Melanotransferrin: A “Missing Link” And A Novel Pharmacological Target For Treatment
Funder
National Health and Medical Research Council
Funding Amount
$613,848.00
Summary
Despite >30 years of research, the precise function of the protein, melanotransferrin (MTf), is unknown. However, we have breakthrough evidence that MTf stimulates WNT signalling as a major driver in cancer progression. We will investigate this hypothesis, which will underpin new cancer therapies. Indeed, we designed a new class of drugs that target the WNT pathway via up-regulating the WNT inhibitor, NDRG1. This drug (DpC) inhibits MTf expression to block tumour cell growth and metastasis.
Reasons and Rationality. The project explains how we assess the truth and falsehood of everyday claims about what people have reason to do. It also explains what legitimizes our practice of praising and blaming people for their success and failure at doing what we think they have reason to do. In so doing it provides a foundation for both our ordinary practice of holding people responsible, and for the more institutionalised counterpart of this ordinary practice in the law.
Sea level around Australia: fingerprints of melting ice sheets. The project aims to derive regional information on sea-level changes around the Australian coastline. The project plans to use a new technique to combine tide gauge and satellite observations of sea level with information on the spatially varying contributions of melting polar ice sheets, thermal expansion of the oceans and exchanges of water between continents and oceans. It also plans to create new software to enable time-varying ....Sea level around Australia: fingerprints of melting ice sheets. The project aims to derive regional information on sea-level changes around the Australian coastline. The project plans to use a new technique to combine tide gauge and satellite observations of sea level with information on the spatially varying contributions of melting polar ice sheets, thermal expansion of the oceans and exchanges of water between continents and oceans. It also plans to create new software to enable time-varying estimates of the contributions of these sources, from which the changes in sea level over the past century can be reconstructed at any location, including in places where no local observations have been made. This would provide Australian communities with the best possible information regarding sea-level changes in their own region.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE210100028
Funder
Australian Research Council
Funding Amount
$3,000,000.00
Summary
Australian Membership of the International Ocean Discovery Program. This proposal is for an 18-month membership of the International Ocean Discovery Program (IODP), the world’s largest collaborative research program in Earth and Ocean sciences. The Program studies the history and current activity of the Earth by conducting seagoing coring expeditions and monitoring of instrumented boreholes, using globally unique infrastructure that Australians would otherwise have no access to. Program outcomes ....Australian Membership of the International Ocean Discovery Program. This proposal is for an 18-month membership of the International Ocean Discovery Program (IODP), the world’s largest collaborative research program in Earth and Ocean sciences. The Program studies the history and current activity of the Earth by conducting seagoing coring expeditions and monitoring of instrumented boreholes, using globally unique infrastructure that Australians would otherwise have no access to. Program outcomes include understanding past global environmental change on multiple time scales, the deep biosphere, plate tectonics, formation and distribution of resources, and generation of hazards. These outcomes are paramount to Australia’s national science and research priorities, and societal and economic prosperity.Read moreRead less
The Role And Underlying Mechanisms Of Constitutional Epigenetic Silencing In Cancer Predisposition
Funder
National Health and Medical Research Council
Funding Amount
$218,617.00
Summary
Familial and young onset bowel and uterine cancer are usually caused by the inheritance of spelling mistakes in the genetic code within a set of cancer-protection genes. Recently, some patients were identified with their gene switched off by paralysing chemicals instead. This study aims to identify additional cancer cases with gene paralysis, determine if this arises in the presence or absence of a genetic change in front of the gene, and how gene paralysis is transmitted to the next generation.
Robotic investigation of water optical properties in the Southern Ocean. The project aims to improve our understanding of light–matter interactions in the waters of the Southern Ocean (SO), in particular the role of phytoplankton and associated material of biological origin. Phytoplankton are the energy source for the food web and a critical component of carbon cycling in the SO. However, their dynamics in the SO cannot be quantified using satellite observations because bio-optical data processi ....Robotic investigation of water optical properties in the Southern Ocean. The project aims to improve our understanding of light–matter interactions in the waters of the Southern Ocean (SO), in particular the role of phytoplankton and associated material of biological origin. Phytoplankton are the energy source for the food web and a critical component of carbon cycling in the SO. However, their dynamics in the SO cannot be quantified using satellite observations because bio-optical data processing algorithms perform poorly due to a lack of field data. This project seeks to remedy this by improving understanding of SO bio-optics, and by providing novel algorithms of known uncertainty, based on in situ data.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE160100067
Funder
Australian Research Council
Funding Amount
$10,000,000.00
Summary
Australian Membership of the International Ocean Discovery Program. Australian membership of the International Ocean Discovery Program:
This project is for a 5-year membership of the International Ocean Discovery Program, the world’s largest collaborative research program in earth and ocean sciences addressing international priorities. The program conducts seagoing coring expeditions and monitoring of instrumented boreholes to study the history and current activity of the Earth, recorded in sed ....Australian Membership of the International Ocean Discovery Program. Australian membership of the International Ocean Discovery Program:
This project is for a 5-year membership of the International Ocean Discovery Program, the world’s largest collaborative research program in earth and ocean sciences addressing international priorities. The program conducts seagoing coring expeditions and monitoring of instrumented boreholes to study the history and current activity of the Earth, recorded in sediments and rocks below the seafloor. The program’s aims include understanding past global environments on multiple time scales, the deep biosphere, plate tectonics, occurrence and distribution of resources, and generation of hazards. Several multinational expeditions are scheduled and planned in our marine jurisdiction and within the Australasian region. Read moreRead less
The Epigenetics of Sex in the Dragon. Genetic codes do not directly translate to phenotypes -- environment acts through epigenetics to modify development. We use advanced molecular techniques to examine how epigenetics responds to temperature to reverse sex in our novel animal model, the dragon lizard. How does the cell sense temperature? Once the extrinsic signal is captured, how does it influence chromatin modification to release or suppress key genes in the sex differentiation pathway? Which ....The Epigenetics of Sex in the Dragon. Genetic codes do not directly translate to phenotypes -- environment acts through epigenetics to modify development. We use advanced molecular techniques to examine how epigenetics responds to temperature to reverse sex in our novel animal model, the dragon lizard. How does the cell sense temperature? Once the extrinsic signal is captured, how does it influence chromatin modification to release or suppress key genes in the sex differentiation pathway? Which sex genes are targets? Epigenetic enzymes are astonishingly conserved, providing exciting opportunities to draw from human systems to unravel novel signatures of temperature-induced sex switching in reptiles. This project will advance knowledge of developmental programming generally.Read moreRead less
Trust and Distrust in Social Epistemic Networks. This project aims to discover critically-needed understandings of the social causes and consequences of ‘fake news’. It will do this by investigating and mapping the relationship between ‘epistemic vices’ and people’s acceptance of misinformation and disinformation (e.g. conspiracy theories). It will bring together approaches from experimental philosophy, natural language processing, social network analysis, and normative reflection to provide new ....Trust and Distrust in Social Epistemic Networks. This project aims to discover critically-needed understandings of the social causes and consequences of ‘fake news’. It will do this by investigating and mapping the relationship between ‘epistemic vices’ and people’s acceptance of misinformation and disinformation (e.g. conspiracy theories). It will bring together approaches from experimental philosophy, natural language processing, social network analysis, and normative reflection to provide new insights regarding distrust and intellectual vice, thus significantly advancing knowledge of the ‘dark side’ of social epistemology. Results will lead to urgently required guidance regarding the features of social networks that exacerbate or buffer against the manifestation of these vices.Read moreRead less
Special Research Initiatives - Grant ID: SR200100008
Funder
Australian Research Council
Funding Amount
$20,000,000.00
Summary
The Australian Centre for Excellence in Antarctic Science. The Centre will revolutionise predictions of the future of East Antarctica and the Southern Ocean. Changes in the Antarctic will be profoundly costly to Australia, including sea-level and fisheries impacts; but the speed and scale of future change remains poorly understood. A new national-scale and interdisciplinary Centre is required to understand the complex interactions of the ocean, ice sheets, atmosphere and ecosystems that will gov ....The Australian Centre for Excellence in Antarctic Science. The Centre will revolutionise predictions of the future of East Antarctica and the Southern Ocean. Changes in the Antarctic will be profoundly costly to Australia, including sea-level and fisheries impacts; but the speed and scale of future change remains poorly understood. A new national-scale and interdisciplinary Centre is required to understand the complex interactions of the ocean, ice sheets, atmosphere and ecosystems that will govern Antarctica’s future. The Centre will combine new field data with innovative models to address Australia’s Antarctic science priorities, train graduate students, develop leaders, engage the public, and enable major economic benefit as Australia adapts to climate change in the coming years and beyond.Read moreRead less