Macrophage Polarisation And Control Of Pulmonary Inflammation.
Funder
National Health and Medical Research Council
Funding Amount
$895,494.00
Summary
As key immune cells, macrophages are polarised to phenotypes that turn inflammation on or off. In cystic fibrosis, defective macrophage polarisation enhances inflammation and prevents lung repair. We are defining the molecules and cellular pathways that control this process and identifying targets for existing drugs that can be used to reprogram macrophages and restore lung repair to improve patient outcomes.
A New Master Adaptor Protein For Toll-like Receptor Signalling
Funder
National Health and Medical Research Council
Funding Amount
$869,288.00
Summary
Certain proteins on the surface of cells are able to sense danger and infection. These receptors use adaptor proteins to enable cells to respond appropriately. We have discovered a new adaptor that controls receptor signalling in inflammation. This new master adaptor likely has widespread roles in infection and inflammation. We aim to understand how this adaptor works, and to identify ways of blocking its actions. These studies may help us to control inflammation underpinning many diseases.
Innate Immune Signalling In Mycobacterium Tuberculosis Infection
Funder
National Health and Medical Research Council
Funding Amount
$562,857.00
Summary
Tuberculosis (TB) is a major global health threat that causes 1.5 million deaths every year. This study will characterise a new molecular control mechanism that optimises the immune response to the bacteria that cause TB and determine how it contributes to controlling the infection. Such knowledge is essential to help improve patient management and develop better treatments for this devastating disease.
Macrophages are important cells at the front-line of immunity where one of their main roles is to release anti-bacterial proteins. We will study the macrophage molecules, subcellular organelles and pathways that help to release these proteins to kill bacteria and fight infection. Our studies will identify new cellular targets for boosting immunity and treating inherited diseases with defective macrophage function.
Optimal Source Control in Urban Water Cycle Management. Major opportunities exist to improve the management of the urban water cycle by better use of source control technology such as the use of rainwater tanks and water-sensitive design. This program will optimise the use of this technology at three scales, allotment, subdivision and regional, using genetic algorithms, parallel computing and shadow pricing. The aim is to minimise community lifecycle costs subject to sustainable use of ecosystem ....Optimal Source Control in Urban Water Cycle Management. Major opportunities exist to improve the management of the urban water cycle by better use of source control technology such as the use of rainwater tanks and water-sensitive design. This program will optimise the use of this technology at three scales, allotment, subdivision and regional, using genetic algorithms, parallel computing and shadow pricing. The aim is to minimise community lifecycle costs subject to sustainable use of ecosystems and maintenance of public health standards. The benefits include national savings of the order of $2 billion and significantly reduced demand on water supply and stormwater infrastructure and its supporting ecosystems.Read moreRead less
Macrophages are white blood cells that provide front line defence against infection by initiating inflammatory responses by ingesting or phagocytosing microbes and by releasing soluble messengers (cytokines) to recruit other immune cells. These defensive functions require extensive trafficking of proteins within the macrophages. Protein trafficking is orchestrated in part by a family of membrane fusion proteins called SNAREs. By defining the relevant SNAREs, we have recently discovered a much ac ....Macrophages are white blood cells that provide front line defence against infection by initiating inflammatory responses by ingesting or phagocytosing microbes and by releasing soluble messengers (cytokines) to recruit other immune cells. These defensive functions require extensive trafficking of proteins within the macrophages. Protein trafficking is orchestrated in part by a family of membrane fusion proteins called SNAREs. By defining the relevant SNAREs, we have recently discovered a much acclaimed and novel pathway that allows efficient, combined cytokine secretion and phagocytosis in macrophages. Our studies proposed here will now expand on this discovery by comparing the phagocytic process, in terms of SNARE-mediated membrane and cytokine trafficking, for a wide range of microbes, highlighting differences that could provide new avenues for drug development. Moreover, since our strategy of using SNAREs to investigate and map trafficking pathways has proven so successful, we will now launch a major large-scale initiative to study ALL SNARE-mediated trafficking pathways in macrophages using a discovery pipeline of assays, including live cell imaging, we have developed. This will provide valuable information on many SNAREs including those associated with disease, and will elucidate trafficking pathways governing all macrophage actions in immunity, including cytokine secretion and antigen presentation. All of these pathways are highly relevant to current drug targets being used clinically or studied in inflammatory disease and for the development of vaccines.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0989067
Funder
Australian Research Council
Funding Amount
$950,000.00
Summary
The future of palaeoclimate and archaeological research in Australia: next generation instrumentation for chronology and environmental reconstruction. The outcomes of this project will promote a better understanding of Australia's arid continent and its surrounding marine environment, contribute to studies of global climate change, and provide new insights into the response of fragile ecosystems to such events and processes. The project addresses directly the National Research Priority 'Water - ....The future of palaeoclimate and archaeological research in Australia: next generation instrumentation for chronology and environmental reconstruction. The outcomes of this project will promote a better understanding of Australia's arid continent and its surrounding marine environment, contribute to studies of global climate change, and provide new insights into the response of fragile ecosystems to such events and processes. The project addresses directly the National Research Priority 'Water - a critical resource', 'Responding to climate change and variability', 'Overcoming soil loss, salinity and acidity', 'Sustainable use of Australia's biodiversity' and 'Understanding our region and the world'. It provides a consortium-type platform for highly productive collaborative research and training across eight universities and one research organisation in Australia.Read moreRead less
Reconstructing the historical frequency and intensity of Australian droughts: A multi-species dendrochronological approach. Drought directly and indirectly impacts every Australian. Severe droughts devastate rural communities, lead to increased water restrictions and bushfire activity, slows the national economy and threatens diverse ecosystems. Our research will improve understanding of where, when, and how intensely droughts have occurred across eastern Australia in the past. The results will ....Reconstructing the historical frequency and intensity of Australian droughts: A multi-species dendrochronological approach. Drought directly and indirectly impacts every Australian. Severe droughts devastate rural communities, lead to increased water restrictions and bushfire activity, slows the national economy and threatens diverse ecosystems. Our research will improve understanding of where, when, and how intensely droughts have occurred across eastern Australia in the past. The results will provide unique insights into the processes that generate Australian droughts and how future droughts might be anticipated. The results will provide farmers, hydrologists, and policy-makers with better data on long-term variability in water supplies to improve local, regional, and national water planning initiatives and infrastructure development.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE130100295
Funder
Australian Research Council
Funding Amount
$373,679.00
Summary
Forecasting the future of flood and drought in Australia using multi-century tree-ring and isotope chronologies from the tropics. The effects of El Nino on Australian floods and droughts in a globally changing climate is unclear because we lack long climate records from the past. This project will measure tree-ring and isotope records using kauri pine to advance our understanding of El Nino's effects on the frequency and intensity of drought and floods in Australia.
Quantifying the El Niño-Indian Ocean Dipole system using high-resolution coral palaeoclimate archives. The ocean surrounding Indonesia is the warmest on Earth and a major source of energy for global atmospheric circulation. Understanding the role of the Warm Pool in future climate change is of key importance, but highly controversial because the potential extent of its variability is largely unknown. To address this issue, this project will provide the first major geochemical investigation of ....Quantifying the El Niño-Indian Ocean Dipole system using high-resolution coral palaeoclimate archives. The ocean surrounding Indonesia is the warmest on Earth and a major source of energy for global atmospheric circulation. Understanding the role of the Warm Pool in future climate change is of key importance, but highly controversial because the potential extent of its variability is largely unknown. To address this issue, this project will provide the first major geochemical investigation of recently discovered ancient corals in Indonesia using state-of-the-art microanalytical techniques. Outcomes from these palaeoclimate records will advance our understanding of global climate change, rainfall variability related to the El Nino - Indian Ocean Dipole system, and Australian drought.Read moreRead less