A Randomised Placebo-controlled Trial Of Antibiotics To Prevent Urinary Tract Infection In Children
Funder
National Health and Medical Research Council
Funding Amount
$735,000.00
Summary
This study is needed to determine whether a common clinical practice long-term antibiotic treatment for children following urinary tract infection (UTI) - is safe and effective in preventing further UTI and if so, whether all appropriate children are being treated. UTI will affect about 10% of Australian children by high school age (88,000 children per year). Because UTI may damage the kidneys, the management priority for children with UTI has been prevention of further infection. Currently this ....This study is needed to determine whether a common clinical practice long-term antibiotic treatment for children following urinary tract infection (UTI) - is safe and effective in preventing further UTI and if so, whether all appropriate children are being treated. UTI will affect about 10% of Australian children by high school age (88,000 children per year). Because UTI may damage the kidneys, the management priority for children with UTI has been prevention of further infection. Currently this means the identification of children thought to be most at risk of recurrent UTI by renal tract imaging. Those found to have reflux of urine from the bladder to the kidney (present in about 30% of those with UTI) are then placed on antibiotics fro 2-5 years. Unfortunately there has never been a properly designed trial to test whether antibiotics do really prevent UTI and if so, whether children with reflux are the appropriate and only group requiring treatment. Long term antibiotics may in fact do more harm than good because of side effects like skin, bowel and blood problems and because resistant bacteria may develop. The design of this study involves the random allocation of placebo or antibiotic (cotrimoxazole, the usual antibiotic given in this case) to about 800 children after their first symptomatic UTI. These children are treated and followed for one year to determine the rate of futher UTI in both groups. Any difference in outcome between the two groups of children will be because of the antibiotic treatment. This study may prove long-term antibiotics are ineffective and therefore should not be routinely used. In this case investigation of children to detect vesicoureteric reflux would serve little purpose and should be abandoned. Alternatively antibiotic treatment may be shown as effective treatment for preventing further UTI and in this case the study will clearly identify those children who will benefit.Read moreRead less
Special Research Initiatives - Grant ID: SR120300015
Funder
Australian Research Council
Funding Amount
$16,000,000.00
Summary
The Science of Learning Research Centre. In this innovative new Centre, researchers in education, neuroscience and cognitive psychology will work together with teachers to understand the learning process. This collaboration will establish new criteria to assess the impact of different types of learning and strategies to inform teaching practices of benefit to all Australians.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE200100117
Funder
Australian Research Council
Funding Amount
$1,275,000.00
Summary
A platform consortium for integrated 'systems-omics' research. The proposal aims to establish a multi-institutional integrated ‘systems-omics’ platform across two of Victoria’s leading research universities, and associated research institutes. The platform will consist of two cutting edge ultra-high resolution mass spectrometers (i) a Thermo Scientific Orbitrap Fusion LUMOS for rapid and comprehensive metabolomic profiling and detailed structural characterization, located at La Trobe University ....A platform consortium for integrated 'systems-omics' research. The proposal aims to establish a multi-institutional integrated ‘systems-omics’ platform across two of Victoria’s leading research universities, and associated research institutes. The platform will consist of two cutting edge ultra-high resolution mass spectrometers (i) a Thermo Scientific Orbitrap Fusion LUMOS for rapid and comprehensive metabolomic profiling and detailed structural characterization, located at La Trobe University, and (ii) a Thermo Scientific Orbitrap Q Exactive HFX for high-throughput, deep and reproducible quantitative proteome analysis, located at the University of Melbourne.This platform will address applications across the agri-biosciences, medicinal agriculture and fundamental biomedical sciences sectors.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE160100015
Funder
Australian Research Council
Funding Amount
$500,000.00
Summary
An Ultra High Resolution Mass Spectrometry Facility for Lipidomics Research. An ultra-high-resolution mass spectrometry facility for lipidomics research:
This proposal aims to establish an ultra-high-resolution, accurate mass spectrometry facility in Australia for comprehensive lipidomics research. The platform would consist of a Thermo Scientific Orbitrap Fusion mass spectrometer interfaced with ultra-high-pressure high-performance liquid chromatography. This proposal will address a major need ....An Ultra High Resolution Mass Spectrometry Facility for Lipidomics Research. An ultra-high-resolution mass spectrometry facility for lipidomics research:
This proposal aims to establish an ultra-high-resolution, accurate mass spectrometry facility in Australia for comprehensive lipidomics research. The platform would consist of a Thermo Scientific Orbitrap Fusion mass spectrometer interfaced with ultra-high-pressure high-performance liquid chromatography. This proposal will address a major need for advanced mass spectrometry-based lipid analysis capabilities across mammalian, plant, parasite, and microalgae research disciplines, as well as enabling fundamental studies of lipid separation, chemistry and reactivity. The instrumentation would be applicable to a diverse range of projects including studies of the role of lipid metabolism in mammalian biochemistry and cell biology, plant biology and parasitology, and micro algae biofuel production.Read moreRead less
The demographic consequences of migration to, from and within Australia. The long-term demographic consequences of migration to, from and within Australia, and the dynamic pathways that produced them, will be studied. This will involve the identification of the specific contributions made by international and internal migration to the age and sex population compositions of nine birthplace-specific populations from 1981 to 2011. To do this, publically available data will be collected and augmente ....The demographic consequences of migration to, from and within Australia. The long-term demographic consequences of migration to, from and within Australia, and the dynamic pathways that produced them, will be studied. This will involve the identification of the specific contributions made by international and internal migration to the age and sex population compositions of nine birthplace-specific populations from 1981 to 2011. To do this, publically available data will be collected and augmented with statistical methods to provide a complete, consistent account of population change for around 60 subnational areas. As migration and population change underpins many aspects of societal change in Australia, this research aims to provide an invaluable resource to other scientists and policy makers.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE150100181
Funder
Australian Research Council
Funding Amount
$183,413.00
Summary
Fieldwork or remote sensing? The blurred line of unmanned airborne systems. Fieldwork or remote sensing? The blurred line of unmanned airborne systems: The aim of the project is to develop a state-of-the-art Unmanned Airborne System (UAS) capability in support of field data acquisition. The system will provide highly detailed calibrated imagery of difficult or inaccessible survey sites and bridge the scale gap between in situ observations and imagery acquired by higher altitude airborne or satel ....Fieldwork or remote sensing? The blurred line of unmanned airborne systems. Fieldwork or remote sensing? The blurred line of unmanned airborne systems: The aim of the project is to develop a state-of-the-art Unmanned Airborne System (UAS) capability in support of field data acquisition. The system will provide highly detailed calibrated imagery of difficult or inaccessible survey sites and bridge the scale gap between in situ observations and imagery acquired by higher altitude airborne or satellite sensors. The UAS will have a diverse range of applications, including environmental monitoring, disaster management and recording sites of indigenous cultural significance. In addition, the system will be more flexible and cost effective than any other field or remote sensing tool.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE150100278
Funder
Australian Research Council
Funding Amount
$370,000.00
Summary
Automating the smart home: an investigation of automated cooling practices. Home automation technologies are expected to achieve reductions in household energy costs and consumption. However, there has been no systematic investigation of the ways in which they are being incorporated into everyday life. The project aims to address this critical gap in relation to home cooling. It will investigate how automated cooling technologies are being incorporated into household practices in Australia, and ....Automating the smart home: an investigation of automated cooling practices. Home automation technologies are expected to achieve reductions in household energy costs and consumption. However, there has been no systematic investigation of the ways in which they are being incorporated into everyday life. The project aims to address this critical gap in relation to home cooling. It will investigate how automated cooling technologies are being incorporated into household practices in Australia, and the expectations they promote, sustain and transform. The project also aims to produce important new knowledge about how to study and understand the effects of ambient and automated technologies in everyday life and their potential impact on energy consumption.Read moreRead less
Cycle Aware: Driving with Bikes. This project focuses on the education and training required by drivers to interact safely with cyclists. It uses two ontologically diverse methodologies to examine how Australian drivers become cyclist aware and the education and training necessary to foster safe driver–cyclist interactions. The project aims to provide a critical knowledge base for state and territory driver education policies and a cycle-aware module for learner drivers. These outcomes are inten ....Cycle Aware: Driving with Bikes. This project focuses on the education and training required by drivers to interact safely with cyclists. It uses two ontologically diverse methodologies to examine how Australian drivers become cyclist aware and the education and training necessary to foster safe driver–cyclist interactions. The project aims to provide a critical knowledge base for state and territory driver education policies and a cycle-aware module for learner drivers. These outcomes are intended to reduce cyclist road trauma and on-road tensions between cyclists and drivers, and to improve opportunities for active travel to tackle the growing issue of inactivity.Read moreRead less
Investigating social, built and physical environment factors for remote Indigenous communities, and their relationships with cardiometabolic outcomes. This study with 74 remote Indigenous communities will be the first to evaluate features of their social, built and physical environments in relation to cardiometabolic risks and diseases. Policy-relevant results will identify features of environments to be targeted to assist reducing chronic diseases for Indigenous peoples in remote communities.