A Novel Intervention Targeting Insomnia To Prevent Major Depressive Disorder In The Community
Funder
National Health and Medical Research Council
Funding Amount
$1,258,316.00
Summary
In this project we want to see if we can prevent depression by improving insomnia. We will invite people with elevated depression symptoms to undertake a novel self help program to reduce insomnia, and then see if their risk for developing clinical depression is reduced 9 and 18 months later. As far as we know, this approach has not previously been tried. The merit of the project is that we have tangible symptoms (sleep problems) with which to engage individuals in a prevention strategy.
Hyper-sensitivity Of The Circadian System To Light In Delayed Sleep Phase Disorder
Funder
National Health and Medical Research Council
Funding Amount
$378,858.00
Summary
Delayed Sleep Phase Disorder (DSPD) is a circadian rhythm sleep disorder characterized by a difficulty in initiating sleep at night and difficulty in waking at times required for work or school. It is associated with excessive daytime sleepiness, reduced academic and work performance, increased anxiety and depression and reduced quality of life. This study examines increased sensitivity of the brain's 24-hour biological clock to light as a cause of the abnormal timing of sleep in DSPD.
Randomised Sham-controlled Trial Of Acupuncture For Post-menopausal Hot Flushes
Funder
National Health and Medical Research Council
Funding Amount
$499,828.00
Summary
This clinical trial will test whether needle acupuncture is more effective than a sham needle control acupuncture in relieving post-menopausal women's hot flush symptoms.
Researching Effective Sleep Treatments (Project REST): A Partner-Assisted Intervention To Improve Adherence In Cognitive Behavioural Therapy For Insomnia
Funder
National Health and Medical Research Council
Funding Amount
$1,130,307.00
Summary
Insomnia is highly prevalent and predicts many other mental and physical problems. While very good behavioural treatments exist for insomnia, not everyone is able to comply with the difficult behaviour changes required to improve. Bed partners often influence sleep behaviours, and thus, can play a helpful role in the treatment of insomnia, if they are taught how. We will test the first intervention ever developed integrating the partner into insomnia treatment as a means of improving outcomes.
Melatonin For Initial Insomnia In Stimulant-treated Pediatric ADHD
Funder
National Health and Medical Research Council
Funding Amount
$590,373.00
Summary
Does melatonin work for children with ADHD and initial insomnia? We will study children with ADHD and initial insomnia using N-of-1 trials. This is a trial in a single person, which allows them the opportunity to learn if melatonin is effective for them.We will compare the usual clinical trials (RCTs, which do not give individual results) with combined results from all the 270 patients who have done N-of-1 trials. Data from the first part of each person’s n-of-1 trial will form the RCT.
Treating Insomnia Co-morbid With Obstructive Sleep Apnoea: A Randomized Controlled Clinical Effectiveness Trial.
Funder
National Health and Medical Research Council
Funding Amount
$600,869.00
Summary
Obstructive Sleep Apnoea (OSA) is a common but serious sleep disorder. Continuous positive airways pressure (CPAP) therapy can be very effective in treating OSA. We have found that many patients with OSA also suffer from insomnia, and this can make it hard for them to begin CPAP therapy and hard for them to stick to it. This trial will examine the effect of treating insomnia concurrently with CPAP, with the expectation that overall treatment outcomes will improve.
Randomised Controlled Trial Of Melatonin For Delayed Sleep Phase Disorder
Funder
National Health and Medical Research Council
Funding Amount
$711,136.00
Summary
Delayed Sleep Phase Disorder (DSPD) is a sleep disorder affecting 7-16% of adolescents and young adults. It is associated with poor health and impaired academic and social functioning. We will test in a randomised controlled trial whether the hormone melatonin can be used as a treatment for DSPD. We will also assess whether genetic factors are linked to treatment outcome. The study will provide a much-needed standardised diagnostic and treatment approach for DSPD.