The Interplay Between Viperin, Peroxisomes And The Cellular Innate Antiviral Response
Funder
National Health and Medical Research Council
Funding Amount
$556,127.00
Summary
Infection with a virus initiates a cellular antiviral response that attempts to limit viral replication, however how this response is regulated is not well understood. In this proposal we will investigate a cellular protein (viperin) that can regulate this process by interaction with peroxisomes to amplify the antiviral response. This work will provide possible targets for therapeutic manipulation of the innate immune response that will be applicable to a wide range of viral infections.
Defining The Interaction Of HIV With The Interferon System In Initial Mucosal Infection
Funder
National Health and Medical Research Council
Funding Amount
$867,716.00
Summary
Very early after virus exposure, immune cells secrete interferons that help limit the spread of viruses within the body. We will investigate the complex interplay between HIV and the interferon system, especially how HIV inhibits the early induction of interferon to aid its spread and then how the body later restores the interferon response. We will also examine how HIV manipulates the interferon system in order to persistent latent reservoirs within tissues.
Cell Type Specific Biologic Responses To HIV Infection
Funder
National Health and Medical Research Council
Funding Amount
$636,242.00
Summary
The way in which HIV alters the internal environment of its target cells to facilitate its growth will be examined. These changes enhance its ability to gain a toehold in the human body after entering the genital tract and its persistence for life in the brain and elsewhere in the body.
Global Lithospheric Architecture Mapping II. The continents have been rifted, or broken up, and collided, or re-assembled, along major zones of weakness many times throughout Earth's history. Boundaries between such continental domains focus large-scale movements of fluids that can produce giant ore deposits. This study will provide new perspectives on the localisation of world-class economic deposits, the Earth resources on which society depends. Innovations in imaging the deep Earth beneath co ....Global Lithospheric Architecture Mapping II. The continents have been rifted, or broken up, and collided, or re-assembled, along major zones of weakness many times throughout Earth's history. Boundaries between such continental domains focus large-scale movements of fluids that can produce giant ore deposits. This study will provide new perspectives on the localisation of world-class economic deposits, the Earth resources on which society depends. Innovations in imaging the deep Earth beneath continents, and in numerical modelling, will maintain our high international profile in research relevant to National Priority 1.6 (Developing Deep Earth Resources). Unique 3D geological maps of regions down to 250km will make the composition of deep Earth regions newly accessible to geoscientists and all potential endusers.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0989986
Funder
Australian Research Council
Funding Amount
$230,000.00
Summary
Hybrid Fourier Transform Dispersive Raman Micro-Spectrometer. This facility will be used in a wide range of existing and new research projects in government priority areas such as the development of new materials, frontier technologies for building and transforming existing industries, better understanding of diversity and functioning in mycorrhizal and other fungi in forest soils and plant roots and developing new characterisation methods for forensic investigations. The proposed equipment aims ....Hybrid Fourier Transform Dispersive Raman Micro-Spectrometer. This facility will be used in a wide range of existing and new research projects in government priority areas such as the development of new materials, frontier technologies for building and transforming existing industries, better understanding of diversity and functioning in mycorrhizal and other fungi in forest soils and plant roots and developing new characterisation methods for forensic investigations. The proposed equipment aims to provide outstanding opportunities for the training of research students, expanding research in the fields of materials, minerals, geological, environmental and forensic science enabling to maintain Australia's lead and competitiveness in cutting edge research and technology. Read moreRead less
A revolution in Earth History: Life and Environment in the Neoarchaean (2.5-2.8 Ga). This research will keep Australian scientists in the forefront of studies of early life on Earth. At a time when there is a great deal of interest in this topic because of the search for similar life elsewhere in the Solar System, this work will take a prominant place in international research. It will attract leading researchers from elsewhere, with consequent intellectual benefits, and will inspire students t ....A revolution in Earth History: Life and Environment in the Neoarchaean (2.5-2.8 Ga). This research will keep Australian scientists in the forefront of studies of early life on Earth. At a time when there is a great deal of interest in this topic because of the search for similar life elsewhere in the Solar System, this work will take a prominant place in international research. It will attract leading researchers from elsewhere, with consequent intellectual benefits, and will inspire students to careers in science.Read moreRead less
A Mathematical Approach to Flexible Management of Open Pit Mines with Uncertain Geology and Unpredictable Demand. This project will create new mathematical algorithms to flexibly manage open pit mining projects. The development of strategic plans for mining operations is a highly complex task, based on incomplete geological information and uncertain future commodity demand. The smart mathematics we create will allow Australia to capitalise on upturns in international demand, while limiting unavo ....A Mathematical Approach to Flexible Management of Open Pit Mines with Uncertain Geology and Unpredictable Demand. This project will create new mathematical algorithms to flexibly manage open pit mining projects. The development of strategic plans for mining operations is a highly complex task, based on incomplete geological information and uncertain future commodity demand. The smart mathematics we create will allow Australia to capitalise on upturns in international demand, while limiting unavoidable negative outcomes, by flexibly adjusting the mining operation to prevailing geological and economic conditions. Australia's mineral exports are worth over $50b annually to the Australian economy. Our techniques will better manage Australia's mining projects and capture new, emerging markets, significantly impacting on Australia's balance of trade.Read moreRead less
Trace element analysis of diamond: new applications to diamond fingerprinting and genesis. The project will provide new insights into the processes by which diamond crystallises in the Earth's mantle. A better understanding of these processes can lead to improved models and techniques for diamond exploration, enhancing the prospect of finding new deposits in Australia and abroad. The project will test the potential of trace-element microanalysis to fingerprint diamonds by source. If successful ....Trace element analysis of diamond: new applications to diamond fingerprinting and genesis. The project will provide new insights into the processes by which diamond crystallises in the Earth's mantle. A better understanding of these processes can lead to improved models and techniques for diamond exploration, enhancing the prospect of finding new deposits in Australia and abroad. The project will test the potential of trace-element microanalysis to fingerprint diamonds by source. If successful, this technology will provide economic benefits by reducing theft and illegal mining, which represent significant losses to legitimate companies. Application of this Australian development could reduce the circulation of "conflict diamonds", which would have real social benefits worldwide, especially in some developing countries.Read moreRead less
Carbothermal synthesis of titanium carbide. The project's ultimate aim is to develop a comprehensive understanding of carbothermal reduction of titania and ilmenite for titanium carbide production. The projects findings will be of importance to improving the efficiency of carbothermal reduction processes, which are major technologies in ferrous metallurgy, and to the development of titanium industry in Australia.
Australia is the world largest producer of rutile and ilmenite, which are mainly s ....Carbothermal synthesis of titanium carbide. The project's ultimate aim is to develop a comprehensive understanding of carbothermal reduction of titania and ilmenite for titanium carbide production. The projects findings will be of importance to improving the efficiency of carbothermal reduction processes, which are major technologies in ferrous metallurgy, and to the development of titanium industry in Australia.
Australia is the world largest producer of rutile and ilmenite, which are mainly sold overseas and partly processed to titania pigment. Development of the cost-efficient technology for titanium carbide will stimulate a domestic production of this advanced material, what will add enormously to the value of titanium minerals.Read moreRead less
Utilisation of manganese sludge in production of manganese alloys. Australia possesses one of the world's best deposits of manganese ore, and has the potential to increase production of manganese alloys. This depends strongly on the competitiveness of Australian manganese industry. Deposition of manganese sludge, which is formed in ferroalloy furnaces, in fume dams in Bell Bay is costly, occupies valuable land, and causes an environmental concern. Utilisation of manganese sludge back into ferroa ....Utilisation of manganese sludge in production of manganese alloys. Australia possesses one of the world's best deposits of manganese ore, and has the potential to increase production of manganese alloys. This depends strongly on the competitiveness of Australian manganese industry. Deposition of manganese sludge, which is formed in ferroalloy furnaces, in fume dams in Bell Bay is costly, occupies valuable land, and causes an environmental concern. Utilisation of manganese sludge back into ferroalloy furnace will make operation of Tasmanian Electro Metallurgical Company more efficient, sustainable and will stimulate further development of manganese industry in Australia. Read moreRead less