A Vulvar Cancer Cluster Caused By Genetic Susceptibility: Investigating The Genetic Mechanism.
Funder
National Health and Medical Research Council
Funding Amount
$1,154,342.00
Summary
Cancer of the vulva is 70 times more common in young Aboriginal women in Arnhem Land than in other women. Human Papillomavirus (HPV), which also causes cervical cancer, is the usual cause of this cancer; initial investigations have found that HPV is present in these cancers but is not the reason for the excessive incidence. This study will investigate inherited risk factors contributing to the development of this disease in this population.
Research Fellowship – Genetic Epidemiology Studies Of Hormonal Cancers To Inform Improved Healthcare
Funder
National Health and Medical Research Council
Funding Amount
$772,209.00
Summary
This study aims to identify genetic factors that influence the development of endometrial and other cancers, and to develop statistical and laboratory methods that can better determine if variation in a known cancer gene is disease-causing. The results will be used to identify and prioritise individuals at greatest risk of cancer for the most appropriate clinical management. Discovery of novel cancer genes will improve our understanding of disease development to develop future therapies.
Lung cancer is the commonest cause of cancer death worldwide. There is growing interest in the genetic causes of lung cancer. The overall aim of this research is to gain a better understanding of the steps in the genetic pathway of lung cancer spread. This knowledge is essential in the development of new targeted therapies and improvement in lung cancer prognosis.
Lung cancer is a leading cause of cancer death globally. Symptoms may not develop until disease is advanced, so it is often incurable at diagnosis. Scientific developments have greatly improved our ability to test for the changes in DNA structure and function responsible for this deadly disease and its progression. This study examines whole lung cancer genomes then uses these findings to develop safer methods for detection based on changes in DNA sequence.