EGF Peptide Signalling Improves Oocyte Maturation And Quality
Funder
National Health and Medical Research Council
Funding Amount
$586,891.00
Summary
Infertility is common and although IVF is widely accepted, the procedure is expensive and is associated with health risks. Using laboratory animals, we have developed significant new insights into mechanisms regulating egg quality. These insights have allowed us to develop a new approach to infertility treatment - crucially, one that eliminates the need for ovarian hormone therapy used in IVF. This project will investigate the basic mechanisms underlying our new approach to enable safe clinical ....Infertility is common and although IVF is widely accepted, the procedure is expensive and is associated with health risks. Using laboratory animals, we have developed significant new insights into mechanisms regulating egg quality. These insights have allowed us to develop a new approach to infertility treatment - crucially, one that eliminates the need for ovarian hormone therapy used in IVF. This project will investigate the basic mechanisms underlying our new approach to enable safe clinical implementation.Read moreRead less
Analysis Of Antigen Receptor Sharing By T And B Lymphocytes
Funder
National Health and Medical Research Council
Funding Amount
$540,356.00
Summary
To survive an infection the immune system must rapidly expand the number of immune cells that have pathogen-specific receptors that recognise, and therefore specifically combat, the infection. This normally occurs through proliferation of the immune cells. We have found that in addition to proliferation, the number of cells with these receptors can be increased by a process of receptor transfer between cells. This grant aims to further advance our understanding of this novel phenomenon.
Characteristics Of Intervention Research That Progresses To 'real-world' Implementation”
Funder
National Health and Medical Research Council
Funding Amount
$555,851.00
Summary
Governments, health agencies and the public are interested in knowing whether publicly funded research “makes a difference” . This project examines 8 years of NHMRC funded research on clinical and community based interventions to change health to better understand understand factors that best promote effective research being later implemented to benefit the community. It will assist planning to facilitate more useful research being funded.
The Value Of Providing Health Interventions For Heroin Use: A Cost Benefit Analysis
Funder
National Health and Medical Research Council
Funding Amount
$599,585.00
Summary
Heroin use and associated harms can be reduced through effective treatment. Past research has shown that treatment for heroin dependence can be relatively cost-effective, but not whether heroin treatment overall is a good investment. This unique study will estimate the net social benefit of heroin treatment, taking into account health, crime and family consequences. The results will help Australia respond better to this devastating health problem.
Evaluating Population-wide Efforts To Reduce Tobacco Use: Continuation Of The ITC-Four Country Cohort In Australia
Funder
National Health and Medical Research Council
Funding Amount
$1,368,936.00
Summary
This study is part of a large international collaboration to study whether policies directed at whole communities work as planned. We survey around 2000 smokers from each of 4 countries every year. We compare reactions of smokers in a country with a policy to those in a country without such a policy or with a different policy. We do this by following through the likely chain of effects to smoking cessation. In this way we can provide advice to governments not only on whether their policies work ....This study is part of a large international collaboration to study whether policies directed at whole communities work as planned. We survey around 2000 smokers from each of 4 countries every year. We compare reactions of smokers in a country with a policy to those in a country without such a policy or with a different policy. We do this by following through the likely chain of effects to smoking cessation. In this way we can provide advice to governments not only on whether their policies work as intended, but how to improve them.Read moreRead less
Explaining Social Preferences For Priority Setting In The Health Sector
Funder
National Health and Medical Research Council
Funding Amount
$235,218.00
Summary
This project looks at whether the views of the public regarding the allocation of society's limited health care resources are well-informed and carefully considered. A series of focus groups will be conducted where members of the public can think about the ethical issues involved, discuss them with others, and ask questions. This approach has the potential to improve the legitimacy of health policy decisions by contributing to a better understanding of the values of the public.
Evaluation Of Alcohol Management Plans (AMPs), Cape York, North Queensland
Funder
National Health and Medical Research Council
Funding Amount
$626,395.00
Summary
The study will describe long-term impacts on important health and social outcomes of restricting alcohol in Cape York, Queensland. It will assess the impacts and cost-effectiveness of the Queensland Government’s Alcohol Management Plans implemented from 2002-03. The researchers will use de-identified data on injury, violence, health and social indicators. The study will map whether AMP components were delivered as promised and the extent to which they were welcomed by Cape York communities.
First-Line Management Of Youth Depression: A Randomised Placebo-Controlled Trial Of Fluoxetine And Cognitive Behavioural Therapy
Funder
National Health and Medical Research Council
Funding Amount
$1,316,648.00
Summary
The study aims to establish how to best treat adolescents and young adults when they present to mental health clinics with moderate-to-severe depression. There is, at present, considerable uncertainty as to whether young people should be started on antidepressant treatment at the same time as psychotherapy, or whether psychotherapy alone be commenced first. The study aims to clarify this important issue by implementing a trial that compares both treatment approaches.
A Randomized Controlled Trial Of Effects Of Early Life Exposure To General Anaesthesia On Neurobehavioural Outcomes In Children With Cystic Fibrosis (CF)
Funder
National Health and Medical Research Council
Funding Amount
$587,240.00
Summary
Anaesthesia permits surgeries and other interventional procedures that benefit the health of children to be performed painlessly and non-traumatically. This study will provide critical information about whether the drugs used commonly for general anaesthesia represents a risk to very young children in terms of their neurobehavioural development.
The Effects Of Different Alcohol Pricing Policies On Alcohol Consumption, Health, Social And Economic Outcomes, And Health Inequality In Australia
Funder
National Health and Medical Research Council
Funding Amount
$276,738.00
Summary
This project will examine the effects, effectiveness and cost-benefits of alcohol pricing policy initiatives in reducing risky drinking, health and social harms and health inequalities among priority populations in Australia. This project will provide key research evidence to cut through current policy debates and will point towards the most effective potential options for alcohol tax reform.