The Role Of Central Haemodynamics In Type 2 Diabetes Mellitus-related Brain Disease
Funder
National Health and Medical Research Council
Funding Amount
$899,704.00
Summary
Type 2 Diabetes Mellitus is associated with stiffening of major blood vessels which may allow the transmission of harmful pressure to the small vessels of the brain. This may in turn be responsible for damage to brain cells and a greater risk of dementia. This study will use state-of-the art techniques to test this theory. If true, it may open opportunities to reduce the risk of brain disease in diabetes by using therapies to reduce arterial stiffening.
The Derwent project: immersive digital media visualisations for the representational problems of complex and remote environments. The Derwent Project will create new ways to visualise the complex natural and cultural history of Tasmania’s Derwent River system. This vast and often inaccessible environment includes Aboriginal and colonial heritage alongside ten hydroelectric developments. Its multiple layers of space and time present new opportunities to synthesise artistic and scientific paradigm ....The Derwent project: immersive digital media visualisations for the representational problems of complex and remote environments. The Derwent Project will create new ways to visualise the complex natural and cultural history of Tasmania’s Derwent River system. This vast and often inaccessible environment includes Aboriginal and colonial heritage alongside ten hydroelectric developments. Its multiple layers of space and time present new opportunities to synthesise artistic and scientific paradigms of representation by drawing on geography, history, and archaeology. The outcome will be innovative forms of immersive time-based digital imaging that evocatively reveal hidden layers of environmental information to both specialist and general audiences.Read moreRead less
Cellular mechanisms that protect against copper-bound beta-amyloid. This project will investigate some of the brain’s own mechanisms for protecting itself against Alzheimer’s disease. Understanding these mechanisms will be important for developing future therapeutic strategies for treating Alzheimer’s disease.
Discovery Early Career Researcher Award - Grant ID: DE120100729
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Brain connectivity during movement planning and execution in young and older adults. Ageing is associated with a reduced ability to undertake everyday movement tasks, resulting in loss of independence and frequent injuries due to falls. This research will improve our understanding of the brain mechanisms underlying movement control, with the aim of maintaining older people's quality of life and reducing health costs to the nation.
Evaluation of a multidimensional cognitive enhancement training program for healthy older adults. The percentage of the Australian population aged 65 years and over is projected to increase considerably over the next 50 years. The increased number of older Australians will have a major economic cost in terms of income support and the provision of health services. It is of high socioeconomic importance, therefore, to promote functional independence in this group. The implementation of cognitive e ....Evaluation of a multidimensional cognitive enhancement training program for healthy older adults. The percentage of the Australian population aged 65 years and over is projected to increase considerably over the next 50 years. The increased number of older Australians will have a major economic cost in terms of income support and the provision of health services. It is of high socioeconomic importance, therefore, to promote functional independence in this group. The implementation of cognitive enhancement programs that may slow age-related cognitive decline and, thereby, maximise quality of life and independence for a long as possible will have significant national benefit.Read moreRead less
The Tasmanian Healthy Brain Project: A Longitudinal Intervention Study To Reduce The Risk Of Ageing-related Cognitive Decline And Dementia
Funder
National Health and Medical Research Council
Funding Amount
$878,792.00
Summary
It has been proposed that engagement in purposeful complex mental stimulation provides protection against dementia. The Tasmanian Healthy Brain Project (THBP) is a unique, large-scale prospective trial that examines whether university-level study in older adult population reduces ageing-related cognitive decline and risk of dementia. This project will also examine how an individual’s genetic profile may influence the potential benefits of complex mental stimulation as well as risk of dementia.
Age-related changes in brain activation: Indicators of deficiency, maturity, or compensation? It is well established that cognitive and motor performance decline with advancing age. With an aging population, it is of significant socioeconomic importance to facilitate healthy ageing. To promote functional independence in everyday life for as long as possible, a better understanding of brain changes associated with aging is essential. The project will use state-of-the-art neurophysiological techni ....Age-related changes in brain activation: Indicators of deficiency, maturity, or compensation? It is well established that cognitive and motor performance decline with advancing age. With an aging population, it is of significant socioeconomic importance to facilitate healthy ageing. To promote functional independence in everyday life for as long as possible, a better understanding of brain changes associated with aging is essential. The project will use state-of-the-art neurophysiological techniques to examine individual differences in the brain's response to cognitive aging and their association with task performance. Determination of why some individuals show resilience to aging will inform the development of intervention techniques to improve cognitive and motor functions in the aged.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE170101514
Funder
Australian Research Council
Funding Amount
$372,000.00
Summary
The control of neuroplasticity in the brain. This project aims to determine how neuroplasticity – the brain’s ability to remodel and make new circuits – is controlled in both excitatory and inhibitory neurons. This capacity, vital for all cognitive functions, diminishes as people age. It is imperative to determine neuroplasticity’s mechanisms and how and why they change, but it is not known how both excitatory and inhibitory neurons contribute to neuroplasticity and how these dynamic alterations ....The control of neuroplasticity in the brain. This project aims to determine how neuroplasticity – the brain’s ability to remodel and make new circuits – is controlled in both excitatory and inhibitory neurons. This capacity, vital for all cognitive functions, diminishes as people age. It is imperative to determine neuroplasticity’s mechanisms and how and why they change, but it is not known how both excitatory and inhibitory neurons contribute to neuroplasticity and how these dynamic alterations are controlled. Understanding neuroplasticity is vital for learning, memory and healthy ageing throughout life.Read moreRead less
The effects of maternal attachment, marital satisfaction and sensitivity to infants on infants attachment and adjustment: A longitudinal-structural equation study. This study will examine how family and attachment factors effect the adjustment of infant at 24 months of age. A longitudinal study, using structural equation method, will examine how maternal attachment and marital satisfaction when infants are 4 months of age will effect maternal parenting behaviors two months later, and how all thr ....The effects of maternal attachment, marital satisfaction and sensitivity to infants on infants attachment and adjustment: A longitudinal-structural equation study. This study will examine how family and attachment factors effect the adjustment of infant at 24 months of age. A longitudinal study, using structural equation method, will examine how maternal attachment and marital satisfaction when infants are 4 months of age will effect maternal parenting behaviors two months later, and how all three of these measures will effect infant attachment 6 months later. It will then examine how all four of these measures will effect the adjustment of infants 12 months later. The study will have important implications for early intervention and prevention of psychological problems in infants and children.Read moreRead less
Predicting health, well-being, and educational success in emerging adults: An 8 year longitudinal study. This project will inform the community about factors that affect the psychological, physical, academic, and employment outcomes of emerging adults. It will improve our knowledge of why some young people do not reach their full potential. The project will provide a comprehensive assessment of factors associated with well-being across several domains. It will better equip and assist professiona ....Predicting health, well-being, and educational success in emerging adults: An 8 year longitudinal study. This project will inform the community about factors that affect the psychological, physical, academic, and employment outcomes of emerging adults. It will improve our knowledge of why some young people do not reach their full potential. The project will provide a comprehensive assessment of factors associated with well-being across several domains. It will better equip and assist professionals to identify early those youth at risk of having poor psychological, health, and employment prospects post-school. The project will inform the development of intervention programs for young people and maximise their overall adjustment and well-being several years later.Read moreRead less