Establishing nanoscale design principles for non-viral genome engineering. This project aims to develop a bio-nanotechnology platform for non-viral genome engineering using dendronised polymers. The project will advance both fundamental and practical knowledge at the forefront of nanotechnology and cell biology, whilst providing training to the research community. Outcomes from the project will also provide significant benefits, such as positioning Australia at the forefront of genome engineerin ....Establishing nanoscale design principles for non-viral genome engineering. This project aims to develop a bio-nanotechnology platform for non-viral genome engineering using dendronised polymers. The project will advance both fundamental and practical knowledge at the forefront of nanotechnology and cell biology, whilst providing training to the research community. Outcomes from the project will also provide significant benefits, such as positioning Australia at the forefront of genome engineering.Read moreRead less
Ultra-fast alchemy: a new strategy to synthesise super-dense nanomaterials. We have recently created a new super-dense aluminium phase by ultrafast laser microexplosion. This project will search further for new super-dense material phases with drastically different and exotic properties, such as those inside planets and stars, and which have great potential as new nanomaterials for industrial applications.
Engineered plant receptors as orthogonal neuronal switches. This project aims to develop synthetic biology methods to study brain function by utilising engineered plant receptors. This project will expand our ability to manipulate nerve cell function with high specificity and without side effects in freely behaving animals. Plant receptors will be developed into molecular tools in an iterative process that improves key properties using rational protein design. Expected outcomes include innovativ ....Engineered plant receptors as orthogonal neuronal switches. This project aims to develop synthetic biology methods to study brain function by utilising engineered plant receptors. This project will expand our ability to manipulate nerve cell function with high specificity and without side effects in freely behaving animals. Plant receptors will be developed into molecular tools in an iterative process that improves key properties using rational protein design. Expected outcomes include innovative and broadly-applicable neuroscience methods and an understanding of receptors involved in plant growth and defense. Benefits of this project include an enhanced capacity to generate knowledge, multidisciplinary training opportunities and patentable synthetic biology technologies.Read moreRead less
Engineered ion channels for selective and switchable ion conduction. This project aims to develop an innovative bioinspired approach for fabricating angstrom-sized ion-channel membranes with specific ion selectivity, high ion conductivity and efficient gating function comparable to biological ion channels. Engineering of artificial channels with ion-channel-like shapes, ion selectivity filters and functional gates is expected to bring high-efficiency technologies to applications such as membrane ....Engineered ion channels for selective and switchable ion conduction. This project aims to develop an innovative bioinspired approach for fabricating angstrom-sized ion-channel membranes with specific ion selectivity, high ion conductivity and efficient gating function comparable to biological ion channels. Engineering of artificial channels with ion-channel-like shapes, ion selectivity filters and functional gates is expected to bring high-efficiency technologies to applications such as membrane separation and energy conversion. This project has potential to result in new knowledge of biomimetic design of artificial ion-channel membranes and directly benefit manufacturing industry for Australia.Read moreRead less
A quantum bus for large-scale diamond quantum computers. This project aims to experimentally demonstrate a device needed to bus quantum information between defect clusters in large scale quantum computers. Quantum computers could transcend limits of today’s ‘classical’ computers. Diamond is a proven platform for small-scale quantum computing and simple quantum algorithms have already been demonstrated using small clusters of diamond defects. To build a large-scale quantum computer that can reali ....A quantum bus for large-scale diamond quantum computers. This project aims to experimentally demonstrate a device needed to bus quantum information between defect clusters in large scale quantum computers. Quantum computers could transcend limits of today’s ‘classical’ computers. Diamond is a proven platform for small-scale quantum computing and simple quantum algorithms have already been demonstrated using small clusters of diamond defects. To build a large-scale quantum computer that can realise the potential of quantum computing, a device must be invented to bus quantum information between defect clusters. This project will experimentally demonstrate physical mechanisms that were theoretically identified for the operation of such a device. This is expected to make a quantum bus for large-scale diamond quantum computers possible.Read moreRead less
A multiplex microscope platform to define molecular events in fluid systems. This project aims to develop a novel microscopy platform that will enable the visualisation and quantification of molecular events occurring under fluid shear stress. The project will generate new knowledge in platelet biology that will allow characterisation and prediction of key molecular and morphological changes occurring across a blood thrombus under flowing conditions as found in the blood vessels. These new tools ....A multiplex microscope platform to define molecular events in fluid systems. This project aims to develop a novel microscopy platform that will enable the visualisation and quantification of molecular events occurring under fluid shear stress. The project will generate new knowledge in platelet biology that will allow characterisation and prediction of key molecular and morphological changes occurring across a blood thrombus under flowing conditions as found in the blood vessels. These new tools and the imaging platform will have applications for researchers wishing to visualise small and rapid molecular events in four dimensions (length, width, height and across time) under fluid shear stress, which is applicable across a range of industries. The project expects to deliver the next generation of intravital microscopes that can visualise and quantify events in a challenging flow environment.Read moreRead less
Mechanical control of defect spins in diamond and its applications in quantum technology. This project will demonstrate the mechanical control of optically addressable defect spins in diamond in order to rapidly exploit innovative approaches to quantum technologies, including high sensitivity metrology and information processing. This will be achieved by capitalising on the proven quantum applications of the nitrogen-vacancy defect centre in diamond and the performance of both fundamental inquir ....Mechanical control of defect spins in diamond and its applications in quantum technology. This project will demonstrate the mechanical control of optically addressable defect spins in diamond in order to rapidly exploit innovative approaches to quantum technologies, including high sensitivity metrology and information processing. This will be achieved by capitalising on the proven quantum applications of the nitrogen-vacancy defect centre in diamond and the performance of both fundamental inquiry into the effects of mechanical stress on this centre and the design, fabrication and operation of simple nano-mechanical devices. Read moreRead less
Unlocking exceptional properties through pressure-induced phase transitions. The aim of this project is to produce novel hybrid boron nitride materials by utilizing advanced green techniques of mechanochemistry and high-pressure methods to achieve a phase transition from hexagonal to wurtzite structure. The development of these materials is critical in tackling contemporary environmental and technological issues, particularly those linked to cooling systems in electronic devices and batteries. T ....Unlocking exceptional properties through pressure-induced phase transitions. The aim of this project is to produce novel hybrid boron nitride materials by utilizing advanced green techniques of mechanochemistry and high-pressure methods to achieve a phase transition from hexagonal to wurtzite structure. The development of these materials is critical in tackling contemporary environmental and technological issues, particularly those linked to cooling systems in electronic devices and batteries. The outcome of this study will be new nanomaterials with exceptional mechanical, thermal, and electronic properties, as well as new insights into mechanical-force induced green chemistry and an environmentally friendly synthesis process, and help with heat management, energy preservation, and advanced manufacturing.Read moreRead less
Generating multi-component scaffolding to influence the differentiation of embryonic stem cells. Nervous system diseases are debilitating and will develop in over 50 per cent of people at some time in their life. This project will develop strategies so that stem cells can be utilised to encourage brain repair for the treatment of Parkinson's disease. The technology developed will also be of benefit for the treatment of other nervous system disorders.
Modelling human brain development with stem cells and biomaterials. With limited resources to directly study and advance our understanding of human neural development, this
proposal will establish models of 4 key stages. Employing innovative, interdisciplinary approaches, biomaterials will be fabricated to provide structural and chemical support for human stem cells during: (i) neural induction, (ii) specification into neuronal progenitor subpopulations, (iii) neuronal maturation and integration ....Modelling human brain development with stem cells and biomaterials. With limited resources to directly study and advance our understanding of human neural development, this
proposal will establish models of 4 key stages. Employing innovative, interdisciplinary approaches, biomaterials will be fabricated to provide structural and chemical support for human stem cells during: (i) neural induction, (ii) specification into neuronal progenitor subpopulations, (iii) neuronal maturation and integration into complex neural networks as well as, (iv) the organisation of neurons into larger 3-dimensional brain structures, namely folding of the human cortex. Further, biomaterials developed here have commercialisation potential, targeted at standardizing the culturing of human stem cells to defined neural populations.
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