Developing A New Glaucoma Surgery Using Precision Ablation Of The Trabecular Meshwork And Inner Wall Of Schlemm’s Canal
Funder
National Health and Medical Research Council
Funding Amount
$653,606.00
Summary
Glaucoma is a major sight threatening disease in our community, affecting an estimated 60 million people worldwide. This project investigates a new laser based method for reducing intraocular pressure, the major risk factor in glaucoma. The novel approach is to create a selectable number of drainage channels for excess fluid in the eye to drain away, thereby restoring normal intraocular pressure.
AGE-RELATED IMPAIRMENT OF AUTOREGULATION: A MODIFIABLE RISK FACTOR FOR GLAUCOMA
Funder
National Health and Medical Research Council
Funding Amount
$414,982.00
Summary
The prevalence and incidence of glaucoma increase dramatically with age. An impaired capacity to buffer against physiological pressure fluctuations in the eye with aging may play a key role in the development of glaucoma. This project will use non-invasive imaging to determine if impaired autoregulation increases the risk of developing glaucoma. It will determine if this age-related decline in autoregulation can be restored and in this way provide protection against glaucoma.
A pressure pulse may be felt at the wrist with every heart beat. New technology allows the analysis of this pulse and provides information that may help doctors make decisions about a patients risk related to blood pressure as well as the effect of drug treatment. The research aims to determine the clinical significance of pressure pulse analysis at rest and during light exercise. It is expected that the new technology will improve the way people with high blood pressure are treated.
Ultrasonic Blood Pressure Measurement On Implanted Biomedical Surfaces
Funder
National Health and Medical Research Council
Funding Amount
$170,250.00
Summary
The project would develop a prototype device reporting blood pressure on a biomedical implant surface. The device would extract data in real time from a standard ultrasound scanner that images the implant. The School of Mathematical Sciences at Monash University will be contracted to develop this ultrasound pressure sensor.
Renal AT2R Are A Therapeutic Target For The Treatment Of Hypertension In Women
Funder
National Health and Medical Research Council
Funding Amount
$605,939.00
Summary
Being female is associated with better renal function, resistenace to renal injury and hypertension, but it is not understood why. Our work demonstrates that women have more angiotensin type 2 receptors (AT2R) in the kidney then men. In men AT2R have been suggested to protect against hypertension and renal damage. We predict that the effects of AT2R stimulation will be greater in women and therefore the protective benefits greater.