Bronchoscopic Applications Of Anatomical Optical Coherence Tomography.
Funder
National Health and Medical Research Council
Funding Amount
$408,366.00
Summary
This research proposal aims to investigate the potential utility of a novel, Australian designed dianostic laser system. A tube positioned in the lungs takes real-time images of the shape and size inside the airways. This can have both clinical and research benefits. It may help doctors choose the right size hardware when opening up cancerous airways and it will help us understand disease mechanisms of lung diseases by studying parts of the airways not previously able to be measured.
Effectiveness Of Mindfulness Based Cognitive Therapy For Preventing Depressive Relapse In Subjects At Very High Risk
Funder
National Health and Medical Research Council
Funding Amount
$643,317.00
Summary
More than one in twenty Australians experience depression in a single year and it is commonly a relapsing disorder. At least 60% of people who have had a depressive episode will have another, the vast majority within two years of the index episode, 70% of those who have had two episodes will have a third, and 90% of those with three episodes will have a fourth. The economic burden of depression in Australia has been estimated as perhaps $2.8 billion annually. Mindfulness-based cognitive therapy ....More than one in twenty Australians experience depression in a single year and it is commonly a relapsing disorder. At least 60% of people who have had a depressive episode will have another, the vast majority within two years of the index episode, 70% of those who have had two episodes will have a third, and 90% of those with three episodes will have a fourth. The economic burden of depression in Australia has been estimated as perhaps $2.8 billion annually. Mindfulness-based cognitive therapy (MBCT) is an innovative psychological treatment, combining principles of cognitive therapy and mindfulness meditation. It is designed to prevent depressive relapse in people who have recovered from depressive episodes. MBCT aims to teach people to become more aware of, and to relate differently to, their thoughts, feelings and bodily sensations; in particular, to view these thoughts and feelings as passing events in the mind rather than identifying with them. Through gaining these skills in increased awareness of thoughts and feelings, participants in the treatment learn to avoid negative ruminations, which have a powerful role in triggering relapses of depression. Primarily this study aims to examine the effectiveness of MBCT for the first time in Australians with a history of recurring depression. As a large multi-site investigation it will establish the feasibility of bringing MBCT into routine practice in both urban and rural areas of Australia. The study also aims to establish whether the mechanisms by which MBCT is proposed to work - by decreasing rumination, increasing levels of mindfulness and self-awareness - do in fact operate. We also hope to establish whether MBCT also has any impact on anxiety, another disabling condition that commonly occurs with depression. This study will enhance evidence as to whether the treatment of MBCT should be recommended routinely to sufferers with repeated episodes of major depression.Read moreRead less
The Role Of Pharmacotherapy In Prevention Of Relapse In Alcohol Dependence
Funder
National Health and Medical Research Council
Funding Amount
$422,310.00
Summary
The physical, psychological and social consequences of alcohol abuse remain a critical health problem. Every year in Australia, excessive consumption is responsible for 3,000-6,000 deaths and costs the community $6 billion. Approximately 15% of Australians abuse alcohol and 5% of men and 3% of women are alcohol dependent (addicted to alcohol). Young men are particularly affected, with 10% of all men aged 18-35 dependent on alcohol. Better treatment for alcohol dependence is urgently needed. Less ....The physical, psychological and social consequences of alcohol abuse remain a critical health problem. Every year in Australia, excessive consumption is responsible for 3,000-6,000 deaths and costs the community $6 billion. Approximately 15% of Australians abuse alcohol and 5% of men and 3% of women are alcohol dependent (addicted to alcohol). Young men are particularly affected, with 10% of all men aged 18-35 dependent on alcohol. Better treatment for alcohol dependence is urgently needed. Less severe forms of alcohol abuse frequently respond to brief screening and intervention programs. Treatment of alcohol dependence remains unsatisfactory. Most treatments lead to abstinence in only 1-3, and approximately 50% of these will relapse within 3 months of completing treatment. Two drugs (naltrexone and acamprosate) appear to interfere with the effects of alcohol on the brain that promote addiction. There is evidence that both drugs are beneficial in the treatment of alcohol dependence and both are now available in Australia. At present, no data have been reported comparing the effectiveness of these two drugs. The proposed project will compare naltrexone and acamprosate in a large carefully performed study. The study will help determine which subjects are likely to benefit from one or other of these agents. Compliance is a major problem with many medications, but is a particular problem with medications for substance abuse. The second aim of this study is to test a novel intervention to increase compliance with medications for alcohol dependent subjects. This intervention comprises 'compliance therapy', which resembles a short training course, a medication alarm, and an assertive reminder program for scheduled medical appointments. The present study will be the first to apply this type of therapy to subjects with alcohol dependence.Read moreRead less
Closing The Evidence-practice Gap In Total Knee Replacement: Optimising Evidence-based Decision-making Through A Multi-dimensional Surgeon Feedback Intervention
Funder
National Health and Medical Research Council
Funding Amount
$1,091,926.00
Summary
Total knee replacement (TKR) is one of the most successful surgeries for treating knee arthritis. With an ageing population demand for TKR will increase dramatically, placing burden on our health system. It is estimated that 25% of TKRs are performed in inappropriate candidates according to evidence-based guidelines. This project evaluates a program for surgeons that will improve adherence to using guidelines, which will improve efficiencies & equitability of this important surgical procedure.
Circulatory Biomarkers For Idiopathic Pulmonary Fibrosis: Improving Patient Outcomes
Funder
National Health and Medical Research Council
Funding Amount
$841,625.00
Summary
We are going to find molecules in the blood that would improve the diagnosis and treatment of a lung condition called Idiopathic Pulmonary Fibrosis (IPF). The project brings together well characterized patients from the Australian IPF registry, blood samples we have collected from them and cutting edge technologies to complete this project.
I am a developmental lung physiologist who specialises in understanding the factors regulating normal and abnormal lung development as well as the physiological transformation of the lung into an efficient gas-exchange organ at birth.