Contributions Of Intrinsic Renal Cells To Inflammatory Renal Injury
Funder
National Health and Medical Research Council
Funding Amount
$66,433.00
Summary
These studies aim to improve our understanding of glomeruonephritis, the most common cause of kidney failure. They will study the interactions between circulating white blood cells (leukocytes) which originate from the bone marrow , and intrinsic kidney cells in the development of tis disease. Inflammation is the result of recruitment of bone marrow derived inflammatory cells and plasma proteins to a variety of stimuli. The subsequent injury represents the interaction between recruited cells and ....These studies aim to improve our understanding of glomeruonephritis, the most common cause of kidney failure. They will study the interactions between circulating white blood cells (leukocytes) which originate from the bone marrow , and intrinsic kidney cells in the development of tis disease. Inflammation is the result of recruitment of bone marrow derived inflammatory cells and plasma proteins to a variety of stimuli. The subsequent injury represents the interaction between recruited cells and local cells within the target organ. Glomerulonephritis is an important human disease where both bone marrow derived inflammatory and local cells have the potential to contribute to kidney injury by production of signalling molecules called cytokines. This study will determine the contribution of specific cytokines produced by intrinsic renal cells towards the development of inflammatory kidney injury in GN.Read moreRead less
Why Do People Keep Hurting Their Back: A Longitudinal Study Of Biological, Psychological And Social Predictors
Funder
National Health and Medical Research Council
Funding Amount
$739,946.00
Summary
We aim to identify why people continue to suffer episodes of back pain. If we can identify factors that predict the course of back pain we can target treatments to the right people to reduce the burden of this common condition. We will follow people for a year after an acute episode. We will measure novel issues like control of trunk muscles, inflammatory response, and how the nervous system deals with pain. We will also investigate how these factors interact with social and psychological issues
Mechanisms Of Serotonergic And Triptan Mediated Analgesia Within The Midbrain
Funder
National Health and Medical Research Council
Funding Amount
$546,937.00
Summary
Chronic pain requires multiple pharmacological interventions and these are often ineffective. These drugs include those which act on a diverse group of cell-surface proteins, called serotonin receptors. This project will use cellular and whole animal techniques to examine how these agents act within intrinsic pain and anxiety control systems within the brain in order to identify novel analgesic pharmacotherapies with enhanced efficacy and reduced side effects.
Software Defined Networking: Transforming Emergency Operations. The project aims to improve the effectiveness and efficiency of Australia's emergency operations, for example, bushfire and rescue missions, by providing robust and integrated communications systems for police and the emergency services. Emergency communications systems are currently fragmented by the different technologies, creating disconnected islands of information. The project aims to provide techniques that allow multiple wire ....Software Defined Networking: Transforming Emergency Operations. The project aims to improve the effectiveness and efficiency of Australia's emergency operations, for example, bushfire and rescue missions, by providing robust and integrated communications systems for police and the emergency services. Emergency communications systems are currently fragmented by the different technologies, creating disconnected islands of information. The project aims to provide techniques that allow multiple wireless technologies to communicate seamlessly using modern software-defined networking solutions.Read moreRead less
Real-time internet of thing algorithms with performance guarantees. This project aims to provide efficient, distributed resource allocation algorithms that can perform satisfactorily within time limits imposed by real-time systems. Real-time Internet of Things (IoT) devices will play a significant role in future transport technologies, such as autonomous vehicles and smart traffic management, and will place significant demands upon distributed computing systems to provide timely information upda ....Real-time internet of thing algorithms with performance guarantees. This project aims to provide efficient, distributed resource allocation algorithms that can perform satisfactorily within time limits imposed by real-time systems. Real-time Internet of Things (IoT) devices will play a significant role in future transport technologies, such as autonomous vehicles and smart traffic management, and will place significant demands upon distributed computing systems to provide timely information updates. The computing challenge is to provide reliable, accurate and timely information to IoT devices. The outcomes of this project will directly be beneficial to a variety of IoT applications in transportation, autonomous vehicles, and smart cities. The valuable engineering insights and novel algorithms will support industry, government, and practitioners for future real-time IoT design and deployments.Read moreRead less
Tools and models for measuring and predicting growth in internet addressing and routing complexity. We analyse patterns in the allocation and actual use of Internet Protocol version 4 (IPv4) addresses to predict the technical and market pressures for deployment of IPv6. The utilisation models will help evaluate the potential for emerging markets in scarce IPv4 address prefixes to increase costs to the end-users of Australia's future national broadband network.
Optical wireless frontier: Design challenges of multi gigabit wireless. This project aims to improve the coverage, mobile access, miniaturisation, bandwidth and networking of optical wireless. As connected machines become the primary consumers of the Internet, technologies for wirelessly connecting devices, processors, storage and display devices at very high speeds become necessary for mission critical services and applications. Gigabit wireless access needs to overcome shortages in the radio-f ....Optical wireless frontier: Design challenges of multi gigabit wireless. This project aims to improve the coverage, mobile access, miniaturisation, bandwidth and networking of optical wireless. As connected machines become the primary consumers of the Internet, technologies for wirelessly connecting devices, processors, storage and display devices at very high speeds become necessary for mission critical services and applications. Gigabit wireless access needs to overcome shortages in the radio-frequency spectrum and provide scalable bandwidth and wider coverage. Optical wireless transmission is a real alternative to current wireless systems because its connection speed of tens of gigabits/second means it can work efficiently with wired optical networking technologies. This project is expected to lead to optical wireless technology.Read moreRead less
Photonics Platform to Transform Mobile Fronthaul Infrastructure. Future wireless systems of mobile networks and defence platforms will need to offer high-speed, low-delay, reliable connectivity and high bandwidth. With the explosive growth of wireless systems, this creates significant challenges in fronthaul - the link connecting antennas with the signal processors and core network. This project aims to design and develop an innovative fronthaul for wireless systems based on a dynamically reconf ....Photonics Platform to Transform Mobile Fronthaul Infrastructure. Future wireless systems of mobile networks and defence platforms will need to offer high-speed, low-delay, reliable connectivity and high bandwidth. With the explosive growth of wireless systems, this creates significant challenges in fronthaul - the link connecting antennas with the signal processors and core network. This project aims to design and develop an innovative fronthaul for wireless systems based on a dynamically reconfigurable, software-defined photonic platform capable of meeting diverse requirements. The outcomes of this project will help build a scalable fronthaul solution to overcome fundamental challenges and realise cost-effective pathways for transforming how future wireless networks and defence platforms are realised.Read moreRead less
Large-scale highly dynamic wireless networks: architecture and communication strategies design. This project will develop novel techniques for the modelling, design and management of highly dynamic networks, with wireless vehicular networks for autonomous vehicles being a typical but not sole example. Social and economical benefits are expected in the areas of road traffic management and road safety, communication and environment protection.