgage markets into a behavioural model of financial decisions. This is expected to provide an unprecedented ability to economically zoom in and out on different suburbs, cities and regions across Australia to predict, measure and mitigate systemic risks.Read moreRead less
Estimating the effects of fiscal policy. This project will develop highly flexible models for estimating the effects of fiscal policy, as well as providing insight into how economic assumptions affect these estimates and which assumptions are supported by historical experience. The models and estimates will be useful for researchers, policymakers and businesses.