Examining The Metabolic And Cognitive Deficits Caused By Insulin Resistance In The Ventral Striatum
Funder
National Health and Medical Research Council
Funding Amount
$400,372.00
Summary
Brain insulin resistance is thought to cause metabolic and cognitive deficits, but the underlying neural mechanisms remain elusive. This project addresses this gap in our knowledge by examining how brain insulin resistance disrupts the metabolic regulation of food intake and the cognitive control of actions. The outcomes will provide new insights in disorders characterised by brain insulin resistance such as obesity and dementia.
Melanotransferrin: A “Missing Link” And A Novel Pharmacological Target For Treatment
Funder
National Health and Medical Research Council
Funding Amount
$613,848.00
Summary
Despite >30 years of research, the precise function of the protein, melanotransferrin (MTf), is unknown. However, we have breakthrough evidence that MTf stimulates WNT signalling as a major driver in cancer progression. We will investigate this hypothesis, which will underpin new cancer therapies. Indeed, we designed a new class of drugs that target the WNT pathway via up-regulating the WNT inhibitor, NDRG1. This drug (DpC) inhibits MTf expression to block tumour cell growth and metastasis.
The Structure And Function Of The Apical Domain In Insulin Secreting Beta Cells.
Funder
National Health and Medical Research Council
Funding Amount
$571,741.00
Summary
Loss of control of insulin secretion is causal in diabetes and therefore its understanding is a key goal to shed light on the disease. We have recently identified a new domain in the insulin secreting cells, called the apical domain. This proposal will define the role of this apical domain in controlling insulin secretion. The outcomes could provide new insights into how diabetes develops and new targets for therapies.
Improving Linkages For Chronic Disease Prevention In Indigenous Communities: A Quality Improvement Approach.
Funder
National Health and Medical Research Council
Funding Amount
$318,768.00
Summary
Primary health care and public health are often conceived as two entities providing complementary services within the health system. This research aims to better understand how to link these complementary services by using quality improvement methods and to identify successful interventions that facilitate these linkages in the prevention of chronic disease in Indigenous communities.
The Final Common Channel: Measurement Of Nerve Excitability In Epilepsy.
Funder
National Health and Medical Research Council
Funding Amount
$301,376.00
Summary
Epilepsy may be due to either one single genetic mutation or a combination of several gene-environment interactions, affecting how ion channels function. It is not possible to directly interrogate channels in the living human brain but, because similar channels are found in peripheral nerve, much may be learned about aberrant channel function from peripheral nerve. This project aims to measure peripheral nerve excitability in epilepsy patients, using it as a marker of the final common pathway of ....Epilepsy may be due to either one single genetic mutation or a combination of several gene-environment interactions, affecting how ion channels function. It is not possible to directly interrogate channels in the living human brain but, because similar channels are found in peripheral nerve, much may be learned about aberrant channel function from peripheral nerve. This project aims to measure peripheral nerve excitability in epilepsy patients, using it as a marker of the final common pathway of channel dysfunction.Read moreRead less
Hydrological changes in Australia and the South Pacific. This project plans to use stalagmites from the South–West Pacific to generate continuous rainfall records for the last 2000 years. Stalagmites contain uncorrupted data that are not available in other archives, and provide unparalleled accurate chronologies. The spatial and temporal variations of the data may highlight the interplay of climate drivers, such as El Niño Southern Oscillation, and how they change the distribution of rainfall in ....Hydrological changes in Australia and the South Pacific. This project plans to use stalagmites from the South–West Pacific to generate continuous rainfall records for the last 2000 years. Stalagmites contain uncorrupted data that are not available in other archives, and provide unparalleled accurate chronologies. The spatial and temporal variations of the data may highlight the interplay of climate drivers, such as El Niño Southern Oscillation, and how they change the distribution of rainfall in the Pacific. This knowledge would increase our scientific understanding and enable better predictions of the recurrence of droughts and wet events in Australia.Read moreRead less
Dual Targeting Of The Androgen Receptor For Effective And Durable Control Of Lethal Prostate Cancer
Funder
National Health and Medical Research Council
Funding Amount
$946,177.00
Summary
Preventing binding of androgens to the androgen receptor is the mainstay treatment for advanced prostate cancer, but resistance inevitably develops and the disease becomes lethal. We will develop a new drug that targets a part of the androgen receptor unrelated to its androgen binding function to overcome resistance to current therapy. As this drug will be effective in all stages of prostate cancer, it has high potential to improve survival outcomes for men with prostate cancer.
The Great Barrier Reef in 2100. Our research aims to answer fundamental geomorphic questions about the future of coral reefs, focusing on the Great Barrier Reef (GBR). We will develop cutting-edge, fully open-source numerical models to quantify the eco-morphodynamic evolution of the GBR under IPCC climate-change scenarios. Our geomorphic numerical models will consider biotic/abiotic feedbacks including synergistic effects of multiple stressors such as waves, temperature, acidification and sedime ....The Great Barrier Reef in 2100. Our research aims to answer fundamental geomorphic questions about the future of coral reefs, focusing on the Great Barrier Reef (GBR). We will develop cutting-edge, fully open-source numerical models to quantify the eco-morphodynamic evolution of the GBR under IPCC climate-change scenarios. Our geomorphic numerical models will consider biotic/abiotic feedbacks including synergistic effects of multiple stressors such as waves, temperature, acidification and sediment transport, at individual reef scales. We will model the future of the GBR’s ecosystem-services, allowing for a quantum leap in the geomorphic knowledge and understanding of coral reef ecosystems. Expected outcomes include a gamechanger tool for future management of the GBR.Read moreRead less
Reconstructing changes in atmospheric circulation over the mid-latitudes of the Southern Hemisphere during the past 3000 years. The climate of the mid-latitudes of the southern hemisphere is of global significance and yet past changes have proved difficult to reconstruct due to the dearth of records. Working across the Southern Ocean region using tree rings, lake sediments and ice cores, the project will produce the first comprehensive reconstruction spanning the last 3000 years.
Developing Salient Messages For Indigenous Tobacco Control In Rural Aboriginal Smokers
Funder
National Health and Medical Research Council
Funding Amount
$117,331.00
Summary
I am a General Practitioner with a keen interest in smoking cessation particularly for Aboriginal people, who have a high rate of smoking. Media messages are not to date being completely effective in this group, so I am investigating how to make more relevant and persuasive messages to support Indigenous smokers and their families (importantly pregnant smokers) to become smoke-free and encourage them to use effective treatments to do so.