Hybridisation leading to lost sex: genomic and experimental insights. The project intends to apply advanced genomics to two classic Australian systems and quantitative genetics to one to address long-standing questions about why asexual reproduction is rare. It aims to test for rapid changes in genomes accompanying hybrid-origins of asexuals and whether this new diversity enables their ongoing evolution. The significance is that support for this hypothesis would challenge current theory for why ....Hybridisation leading to lost sex: genomic and experimental insights. The project intends to apply advanced genomics to two classic Australian systems and quantitative genetics to one to address long-standing questions about why asexual reproduction is rare. It aims to test for rapid changes in genomes accompanying hybrid-origins of asexuals and whether this new diversity enables their ongoing evolution. The significance is that support for this hypothesis would challenge current theory for why sex is so common. The expected outcome is to understand how variation is generated in natural populations with different ways of reproducing. Benefits would include significant contributions to global science, evolutionary training and potential applications in using hybridisation to manage threatened species or pests.Read moreRead less
Biofocussed Prostate Cancer RadioTherapy (BiRT): A Personalised Approach To Delivering The Right Dose To The Right Place
Funder
National Health and Medical Research Council
Funding Amount
$753,565.00
Summary
We propose a new approach to treating prostate cancer with radiotherapy to move from the standard whole prostate treatment to a personalised treatment that varies radiation intensity throughout the prostate. We will mathematically combine features that influence radiotherapy effect from advanced imaging, clinical and biopsy information. This model will map out the radiotherapy dose required at each part of the prostate, to maximise killing of the cancer whilst minimising harm to normal tissue
Understanding climate and harvest induced changes in fish life histories. This project aims to quantify the cumulative impacts of harvest and climate change across marine fishes and ecosystems. The project expects to generate new knowledge in this area by coupling the rich biological information archived in fish ear bones, with targeted multi-generation experiments and predictive modelling. Expected outcomes include fundamental insights into how human-induced environmental change affects fish gr ....Understanding climate and harvest induced changes in fish life histories. This project aims to quantify the cumulative impacts of harvest and climate change across marine fishes and ecosystems. The project expects to generate new knowledge in this area by coupling the rich biological information archived in fish ear bones, with targeted multi-generation experiments and predictive modelling. Expected outcomes include fundamental insights into how human-induced environmental change affects fish growth and maturation, and a subsequent critical evaluation of the sensitivity of fisheries models to trends in these life-history traits. This should provide significant benefits to fisheries and ecosystem management, ensuring they remain productive and resilient in a time of rapid environmental change.Read moreRead less
Large-scale three dimensional deformation of the lithosphere by subduction and mantle flow. We will be modelling of the dynamics of the Earth's crust and shallow lithosphere in response to the huge stresses created by plate motions. For Australia these stresses are transmitted from the distant plate boundaries, but they have a direct controlling influence on the evolution of the petroleum rich basins of Australia. These basins have reached maturity; further exploration will be in deep water wher ....Large-scale three dimensional deformation of the lithosphere by subduction and mantle flow. We will be modelling of the dynamics of the Earth's crust and shallow lithosphere in response to the huge stresses created by plate motions. For Australia these stresses are transmitted from the distant plate boundaries, but they have a direct controlling influence on the evolution of the petroleum rich basins of Australia. These basins have reached maturity; further exploration will be in deep water where geophysical prospecting methods are unreliable. Model-driven "exploration geodynamics" methods such as those we are developing will be needed to support traditional exploration techniques in these areas.Read moreRead less
Social and environmental selection on female ornaments and armaments. Darwin's theory of sexual selection is remarkably successful in explaining how elaborate signals evolved in male animals, but it is unclear whether similar processes drive the evolution of female signals. This project aims to conduct empirical and comparative tests of hypotheses for female trait elaboration, capitalising on inter- and intra-specific variation in female signal form, social organisation and signalling environmen ....Social and environmental selection on female ornaments and armaments. Darwin's theory of sexual selection is remarkably successful in explaining how elaborate signals evolved in male animals, but it is unclear whether similar processes drive the evolution of female signals. This project aims to conduct empirical and comparative tests of hypotheses for female trait elaboration, capitalising on inter- and intra-specific variation in female signal form, social organisation and signalling environments. The project could generate new insight into the processes that promote and constrain phenotypic diversity in nature.Read moreRead less
Locating the mobile: intergenerational locative media practices in Tokyo, Melbourne and Shanghai. From providing convenience at a fingertip to helping criminal investigations, using locative media has become an essential part of everyday life for individuals, families, businesses and government. Responding to this nascent phenomenon, this project will provide the first cross-cultural, intergenerational study of locative media use.
Three dimensional computational models of geological basin and hinterland evolution incorporating lithospheric mantle and surface processes. Petroleum exploration in deepwater areas offshore Australia is becoming increasingly important as more accessible, shallow water oil reserves near exhaustion. Geological simulation is an important tool for understanding deep water basins where geophysical imaging techniques are less effective. This project will develop 3D computational models relevant to un ....Three dimensional computational models of geological basin and hinterland evolution incorporating lithospheric mantle and surface processes. Petroleum exploration in deepwater areas offshore Australia is becoming increasingly important as more accessible, shallow water oil reserves near exhaustion. Geological simulation is an important tool for understanding deep water basins where geophysical imaging techniques are less effective. This project will develop 3D computational models relevant to understanding the development and evolution of geological basins and the sediments that fill them. The models will be integrated with available offshore data for potentially prospective Australian basins in the Northwest Shelf and the Southern Australian margin.Read moreRead less
Young Australians and the promotion of alcohol on social media. This project aims to determine how young people engage with alcohol and nightlife marketing on social media platforms like Facebook, Instagram, and Snapchat. Companies now leverage the power of social media to create advertisements that are made and shared by young people, targeted to them in particular times, places and contexts, and are thus difficult to monitor and regulate. The project will use computational, big social data app ....Young Australians and the promotion of alcohol on social media. This project aims to determine how young people engage with alcohol and nightlife marketing on social media platforms like Facebook, Instagram, and Snapchat. Companies now leverage the power of social media to create advertisements that are made and shared by young people, targeted to them in particular times, places and contexts, and are thus difficult to monitor and regulate. The project will use computational, big social data approaches and youth informants to assess the pervasiveness of branding on social media and how it shapes youth cultures. This work will extend media and cultural studies and support the development of effective monitoring and regulation of online marketing in general, with a particular focus on alcohol.Read moreRead less
Theory and Applications of Computer-Intensive Statistical Methods. The availability of powerful computing equipment has had a dramatic impact on statistical methods and thinking. It has motivated development of novel approaches to data analysis, whose conception
and appreciation, even their application, often demand sophisticated and complex theoretical methods. In this context, the project will develop new approaches to solving non-standard statistical problems. These techniques will eithe ....Theory and Applications of Computer-Intensive Statistical Methods. The availability of powerful computing equipment has had a dramatic impact on statistical methods and thinking. It has motivated development of novel approaches to data analysis, whose conception
and appreciation, even their application, often demand sophisticated and complex theoretical methods. In this context, the project will develop new approaches to solving non-standard statistical problems. These techniques will either have direct application to solving practical problems of national or community concern, or provide a better understanding of the nature of such problems.Read moreRead less
Centre for Mathematical and Statistical Modelling of Complex Systems. This Centre, formed by a group of high-profile researchers, brings expertise from linked but hitherto disparate areas together. It will place Australia at the forefront of research into complex systems.
The mission of the Centre is to stimulate research in mathematical and statistical modelling of complex systems and to encourage cross-fertilisation of ideas and techniques. The specific objectives are
- to formulate and ana ....Centre for Mathematical and Statistical Modelling of Complex Systems. This Centre, formed by a group of high-profile researchers, brings expertise from linked but hitherto disparate areas together. It will place Australia at the forefront of research into complex systems.
The mission of the Centre is to stimulate research in mathematical and statistical modelling of complex systems and to encourage cross-fertilisation of ideas and techniques. The specific objectives are
- to formulate and analyse mathematical and statistical models for natural and artificial complex systems,
- to use these models to develop an understanding of the behaviour of these systems
- to incorporate this understanding into strategies for management and control.Read moreRead less