Gene Mining For Novel Molecular Determinants Of The Skeleton
Funder
National Health and Medical Research Council
Funding Amount
$633,447.00
Summary
Musculoskeletal conditions affect over 6 million Australians and research has shown that genetic background strongly influences development of these disorders. This project will identify genes that have a role in controlling bone and joint architecture. Identification of these genes will assist in the development of treatments targeting bone disorders and allow screening for these genes to provide an opportunity for people to take preventative action to improve bone and joint health.
Impact Of An Ivermectin Mass Drug Administration Program Against Endemic Scabies And Strongyloidiasis
Funder
National Health and Medical Research Council
Funding Amount
$1,289,786.00
Summary
Overseas studies suggest sustainable and long term benefits can be obtained through the use of ivermectin in mass drug administration programs to control parasitic infections. Our study will be a critical first step in establishing if such a program can be successful in a remote Indigenous community setting, where the disease burden from scabies and strongyloidiasis (threadworm infections) is very high.
Thermal enhancement strategies and development of a high-performance micro-scale heat exchanger for thermoelectric refrigeration with large cooling loads. Traditional refrigeration essentially utilises CFC-refrigerants which are potent atmospheric pollutants causing widespread ecological damage. Devoid of such adversities, electronic heat pumping mechanism of thermoelectric principle offers a practical ?CFC-free? alternative for conventional cooling methods. While the current thermoelectric te ....Thermal enhancement strategies and development of a high-performance micro-scale heat exchanger for thermoelectric refrigeration with large cooling loads. Traditional refrigeration essentially utilises CFC-refrigerants which are potent atmospheric pollutants causing widespread ecological damage. Devoid of such adversities, electronic heat pumping mechanism of thermoelectric principle offers a practical ?CFC-free? alternative for conventional cooling methods. While the current thermoelectric technology adequately meets light cooling demand, its potential for heavy-duty refrigeration is critically undermined by ill-developed methods for dissipating heat from thermoelectric modules to coolants, and remains grossly under-utilised. The proposed work will devise novel heat transfer techniques for raising thermoelectric cooling thresholds to suit large heat loads and develop a thermally enhanced micro-scale heat exchanger for application in commercial thermoelectric refrigeration.Read moreRead less
Physical, Lifestyle And Psychosocial Determinants Of Spinal Pain Development In Adolescents
Funder
National Health and Medical Research Council
Funding Amount
$682,800.00
Summary
This project aims to understand the development of back and neck pain in adolescence. By the age of 16 around half of all adolescents have suffered back pain and one third have suffered neck pain. For many adolescents this pain is disabling and over a third of sufferers miss school, miss recreation and seek medical help. The current understanding of back and neck pain in adolescence is quite limited - restricting the effectiveness of initiatives to prevent adolescents having to suffer spinal pai ....This project aims to understand the development of back and neck pain in adolescence. By the age of 16 around half of all adolescents have suffered back pain and one third have suffered neck pain. For many adolescents this pain is disabling and over a third of sufferers miss school, miss recreation and seek medical help. The current understanding of back and neck pain in adolescence is quite limited - restricting the effectiveness of initiatives to prevent adolescents having to suffer spinal pain and of treatment of those adolescents unlucky enough to have an episode. Better understanding and interventions for adolescent spinal pain will also have longer term implications by reducing adult spinal pain. Four out of 5 adults will experience spinal pain. In the USA treating adult back pain is the 4th largest health care cost. Many adults with chronic back pain had their first episode during adolescence. A better understanding of spinal pain in adolescence may help prevent it developing into a lifelong disability. We will collect information from 2,000 adolescents on their experience of back and neck pain and on potential physical, lifestyle and psychosocial risk factors. We believe factors such as their posture, muscle capacity, TV and computer use, mental health and social situation all combine to influence whether a person develops back or neck pain. The project is unique as it will not only collect a broad range of information during adolescence, but will also make use of a large database of health, developmental and psychosocial information already collected from these children since birth. With a better understanding of the development of spinal pain we will be able to develop guidelines to help prevent these problems. We will also be able to develop better treatment plans for sub-groups of adolescents with a particular combination of risk factors. Together these initiatives will assist in understanding and breaking the pathway to chronic spinal pain.Read moreRead less
Functional Effects Of Polymorphic Variation Of The Aromatase (CYP19) Gene On Enzyme Activity:relationship To Disease
Funder
National Health and Medical Research Council
Funding Amount
$237,708.00
Summary
After menopause, oestrogen synthesis changes from an ovarian to an adipose source by concersion of androgens to estrogens, a process catalyzed by aromatase, the product of the CYP19 gene. We will generate mutants of the CYP19 gene that we have previously found in humans by site-directed mutagenesis and observe the effects of these mutants on aromatase function. This research will help with diagnosis and treatment of breast and other cancers and osteoporosis in humans .
Discovery Early Career Researcher Award - Grant ID: DE130101533
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
A risk-based approach to natural gas hydrates in oil and gas production. Like a cholesterol for oil and gas pipelines, gas hydrates are ice-like deposits that completely block the flow during production and are expensive to prevent as well as dangerous to remove. This proposal provides a risk-based approach to hydrate management that will increase the viability of natural gas production from fields in deep water.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE170100174
Funder
Australian Research Council
Funding Amount
$193,000.00
Summary
Acoustic levitation facility for high pressure multiphase systems research. This project aims to create a specialised acoustic levitation facility that delivers precise control of a suspended particle/droplet/bubble within a high pressure continuous phase, and simultaneous measurement of multiple bulk and interfacial properties. Acoustic levitation enables container-less experiments, offering opportunities for applied engineering and fundamental science. This acoustic levitation system will be i ....Acoustic levitation facility for high pressure multiphase systems research. This project aims to create a specialised acoustic levitation facility that delivers precise control of a suspended particle/droplet/bubble within a high pressure continuous phase, and simultaneous measurement of multiple bulk and interfacial properties. Acoustic levitation enables container-less experiments, offering opportunities for applied engineering and fundamental science. This acoustic levitation system will be integrated with a specialised Raman imaging microscope to study crystallisation, mass transfer and molecular exchange, in application areas including energy transport, carbon capture and storage, and protein nucleation. This project is expected to open new avenues in engineering, chemistry and physics.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE140101094
Funder
Australian Research Council
Funding Amount
$395,220.00
Summary
Precision Spectroscopy of CO2 Exchange in Hydrates for Clean Energy Production. Carbon dioxide capture and sequestration is a widely considered climate change mitigation strategy. Clathrate hydrates of natural gas, found in deep-water ocean sediments, represent a tremendous opportunity for simultaneous carbon dioxide sequestration and clean energy production. By injecting carbon dioxide into the hydrate reservoir, methane can be displaced and replaced by carbon dioxide. This project will use Ram ....Precision Spectroscopy of CO2 Exchange in Hydrates for Clean Energy Production. Carbon dioxide capture and sequestration is a widely considered climate change mitigation strategy. Clathrate hydrates of natural gas, found in deep-water ocean sediments, represent a tremendous opportunity for simultaneous carbon dioxide sequestration and clean energy production. By injecting carbon dioxide into the hydrate reservoir, methane can be displaced and replaced by carbon dioxide. This project will use Raman spectroscopy and nuclear magnetic resonance imaged core-flood experiments to develop a fundamental understanding of the exchange mechanisms governing the replacement of the methane molecule in the hydrate cage with carbon dioxide. This knowledge will be critical for future development of these resources to safely extract methane from sub-sea hydrates.Read moreRead less
Heat Transfer Mechanisms in an Indirectly Fired Rotary Kiln with Lifters and Its Role in Scaling. This project will apply heat transfer principles to improve and optimise the design and performance of ANSAC's innovative kiln technology for a wide range of process applications. By understanding the mechanisms of heat transfer involved in the working of the proprietary technology, major factors limiting the performance of the kiln can be identified, resulting in design criteria that link key opera ....Heat Transfer Mechanisms in an Indirectly Fired Rotary Kiln with Lifters and Its Role in Scaling. This project will apply heat transfer principles to improve and optimise the design and performance of ANSAC's innovative kiln technology for a wide range of process applications. By understanding the mechanisms of heat transfer involved in the working of the proprietary technology, major factors limiting the performance of the kiln can be identified, resulting in design criteria that link key operating parameters for the kiln scaling and performance forecast. The research outcomes will provide a scientific basis that underpins the development of an Australian technology and supports the growth of a new Australian small business, creating employment opportunities within Australia.Read moreRead less
Near zero-emission hydrogen and carbon production from natural gas and bio-methane. Hydrogen is envisaged as a clean fuel for power generation particularly for the transportation sector. In the short- and mid-term future, hydrogen will be derived from fossil fuels. Based on the conventional processes, the route from fossil fuels to hydrogen invariably produces greenhouse gases. Geosequestration is a viable technique of storing carbon dioxide but has an uncertain long-term environmental ramifi ....Near zero-emission hydrogen and carbon production from natural gas and bio-methane. Hydrogen is envisaged as a clean fuel for power generation particularly for the transportation sector. In the short- and mid-term future, hydrogen will be derived from fossil fuels. Based on the conventional processes, the route from fossil fuels to hydrogen invariably produces greenhouse gases. Geosequestration is a viable technique of storing carbon dioxide but has an uncertain long-term environmental ramification. In contrast, our proposed technique avoids the production of greenhouse gases and, instead, engenders high value added graphitized carbon as a by-product. Given the relative stability and value of graphitized carbon, our catalytic cracking process provides another option to geosequestration.Read moreRead less