Discovery Early Career Researcher Award - Grant ID: DE140101268
Funder
Australian Research Council
Funding Amount
$386,820.00
Summary
Stochastic mathematical modelling of the Wnt signalling pathway. The Wnt signalling pathway is pivotal in multicellular organisms, regulating cellular processes such as proliferation, apoptosis and migration. Faulty Wnt signalling is associated with degenerative diseases, developmental disorders and cancers and is therefore a potential target for therapeutic drugs. This project will perform a stochastic spatial simulation of the Wnt signalling pathway which will be matched to experimental data. ....Stochastic mathematical modelling of the Wnt signalling pathway. The Wnt signalling pathway is pivotal in multicellular organisms, regulating cellular processes such as proliferation, apoptosis and migration. Faulty Wnt signalling is associated with degenerative diseases, developmental disorders and cancers and is therefore a potential target for therapeutic drugs. This project will perform a stochastic spatial simulation of the Wnt signalling pathway which will be matched to experimental data. The model will be extended to integrate with the cell cycle. Increased proliferation in tumours has been linked to mutations in Wnt components. Using the extended model, the effect of Wnt-targeting therapeutic cancer drugs on cancer cell proliferation rates will be predicted and compared to experiments.Read moreRead less
Using Mathematics to Maximize the Value of Open-Pit Mines. Mineral resources are one of Australia's greatest assets. Their effective management will bring substantial long-term benefits to the Australian economy. Planning the exploitation of a mineral resource is a highly complex task. Current methods are approximate, and do not fully consider two critical issues: (1) ore mined at different times must be blended to achieve saleable product and (2) resource markets may not evolve as predicted ....Using Mathematics to Maximize the Value of Open-Pit Mines. Mineral resources are one of Australia's greatest assets. Their effective management will bring substantial long-term benefits to the Australian economy. Planning the exploitation of a mineral resource is a highly complex task. Current methods are approximate, and do not fully consider two critical issues: (1) ore mined at different times must be blended to achieve saleable product and (2) resource markets may not evolve as predicted. In this project we shall develop creative mathematical solutions to maximise the expected net present value of mines with far greater accuracy, taking into account blending and the uncertain nature of future demand.Read moreRead less