Targeting Bone Marrow Lesions To Find Interventions In The Progression Of Osteoarthritis
Funder
National Health and Medical Research Council
Funding Amount
$467,395.00
Summary
It is essential to elucidate the underlying cause(s) of osteoarthritis because our current level of understanding of this condition has failed to produce effective treatments. Lesions in the bone under the cartilage (BMLs), seen using MRI, have strong potential value for the objective monitoring and management of OA. However, because the nature of BMLs is not well understood, the aim of this application is to perform a comprehensive study of BMLs in OA bone.
Discovery Early Career Researcher Award - Grant ID: DE140100751
Funder
Australian Research Council
Funding Amount
$379,506.00
Summary
How health shapes young children’s academic outcomes, and opportunities to intervene. Every year, about 280,000 Australian children make the crucial transition from preschool to formal education. Within this population, there is a wide range of learning capabilities and levels of preparedness. Children who have difficulties during the early years have greater risk of poorer academic and social outcomes. This project aims to determine how children's academic outcomes are shaped by common physical ....How health shapes young children’s academic outcomes, and opportunities to intervene. Every year, about 280,000 Australian children make the crucial transition from preschool to formal education. Within this population, there is a wide range of learning capabilities and levels of preparedness. Children who have difficulties during the early years have greater risk of poorer academic and social outcomes. This project aims to determine how children's academic outcomes are shaped by common physical health problems during the early years of school and how best to address these problems within the traditional school setting. This will inform future research as to the opportunities to help all children have the best opportunity to learn so they can reach their academic potential.Read moreRead less
The Role Of GRHL-3, A Mammalian Homologue Of Drosophila Grainyhead, In Neural Tube Development
Funder
National Health and Medical Research Council
Funding Amount
$496,500.00
Summary
Spina bifida and anencephaly are two common human congenital malformations that form part of a wide spectrum of mutations known collectively as neural tube defects (NTDs). Patients with the most severe form of spina bifida have a failure of the vertebral column and skin to close over the spinal cord and therefore suffer from limb paralysis and marked bladder and bowel dysfunction. Infants with anencephaly have an open cranial vault and failure of normal brain development and die within the first ....Spina bifida and anencephaly are two common human congenital malformations that form part of a wide spectrum of mutations known collectively as neural tube defects (NTDs). Patients with the most severe form of spina bifida have a failure of the vertebral column and skin to close over the spinal cord and therefore suffer from limb paralysis and marked bladder and bowel dysfunction. Infants with anencephaly have an open cranial vault and failure of normal brain development and die within the first few hours of life. These abnormalities occur frequently (1-1000 live births) and are a direct result of failure of the neural tube to close during embryogenesis. NTDs are influenced by both environmental and genetic factors. The best characterised environmental factor is the dietary supplement folate, which when administered before conception results in a reduction in the incidence of spina bifida. The genetic complexity is evidenced by the array of mouse genetic mutations that give rise to NTDs. One of these mouse mutations, known as Curly tail (ct), has served as the major animal model of human NTDs. This is because the ct mice are resistant to folate administration (like most of the cases of spina bifida currently seen in patients) and because the mice seem to have normal development in virtually all other organ systems. Ironically, the genetic mutation that causes the curly tail phenotype has remained undiscovered for over 50 years. We have now identified the gene mutated in the curly tail mice. This gene is highly conserved in humans suggesting that it will play a similar role in neural tube development in man. The gene, known as GRHL-3, is a descendant of a fly gene critical for development of the nervous system in that organism. The studies we propose here will examine the developmental pathways involved in normal neural tube closure in mice and humans and will impact on our understanding of these devastating congenital malformations.Read moreRead less
Indigenous persistence in formal learning. This project will improve knowledge of the learning experiences of Indigenous students transiting from TAFE to university studies. The results will have significant implications for the ways Indigenous students can be supported in their studies in order to achieve better quality learning experiences as well as learning outcomes.
Collaborative learning in Australia and China. This project aims to investigate aspects of learning for which “the social” is the most fundamental and useful level of explanation, modelling and instructional intervention. Interactive problem solving and learning are priorities in contemporary education, but have proven difficult to research. This project will use Australian and Chinese research facilities to investigate social interactions and classroom learning by strategically orchestrating co ....Collaborative learning in Australia and China. This project aims to investigate aspects of learning for which “the social” is the most fundamental and useful level of explanation, modelling and instructional intervention. Interactive problem solving and learning are priorities in contemporary education, but have proven difficult to research. This project will use Australian and Chinese research facilities to investigate social interactions and classroom learning by strategically orchestrating conditions for collaborative problem solving and knowledge construction by mathematics students in two very different cultures and pedagogical traditions. Outcomes from this project are expected to identify and optimise the function of social interaction in learning.Read moreRead less
Building a bridge into preschool in remote Northern Territory communities. The focus of this project is the engagement of remote Indigenous children and families in a culturally appropriate, evidence-based early childhood education and care program that provides an opportunity to close the gap between Indigenous and non-Indigenous school achievement.
Centre For Research Excellence In Childhood Language
Funder
National Health and Medical Research Council
Funding Amount
$2,485,324.00
Summary
Although most children acquire speech and language skills comparatively effortlessly, it has become increasingly apparent that many do not. More importantly, this sizeable group accounts for great subsequent population health, social and economic burden. Research in the field has been underfunded and fragmented, resulting in evidence gaps, limited capacity, and disparate guidance for policy-makers. We will address these issues, acting as a vehicle and an ongoing catalyst for internationally-comp ....Although most children acquire speech and language skills comparatively effortlessly, it has become increasingly apparent that many do not. More importantly, this sizeable group accounts for great subsequent population health, social and economic burden. Research in the field has been underfunded and fragmented, resulting in evidence gaps, limited capacity, and disparate guidance for policy-makers. We will address these issues, acting as a vehicle and an ongoing catalyst for internationally-competitive research.Read moreRead less
Improving regional secondary students' learning and well-being. Given the academic under-performance and lower life opportunities of Australian regional and rural students compared to their metropolitan counterparts, this research has the potential to make a significant social, cultural and economic contribution to the community. This research will be useful in developing an evidence-based framework to guide policy and practice in implementing an effective systematic approach to regional educati ....Improving regional secondary students' learning and well-being. Given the academic under-performance and lower life opportunities of Australian regional and rural students compared to their metropolitan counterparts, this research has the potential to make a significant social, cultural and economic contribution to the community. This research will be useful in developing an evidence-based framework to guide policy and practice in implementing an effective systematic approach to regional education and, where appropriate, other contexts. The research's economic benefit centres on gains for individuals, local communities, and the nation in enhancing regional students' academic achievements, sense of well-being and aspirations; leading to more productive citizens.Read moreRead less
Global childhoods: Life-worlds and educational success in Australia and Asia. This project aims to investigate how everyday life-worlds of year four students (nine-ten years of age) in Australia, Hong Kong and Singapore shape children’s orientations to educational success. Situated in the global cities of Melbourne, Sydney, Hong Kong and Singapore, the study explores connections between policy contexts, school experiences and everyday activities of children growing up in the Asian Century. Findi ....Global childhoods: Life-worlds and educational success in Australia and Asia. This project aims to investigate how everyday life-worlds of year four students (nine-ten years of age) in Australia, Hong Kong and Singapore shape children’s orientations to educational success. Situated in the global cities of Melbourne, Sydney, Hong Kong and Singapore, the study explores connections between policy contexts, school experiences and everyday activities of children growing up in the Asian Century. Findings will advance knowledge of factors that contribute to children’s understandings of how their experiences in and out of school prepare them for futures in a global world. This will enable policy-makers, educators and parents to provide improved learning opportunities in children’s lives.Read moreRead less
Neural Control Of Behavioural State And Cognition - Role Of Nucleus Incertus And Relaxin-3
Funder
National Health and Medical Research Council
Funding Amount
$600,771.00
Summary
Dementia and mental illness are significant social and economic burdens worldwide and knowledge of underlying causes and more effective therapies are required. Our research is using preclinical models to characterize a little studied neural network in the control of arousal states, rhythmic brain activity, and learning and memory. Our findings could advance the development of improved treatments for cognitive deficits in degenerative, age-related and psychiatric disorders.