Radiotherapy Treatment For Prostate Cancer - A Change In Practice Based On Direct Evidence For Targeting And Toxicity Effects Using Real Outcomes Data
Funder
National Health and Medical Research Council
Funding Amount
$555,129.00
Summary
Radiotherapy for prostate cancer treatment will be more effective when we have better knowledge of what patient anatomy needs to be targeted, and what needs to be avoided. This project will combine data collected during a large Australasian prostate cancer radiotherapy trial, ‘RADAR’, with data collected using new patient imaging methods to determine how patient anatomy impacts on the effectiveness of their treatment and the side-effects they experience.
Heparin-induced Thrombocytopenia And Thrombosis: Better Understanding Of Pathogenesis And Improving Diagnosis And Treatment
Funder
National Health and Medical Research Council
Funding Amount
$653,137.00
Summary
Heparin, a widely used drug, can cause an adverse effect which results in a fall of the platelet count and the development of serious thrombosis. This drug complication is mediated by an immune mechanism. This proposal aims to provide a better understanding of the disease mechanism. It also aims to develop a new test that will improve the diagnosis, and to produce a novel drug that will effectively suppress the immune reaction and improve the treatment.
Development Of A New High Throughput Screen For Drug Binding To HERG K+ Channels
Funder
National Health and Medical Research Council
Funding Amount
$351,320.00
Summary
Inadvertent drug block of hERG, a potassium channel in the heart, can cause cardiac arrhythmias and sudden cardiac death. Screening for hERG toxicity has become a major hurdle for development of new drugs. We will use a mutant hERG protein that has enhanced drug binding to develop a high throughput test for hERG toxicity. Identification of dangerous drugs early in the drug discovery process will save the pharmaceutical industry millions of dollars in the costs of brining new drugs to market.
Drug-induced Immune Thrombocytopenia: Understanding The Disease Mechanisms Is The Key To Better Treatment
Funder
National Health and Medical Research Council
Funding Amount
$509,550.00
Summary
Many very commonly used medications cause an allergic reaction in a small number of patients that receive them. The allergic reaction results in platelets being destroyed and puts the patients at risk of bleeding. The patient recovers slowly if the drug is stopped but there is no other treatment and no way to reverse the effect quickly if the patient starts to bleed. This project will try to understand the mechanism of the condition and test a potential treatment.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE150100081
Funder
Australian Research Council
Funding Amount
$220,000.00
Summary
DomeLab: an ultra-high resolution experimental fulldome. DomeLab - an ultra-high resolution experimental fulldome: This project will establish the first ultra-high resolution (4000 x 4000 pixels) experimental fulldome in Australia (DomeLab). This fulldome facility will provide a powerful immersive dome-based video projection environment. Partners will work collaboratively across three themes: interactive media, future museology and experimental humanities. Through the national research services ....DomeLab: an ultra-high resolution experimental fulldome. DomeLab - an ultra-high resolution experimental fulldome: This project will establish the first ultra-high resolution (4000 x 4000 pixels) experimental fulldome in Australia (DomeLab). This fulldome facility will provide a powerful immersive dome-based video projection environment. Partners will work collaboratively across three themes: interactive media, future museology and experimental humanities. Through the national research services AARNet and Intersect's research data storage infrastructure, DomeLab will extend pioneering research in aesthetic frameworks and frontier technologies to benefit artistic, cultural, museological and humanities researchers. DomeLab is designed as a touring system and will be installed throughout the country at leading institutions. Read moreRead less
When science meets art: an environmental portrait of the Shoalhaven River Valley. This project will involve a collaboration between art and science to create an environmental and cultural portrait of the Shoalhaven River Valley. Environmental readings of river and land quality will be converted into a visual and audio display for both on-site and off-site visitors.
Transforming visualisation in museums: deep mapping for narrative coherence. This project aims to evaluate the use of interactive virtual environments in the museum context. This project plans to create the world's first narrative-driven multi-user ‘deep mapping data browser’ to produce a visualisation of cultural heritage. The project intends to conduct user evaluation across three museum sites — in Australia, Hong Kong and China. Intended outcomes are innovation in museum interpretation and tr ....Transforming visualisation in museums: deep mapping for narrative coherence. This project aims to evaluate the use of interactive virtual environments in the museum context. This project plans to create the world's first narrative-driven multi-user ‘deep mapping data browser’ to produce a visualisation of cultural heritage. The project intends to conduct user evaluation across three museum sites — in Australia, Hong Kong and China. Intended outcomes are innovation in museum interpretation and transformation of public access to digital archives.Read moreRead less
Narrative reformulation of museological data: the coherent representation of information by users in interactive systems. The proposed research seeks to provide Australia with a long-term opportunity to enhance its involvement in the billion-dollar creative economy by building the world’s first immersive 360-degree interactive data browser. Research into such systems benefits society by providing a cutting-edge development in digital technology and information access that enables a creative inno ....Narrative reformulation of museological data: the coherent representation of information by users in interactive systems. The proposed research seeks to provide Australia with a long-term opportunity to enhance its involvement in the billion-dollar creative economy by building the world’s first immersive 360-degree interactive data browser. Research into such systems benefits society by providing a cutting-edge development in digital technology and information access that enables a creative innovation culture. Through applied research into the narrative forms that underpin museological archives, this study will ensure that Australia remains at the forefront of the growing world-wide research into interactive technology thereby assisting the global digital media industry to tackle emergent challenges. Read moreRead less
A Randomised Open-label Study Comparing The Safety And Efficacy Of Two Alternative Treatment Options In The Management Of HIV-1 Infected Participants Who Have Virologically Failed A Standard First-line Combination ART Regimen
Funder
National Health and Medical Research Council
Funding Amount
$457,676.00
Summary
For the past decade there has been an unprecedented international effort to provide access to care for all HIV-infected people as a basic human right. Most of these people are treated with a simple combination of drugs that are well proven to control HIV. However, what to do when this first drug combination stops working is unknown. This study aims to fill that knowledge gap so that patients failing the first drug combination can be offered a second combination with a maximal chance of success.
A Phase III Trial Comparing Adjuvant Versus Salvage Radiotherapy For High Risk Patients Post Radical Prostatectomy
Funder
National Health and Medical Research Council
Funding Amount
$819,138.00
Summary
About half of all patients Treated with an operation to remove their prostate cancer have a high chance of the cancer coming back. Giving immediate radiotherapy to all patients will improve cure rates but does not benefit all men and can cause significant side effects. This study explores whether it is safe to wait and only give radiotherapy when there is a rising PSA after surgery indicating active cancer. A total of 470 men from Australasia will enter this study comparing the two approaches.