Resilience In Individuals And Families Coping With The Impacts Of Alcohol Related Injuries In Remote Indigenous Communities: A Program Of Mixed Method Research
Funder
National Health and Medical Research Council
Funding Amount
$316,449.00
Summary
Alcohol Management Plans (AMPs) implemented by the Queensland Government a decade ago (2002-03), primarily to control alcohol availability in Indigenous communities, are currently under review. AMPs seemed to have a number of positive effects on injury rates related to alcohol use, however a paucity of rigorous data related to injuries is currently available. An in-depth study of alcohol related injury and resilience linked to alcohol injuries in four Indigenous communities will be conducted.
Evaluation Of Alcohol Management Plans (AMPs), Cape York, North Queensland
Funder
National Health and Medical Research Council
Funding Amount
$626,395.00
Summary
The study will describe long-term impacts on important health and social outcomes of restricting alcohol in Cape York, Queensland. It will assess the impacts and cost-effectiveness of the Queensland Government’s Alcohol Management Plans implemented from 2002-03. The researchers will use de-identified data on injury, violence, health and social indicators. The study will map whether AMP components were delivered as promised and the extent to which they were welcomed by Cape York communities.
Generation Of Protective Immunity Against Severe Influenza Disease In Indigenous Australians
Funder
National Health and Medical Research Council
Funding Amount
$1,630,970.00
Summary
Hospitalisation and death rates from influenza are high in the Indigenous population, especially when a new virus emerges. There is an urgent need for a vaccine that protects against all influenza strains. T cells recognising conserved viral regions elicit such protection. As T cells are restricted by proteins called HLAs, which vary across ethnicities, we will define T cell regions for HLAs prominent in Indigenous Australians and define how to generate protective immunity against influenza.
Sequencing Periodontal Bacteria To Determine The Relationship Between Periodontits, Renal And Vascular Function Among Indigenous Australian Adults With Chronic Kidney Disease
Funder
National Health and Medical Research Council
Funding Amount
$329,644.00
Summary
Almost 20% of Indigenous Australian adults exhibit signs of kidney disease. This study will investigate the relationship between sub-gingival (below the gum) bacteria and both kidney and artery function among Indigenous Australian participants with chronic kidney disease. Using an RCT design, the proposed study will investigate whether changes in sub-gingival bacteria and concentration following conventional treatment of periodontitis align with improvements in renal and vascular function.
Understanding Influenza-specific T Cell Immunity In The Indigenous Population
Funder
National Health and Medical Research Council
Funding Amount
$870,112.00
Summary
Hospitalisation and death rates from influenza are high in the Indigenous population. There is an urgent need for one-shot universal vaccine that protects against seasonal and pandemic strains. T cells recognising conserved viral regions can elicit such protection. As T cells are restricted by proteins called HLAs, variable between different ethnicities, we will define T cell regions and their HLA restrictions in the Indigenous population to propose strategies for universal T cell-based protecti ....Hospitalisation and death rates from influenza are high in the Indigenous population. There is an urgent need for one-shot universal vaccine that protects against seasonal and pandemic strains. T cells recognising conserved viral regions can elicit such protection. As T cells are restricted by proteins called HLAs, variable between different ethnicities, we will define T cell regions and their HLA restrictions in the Indigenous population to propose strategies for universal T cell-based protective immunity and vaccine design against influenza.Read moreRead less
Prevention Of Otitis Media With Probiotics In Indigenous Children
Funder
National Health and Medical Research Council
Funding Amount
$100,531.00
Summary
The project is searching for ‘good’ bacteria in the upper airways of Aboriginal and Torres Strait Islander (A&TSI) children that have the ability to inhibit the growth of bacteria that causes middle ear disease. These ‘good’ bacteria constitute a possible probiotic and will be matched to commercially available probiotic strains. These probiotic strains will then be used to recolonise the upper airways of A&TSI children to determine whether we can reduce the recurrence of middle ear disease.
Healing The Past By Nurturing The Future: Learning How To Identify And Support Indigenous Parents Who Have Experienced Complex Childhood Trauma
Funder
National Health and Medical Research Council
Funding Amount
$1,193,719.00
Summary
Complex childhood trauma causes profound and long-lasting effects on physical, social and emotional wellbeing, which can be triggered during the transition to parenthood and impede the capacity of parents to nurture their children. The transition offers a unique opportunity for healing and preventing intergenerational transmission of trauma. This project co-designs and evaluates acceptability and feasibility of screening and support for Indigenous parents experiencing complex trauma.
Understanding Immunity To Influenza Viruses In The Indigenous Population
Funder
National Health and Medical Research Council
Funding Amount
$340,512.00
Summary
Hospitalization rates and mortality from influenza are greatly increased in the Indigenous Australian population. As current vaccines are highly strain-specific, there is an urgent need for a one-shot universal vaccine that protects this vulnerable group against seasonal and pandemic influenza. Immunity provided by T cells is long-lasting, cross-protective and can prevent severe disease. Our findings will inform the design of effective T cell-based influenza vaccines for Indigenous populations.
Reducing Disparities In Cervical Cancer Incidence For Aboriginal And Torres Strait Islander Women Through Screening And Vaccination
Funder
National Health and Medical Research Council
Funding Amount
$329,768.00
Summary
This program of research will aim to reduce cervical cancer incidence for Indigenous women by developing and trialling health systems interventions to increase cervical screening participation and HPV vaccination coverage. This research will be led by an Indigenous researcher with Indigenous people and for Indigenous people.