Pharmaceutical Opioid Prescription For Chronic Pain In Australia: Trajectories Of Prescribing, Risk Of Adverse Events, And Predictors Of Harm
Funder
National Health and Medical Research Council
Funding Amount
$1,086,274.00
Summary
There is concern about rising levels of opioid analgesic prescribing in Australia. This study is important because it will provide evidence about long term outcomes for patients using opioid therapy for chronic non-malignant pain. It will examine prescribing patterns and link them to other health outcomes such as overdose. We will also study patients beginning opioid therapy for chronic pain and follow them up over 2 years to examine outcomes such as pain relief and medication side effects.
Early Life And Contemporary Influences On Body Composition, Mental Health, And Chronic Disease Risk Markers In The Aboriginal Birth Cohort
Funder
National Health and Medical Research Council
Funding Amount
$3,117,044.00
Summary
The Aboriginal Birth Cohort study has been following the health of Aboriginal babies in the Northern Territory for the last 30 years. The participants were healthy till adolescence, but overweight and risk factors of diseases such as diabetes, kidney and heart disease are emerging. This follow-up will show when and whether these risk factors develop into disease, which factors are protective and which identify early those most at risk of developing diseases that cause the gap in life expectancy.
Preconception Determinants Of Child Health And Development: A 4-year Follow Up Of Offspring Born To The Australian Temperament Project
Funder
National Health and Medical Research Council
Funding Amount
$1,065,799.00
Summary
This project will follow offspring born to a large population cohort study that has tracked the mental health and wellbeing of around 2000 participants across 30 years prior to parenthood. The aim is to understand how the lives parents lived before conception, as well as events during pregnancy, shape social and emotional outcomes for their children. Results will inform radically new approaches to promoting child health and development across generations.
Cancer Genomics; Psychosocial, Behavioural And Ethical Issues And Outcomes, Two Inter-related Longitudinal Studies
Funder
National Health and Medical Research Council
Funding Amount
$506,654.00
Summary
Over 1/3 of patients with cancer will die of their disease. Genomics offers hope of more tailored risk management and treatment, but will only realize its promise if patients understand, cope with, inform relatives about, and make informed decisions based on, genomic results. This study will be the first internationally to explore the knowledge, attitudes, preferences, experiences and outcomes of cancer patients who undergo genomic testing and their relatives, over time.
Australian Longitudinal Study Of Heroin Dependence: An 18-20yr Prospective Cohort Study Of Mortality, Abstinence, And Psychiatric And Physical Health Comorbidity
Funder
National Health and Medical Research Council
Funding Amount
$1,210,319.00
Summary
The burden associated with heroin dependence is undeniable. But little is known about the natural history and long-term course of heroin dependence; knowledge that is critical for informing the development of new treatment interventions, health care planning and service delivery. We propose to extend our study of 615 Australians with heroin dependence, recruited in 2001-2002, to 18-20 years follow-up to answer critical questions about the long-term impact of this condition.
The Evolution Of Childhood Obesity And Its Relationship To Adult Sleep Disordered Breathing
Funder
National Health and Medical Research Council
Funding Amount
$870,842.00
Summary
This project will characterise Obstructive Sleep Apnoea (OSA) in early adulthood. It will assess the prevalence of OSA in a well characterised cohort (the Raine Cohort), representative of the population of young adults in Western Australia. It will define the clinical picture and risk factors associated with abnormal breathing during sleep and will use the extensive longitudinal data collected from 18 weeks gestation until 23 years of age to quantify early life developmental and environmental pr ....This project will characterise Obstructive Sleep Apnoea (OSA) in early adulthood. It will assess the prevalence of OSA in a well characterised cohort (the Raine Cohort), representative of the population of young adults in Western Australia. It will define the clinical picture and risk factors associated with abnormal breathing during sleep and will use the extensive longitudinal data collected from 18 weeks gestation until 23 years of age to quantify early life developmental and environmental predictors that can inform public health policy.Read moreRead less
Implementing Multiple Imputation With Sensitivity Analysis In Large-scale Longitudinal Studies
Funder
National Health and Medical Research Council
Funding Amount
$473,507.00
Summary
Missing data arise in most research studies and if not handled appropriately can mean the study results are not correct. With researchers now conducting larger and longer studies the challenges posed by missing data are increasing. In this grant we study a powerful technique for handling missing data, which in its current form often cannot be applied effectively in large studies. By developing this approach we will improve the accuracy of results from large-scale epidemiological studies.
The RADAR Project: Identifying Early Warning Signals On The Pathways To Alcohol Use Disorder
Funder
National Health and Medical Research Council
Funding Amount
$884,321.00
Summary
The transition from alcohol initiation to an alcohol use disorder is a crucial yet under-studied research area. The current project will characterise the natural history of alcohol use disorder and identify modifiable factors that increase or decrease the likelihood of developing an alcohol use disorder once alcohol use begins. This information will guide prevention of, and early intervention for, this disabling disorder.
Australian Longitudinal Study Of Heroin Dependence: A 11 Year Prospective Cohort Study Of Mortality, Abstinence, Criminality And Psychiatric Comorbidity Among Heroin Users
Funder
National Health and Medical Research Council
Funding Amount
$372,295.00
Summary
To conduct the longest and most comprehensive prospective follow-up of Australian heroin users. A 11 year follow-up presents the unique opportunity to examine: Mortality rates, remission rates, criminal histories and levels of psychopathology ; Predictive factors of long term remission, mortality, criminality and the health service utilisation associated with heroin use careers.
The Diamond Cohort Study - Better Management Of Those At Risk Of Persistent And Disabling Depression
Funder
National Health and Medical Research Council
Funding Amount
$1,563,309.00
Summary
Diamond began in 2005 to follow over 500 people with depressive symptoms to document and describe the nature and course of depression and its’ management over a decade of a participant’s life. Our findings will help us to understand the factors associated with depression recovery, relapse and persistence. We will inform clinical practice by developing a tool to assist GPs to identify those at risk of persistent and disabling depression, to enable better treatments.