Ascorbate and glutathione integrate the control of grapevine development. This project aims to make a step-change in understanding how the growth of woody perennial crops is regulated. The study of herbaceous annual plants has established that the antioxidants, ascorbate and glutathione, are important in regulating every step of plant development. However, this cannot readily translate to perennial life cycles. This project will develop novel genetic tools in grapevine that enable functional stu ....Ascorbate and glutathione integrate the control of grapevine development. This project aims to make a step-change in understanding how the growth of woody perennial crops is regulated. The study of herbaceous annual plants has established that the antioxidants, ascorbate and glutathione, are important in regulating every step of plant development. However, this cannot readily translate to perennial life cycles. This project will develop novel genetic tools in grapevine that enable functional studies of these antioxidants in a perennial plant for the first time. It will investigate how ascorbate and glutathione regulate the development of grapevine, and how these functions integrate with hormone and energy metabolism. The outcomes will advance our ability to manage perennial crops in current and future climates.Read moreRead less
Climate Driven Shifts In Benthic Habitat Composition As A Potential Demographic Bottleneck For Western Rocklobster: Understanding The Role Of Recruitment Habitats To Better Predict The Under-size Lobster Population For Fishery Sustainability
Funder
Fisheries Research and Development Corporation
Funding Amount
$433,791.00
Summary
The marine heat waves (MHW) of 2010/11, 2011/12 and 2012/13 provide a benchmark with which to investigate changes in habitat composition and potential flow on effects to the fishery.
A 2018 independent review of the science used for stock assessment of the fishery recommended that studies should be undertaken to
a) investigate the impacts of the previous MHW on juvenile recruitment to the fishery and,
b) to better understand the role of habitat composition in recruitme ....The marine heat waves (MHW) of 2010/11, 2011/12 and 2012/13 provide a benchmark with which to investigate changes in habitat composition and potential flow on effects to the fishery.
A 2018 independent review of the science used for stock assessment of the fishery recommended that studies should be undertaken to
a) investigate the impacts of the previous MHW on juvenile recruitment to the fishery and,
b) to better understand the role of habitat composition in recruitment
To understand the impact of habitat change on the fishery, either through warming events or changes in coastal processes, we need an increased understanding of the role of habitat on the survivorship and growth of puerulus, post-puerulus, juvenile and adult life stages of lobster.
In the 40 year time-series of puerulus settlement index a very strong relationship has persisted between puerulus abundance and commercial lobster catches 3 - 4 years larter (de lestang et al., 2010). An undersize catch rate index, based on historical (1985 - present) catch-rate records, evidenced the existence of a strong correlation between puerulus and undersize catch rate (de Lestang pers. com.). However, two-four years after the MHW of 2010/11, this relationship degraded, with the observed catch rate of lobsters being far less than expected at northern locations of the fishery. Although the relationship has now started to return to its historical form, the severity and longevity of its departure are cause for concern and highlight the marked impact future MHW or changes in coastal processes could have on the fishery.
Change in the extent and configurations of coastal habitats is already occurring in response to natural physical forcing (coastal processes) and accelerated by climate change related stressors. It is crucial to have a detailed knowledge of how habitat change affects survival and recruitment key life-stages of the western rock lobster, so these can be taken into consideration for management practices that ensure the sustainability of the fishery. Such information is currently lacking. Objectives: 1. The overall objective is to evaluate the implications of habitat change for the western rock lobster fishery, by determining the relative importance of habitat for the survivorship and growth of critical western rock lobster life stages, to inform the interpretation of existing settlement and recruitment metrics where and when habitat change also occurs. This will be examined via four linked objectives: 2. Synthesise evidence of habitat change: use novel and historical habitat imagery and other remote sensing datasets to determine the spatial extent of habitat loss and recovery, either attributed to 2011/2012 marine heat wave or changes in coastal processes. 3. Investigate fine-scale correlations in anomalies between predicted and observed undersize catch rate index and areas of habitat loss and recovery, either attributed to 2011/2012 marine heat waves or changes in coastal processes. 4. Evaluate evidence of essential benthic habitat for juvenile lobster, by measuring how habitat quality (cover and composition) influences lobster survival. 5. Create a spatial index of essential habitats to inform the interpretation of existing settlement and recruitment metrics. Read moreRead less
Developmental functions of oxygen and redox cues in plants. This project aims to transform our understanding of the regulation of meristem functions, with a central hypothesis that plant cell quiescence (repressed cell division) is governed by oxygen and oxidation/reduction (redox)-dependent cues. Meristems are the growing tips of plants, and thus the fundamental unit of plant growth and productivity. This project will develop new knowledge of how plants integrate changes in the environment to r ....Developmental functions of oxygen and redox cues in plants. This project aims to transform our understanding of the regulation of meristem functions, with a central hypothesis that plant cell quiescence (repressed cell division) is governed by oxygen and oxidation/reduction (redox)-dependent cues. Meristems are the growing tips of plants, and thus the fundamental unit of plant growth and productivity. This project will develop new knowledge of how plants integrate changes in the environment to regulate meristem activity. This project will define new paradigms of how oxygen and redox status interact with energy and other cues to regulate decisions to grow or quiesce. This will underpin the development of new strategies to optimise crop management and productivity, improve the efficiency of inputs, and reduce the risk of decision making in crop production.Read moreRead less
Advancing Health Economic Evaluation Measurement And Design To Support Priority Setting For Vulnerable Children
Funder
National Health and Medical Research Council
Funding Amount
$645,205.00
Summary
I bring well developed and unique research skills in child health economics, which is concerned with making sure the health system runs fairly and without waste. This research will make significant advancements in economic evaluation methods to ensure we can fairly evaluate health interventions for children. It will assess equity in how health care is funded for children and provide new information to support a fairer health system for children.
Addressing Evidence Gaps And Developing A Novel Treatment To Reduce The Burden Of Post-traumatic Knee Osteoarthritis
Funder
National Health and Medical Research Council
Funding Amount
$645,205.00
Summary
Arthritis caused by knee injury has a devastating personal and economic impact. Research is needed to develop strategies to prevent arthritis and improve outcomes for people living with arthritis. This research will improve treatment of knee injury to reduce arthritis risk, understand why some people are more likely to get knee arthritis, and develop a new treatment to improve outcomes for people living with knee arthritis. A clinical trial will determine if this treatment achieves this aim.
Uncovering the transgenerational dimension of ageing. Despite over a century of research on the biology of ageing, one intriguing aspect of ageing – the widely observed tendency for older parents to produce offspring with reduced lifespan and fitness – remains poorly understood. Such effects could be a major source of variation in individual fitness, could play a role in the evolution of ageing, and could impact human health. Building on recent discoveries by CI Bonduriansky’s research group and ....Uncovering the transgenerational dimension of ageing. Despite over a century of research on the biology of ageing, one intriguing aspect of ageing – the widely observed tendency for older parents to produce offspring with reduced lifespan and fitness – remains poorly understood. Such effects could be a major source of variation in individual fitness, could play a role in the evolution of ageing, and could impact human health. Building on recent discoveries by CI Bonduriansky’s research group and others, this project’s aims will address significant questions about the mechanisms mediating these effects, the roles of mothers vs. fathers, and the role of the ambient environment. This project will also contribute new theory on the evolutionary implications of such effects. Read moreRead less
The fitness consequences of age-dependent changes in cognitive abilities. This project aims to investigate health-related topics in invasive fish. The evolution of large brains suggests that smarter individuals have more offspring due to natural and sexual selection. This project aims to test if the ability to perform cognitively challenging tasks predicts reproductive success. In addition, many life history traits show a trade-off between early and late life performance. This project will test ....The fitness consequences of age-dependent changes in cognitive abilities. This project aims to investigate health-related topics in invasive fish. The evolution of large brains suggests that smarter individuals have more offspring due to natural and sexual selection. This project aims to test if the ability to perform cognitively challenging tasks predicts reproductive success. In addition, many life history traits show a trade-off between early and late life performance. This project will test this prediction to see if individuals with above average cognitive performance when young are below average when old, that is faster 'cognitive senescence', or whether some individuals stay relatively smarter than others throughout their lives.Read moreRead less
Youth, religion and sexuality: digital media, school cultures, exemptions. This project aims to understand the knowledges and practices about sexuality and religion that form the everyday worlds of young people who are religious. This should provide significant new knowledge about a key time in the development of a young person’s identity via a nationwide, deep yet comparative approach. Expected outcomes include strategic health policy and curriculum development advice that responds to current d ....Youth, religion and sexuality: digital media, school cultures, exemptions. This project aims to understand the knowledges and practices about sexuality and religion that form the everyday worlds of young people who are religious. This should provide significant new knowledge about a key time in the development of a young person’s identity via a nationwide, deep yet comparative approach. Expected outcomes include strategic health policy and curriculum development advice that responds to current debates around religious exemptions to anti-discrimination law and creates better education and health care for religious and LGBTIQ+ youth. Benefits will include increased wellbeing for religious LGBTIQ+ youth, conservatively religious and newly arrived youth communities in Australia.Read moreRead less
Early start arts programmes to counter radicalisation. This project aims to strengthen interfaith relationships, through youth arts workshops that generate positive images of Muslim and non-Muslim Australian youth belonging together. Anxiety about violent extremism can stigmatise Muslim-Australian youth, but the arts can transform negative effects and amplify feelings of belonging. This project will create early childhood and primary interfaith arts intervention workshops to develop interfaith b ....Early start arts programmes to counter radicalisation. This project aims to strengthen interfaith relationships, through youth arts workshops that generate positive images of Muslim and non-Muslim Australian youth belonging together. Anxiety about violent extremism can stigmatise Muslim-Australian youth, but the arts can transform negative effects and amplify feelings of belonging. This project will create early childhood and primary interfaith arts intervention workshops to develop interfaith bonds at crucial developmental stages. It will also develop a public art campaign featuring images from the workshops about Muslim children belonging to Australian culture. The project has potential economic, social and cultural benefits for Australia.Read moreRead less
Can sexual conflict contribute to a resolution of the paradox of sex? Despite over a century of research, it remains unclear why most animals can reproduce only via sex. An exciting new hypothesis proposes that sexual conflict can promote sexual reproduction and inhibit asexual strategies, suggesting a potential solution to this long-standing paradox. Building on my research expertise, and using a native Australian insect species in which the role of sexual conflict can be studied in natural pop ....Can sexual conflict contribute to a resolution of the paradox of sex? Despite over a century of research, it remains unclear why most animals can reproduce only via sex. An exciting new hypothesis proposes that sexual conflict can promote sexual reproduction and inhibit asexual strategies, suggesting a potential solution to this long-standing paradox. Building on my research expertise, and using a native Australian insect species in which the role of sexual conflict can be studied in natural populations, this ambitious project aims to test this hypothesis for the first time. This research will expand knowledge in the biological sciences by helping to answer one of the most challenging questions in evolutionary biology. This work will also contribute to efforts to monitor Australia's unique insect fauna.Read moreRead less