Establishing Design Principles Of Polymers For Intracellular Delivery . Engineered polymers have played a central role in the field of bionanotechnology by enabling targeted nanoscale cell interactions. Progress in the field of intracellular delivery is currently affected by a major bottleneck due to the absence of effective polymers that is applicable across the range of bimolecular cargoes. In essence depending on the type of cargo: DNA, RNA or protien, the polymer needs programmability. The l ....Establishing Design Principles Of Polymers For Intracellular Delivery . Engineered polymers have played a central role in the field of bionanotechnology by enabling targeted nanoscale cell interactions. Progress in the field of intracellular delivery is currently affected by a major bottleneck due to the absence of effective polymers that is applicable across the range of bimolecular cargoes. In essence depending on the type of cargo: DNA, RNA or protien, the polymer needs programmability. The limited tunability of traditional polymers agents makes them unsuitable for this particular application. The multidisciplinary project addresses this significant problem by engineering novel sequences of defined polymer based nanoscale agents to achieve efficient delivery in cells.Read moreRead less
Understanding the properties of layered nanostructures using in-situ TEM. This project aims to support the practical applications of layered nanostructure-based devices and systems. The development of layered chalcogenide nanostructures is a global research focus due to their potential applications in the energy sector. However, their structure–property link is unclear due to the lack of direct correlation between their structure and properties. This project aims to establish the intrinsic struc ....Understanding the properties of layered nanostructures using in-situ TEM. This project aims to support the practical applications of layered nanostructure-based devices and systems. The development of layered chalcogenide nanostructures is a global research focus due to their potential applications in the energy sector. However, their structure–property link is unclear due to the lack of direct correlation between their structure and properties. This project aims to establish the intrinsic structure–property link by closely correlating the structure (and structural variations) and properties (and varied properties) simultaneously determined from individual nanostructures inside a transmission electron microscope. Expected project outcomes may advance the knowledge base, and provide guidelines for the development of nanostructure-based devices for their high-performance applications, especially in the energy sector.Read moreRead less
Bioengineering self-assembly of innovative core-shell nanomaterials . This project aims to generate new knowledge in nanoscale bioengineering. It expects to develop a disruptive platform technology for design and manufacture of advanced nanomaterials to provide solutions for unmet needs in industry. It will explore an innovative bioengineering concept that merges biopolymer synthesis with virus-like particle self-assembly to produce innovative tunable core-shell nanomaterials. Expected outcomes ....Bioengineering self-assembly of innovative core-shell nanomaterials . This project aims to generate new knowledge in nanoscale bioengineering. It expects to develop a disruptive platform technology for design and manufacture of advanced nanomaterials to provide solutions for unmet needs in industry. It will explore an innovative bioengineering concept that merges biopolymer synthesis with virus-like particle self-assembly to produce innovative tunable core-shell nanomaterials. Expected outcomes are the development of advanced techniques for design and manufacture of innovate nanomaterials with enhanced stability and performance. This innovative platform technology for precision engineering of high-performance nanomaterials should provide significant benefits for biotechnological and agricultural industries.Read moreRead less
Protein structure prediction by deep long-range learning. This project aims to address the challenging problem of protein structure prediction by developing deep long-range learning methods. The project expects to advance protein structure prediction by capturing the long-range interactions through whole sequence learning, rather than short window-based learning. Expected outcomes include next-generation machine-learning techniques for predicting one, two and three-dimensional protein structures ....Protein structure prediction by deep long-range learning. This project aims to address the challenging problem of protein structure prediction by developing deep long-range learning methods. The project expects to advance protein structure prediction by capturing the long-range interactions through whole sequence learning, rather than short window-based learning. Expected outcomes include next-generation machine-learning techniques for predicting one, two and three-dimensional protein structures from their sequences. The expected outcomes should provide significant benefits by computationally determining protein structures beyond homologous sequences, and enabling structure-based drug discovery to disease-causing protein targets previously inaccessible to biotech and pharmaceutical companies.Read moreRead less
Capturing full-spectrum of solar energy using TiO2 ordered suprastructures. The project aims to develop a titanium dioxide (TiO2) semiconductor that can use full-spectrum solar energy. Solar-driven photocatalytic processes have important applications in water decontamination and energy production. Their effectiveness is dictated by the semiconductor’s absorbance and conversion of photoenergy to chemical energy. Being inexpensive, chemically and mechanically robust, TiO2 is the most promising mat ....Capturing full-spectrum of solar energy using TiO2 ordered suprastructures. The project aims to develop a titanium dioxide (TiO2) semiconductor that can use full-spectrum solar energy. Solar-driven photocatalytic processes have important applications in water decontamination and energy production. Their effectiveness is dictated by the semiconductor’s absorbance and conversion of photoenergy to chemical energy. Being inexpensive, chemically and mechanically robust, TiO2 is the most promising material for the semiconductor. However, unmodified TiO2 only absorbs ultraviolet light (5 per cent of solar energy). With current progress made in visible absorbance, this project aims to significantly improve TiO2’s absorbance in near infrared by doping with upconversion lanthanides and rendering colloidal crystal suprastructures that can trap light.Read moreRead less
Stretchable Organic Transistors for Wearable Electronics and Robotics. The project aims to address the challenges of fabricating stretchable organic transistors for applications in wearable electronics and robotics through the development of new semiconducting polymers with stretchability and integrating them into novel, stretchable organic transistor configurations. The project will take a molecular engineering approach to the complex needs of this challenge by combining appropriate chemical f ....Stretchable Organic Transistors for Wearable Electronics and Robotics. The project aims to address the challenges of fabricating stretchable organic transistors for applications in wearable electronics and robotics through the development of new semiconducting polymers with stretchability and integrating them into novel, stretchable organic transistor configurations. The project will take a molecular engineering approach to the complex needs of this challenge by combining appropriate chemical functionality which provides high charge carrier mobility with judiciously placed flexible spacers and side chains to provide mechanical dexterity. These novel polymers will be integrated into transistor structures and their fabricated arrays deposited on stretchable substrates will be used for a real world applications.Read moreRead less
Bespoke nanomaterials for understanding nano-bio interactions under flow. This project aims to develop innovative scalable synthesis techniques to produce polymeric nanomaterials with controlled properties and characterise interactions between nanomaterials and cells under flow conditions. This project expects to generate new knowledge in priority research areas of nanotechnology, polymer chemistry and immunology. The outcome of this project is an original scalable and environmentally friendly t ....Bespoke nanomaterials for understanding nano-bio interactions under flow. This project aims to develop innovative scalable synthesis techniques to produce polymeric nanomaterials with controlled properties and characterise interactions between nanomaterials and cells under flow conditions. This project expects to generate new knowledge in priority research areas of nanotechnology, polymer chemistry and immunology. The outcome of this project is an original scalable and environmentally friendly technology, new knowledge of cell-nanomaterial interactions and new design principles for nanoparticles with potential future applications in drug delivery, immunology and nanomedicine. This project should provide significant benefits to polymer, nanomaterial and pharmaceutical research and industry in Australia.Read moreRead less
Engineering floating liquid marbles for three-dimensional cell cultures. This project aims to understand the physics of three-dimensional cell cultures in a liquid marble floating on a liquid free surface. New methodology developed can produce these cell cultures without using matrices or scaffolds and with run-times well beyond existing technologies. This methodology closely mimics a normal in-vivo environment and produces spheroids needed in cell transplantation therapies. This project will re ....Engineering floating liquid marbles for three-dimensional cell cultures. This project aims to understand the physics of three-dimensional cell cultures in a liquid marble floating on a liquid free surface. New methodology developed can produce these cell cultures without using matrices or scaffolds and with run-times well beyond existing technologies. This methodology closely mimics a normal in-vivo environment and produces spheroids needed in cell transplantation therapies. This project will resolve uncertainties in the underlying phenomena. The expected outcome should support future high quality cell cultures suitable for transplantation therapies.Read moreRead less
Nano optoelectronic coupling: towards an ultrasensitive sensing technology. This project aims to elucidate ultrasensitive mechanical and thermal sensing effects that are tens of thousands of times better than conventional sensing technologies. This is achieved through controlling interactions between photons and electrons at the interface of two semiconductors. Outcomes of this project include scientific breakthroughs that are expected to revolutionise and disrupt the established sensing technol ....Nano optoelectronic coupling: towards an ultrasensitive sensing technology. This project aims to elucidate ultrasensitive mechanical and thermal sensing effects that are tens of thousands of times better than conventional sensing technologies. This is achieved through controlling interactions between photons and electrons at the interface of two semiconductors. Outcomes of this project include scientific breakthroughs that are expected to revolutionise and disrupt the established sensing technologies. Microscopic low power mechanical and thermal sensors with ultra-high sensitivity have great value to enhance safety, security, and productivity of industry and society. The project is expected to generate new knowledge and place Australia as the world leader in physical sensing and create a new industry.Read moreRead less
Advancing the visualisation and quantification of nephrons with MRI. . This project aims to characterise key components of nephrons, the glomeruli and tubules, using magnetic resonance imaging without contrast agents, in combination with Deep Learning and super-resolution techniques. Nephrons, the basic functional unit of the kidney, are critical to the maintenance of the body’s homeostasis. Their number and architecture are critical determinants of kidney function. The expected outcomes are inn ....Advancing the visualisation and quantification of nephrons with MRI. . This project aims to characterise key components of nephrons, the glomeruli and tubules, using magnetic resonance imaging without contrast agents, in combination with Deep Learning and super-resolution techniques. Nephrons, the basic functional unit of the kidney, are critical to the maintenance of the body’s homeostasis. Their number and architecture are critical determinants of kidney function. The expected outcomes are innovative semi-automated nephron visualisation and quantitation tools that enable efficient renal phenotyping. Techniques tailored to widely accessible preclinical research scanners are expected to accelerate research into genetic and environmental factors affecting kidney microstructure in embryonic and post-natal life.Read moreRead less