The Predictors Of Asthma And Lung Function Deficits In The Third Decade: Longitudinal Study Of MACS Sibships
Funder
National Health and Medical Research Council
Funding Amount
$1,176,908.00
Summary
This will be the world’s first birth cohort study to use substantial prospective data to investigate how biological, psychosocial, and environmental markers from birth will predict asthma and lung function in the third decade of life. Our findings will be crucial to the development of new policy and practice for the prevention and management of these conditions and uncover crucial risk factors for young adult asthma.
Do Exposures Before Conception Influence The Risk Of Asthma In Offspring?
Funder
National Health and Medical Research Council
Funding Amount
$688,586.00
Summary
Asthma and poor lung function are major causes of public health issues. Emerging evidence suggests adverse exposures even before the conception of a child may cause these conditions. The proposed project is part of an international study across generations to identify these factors. This study will provide novel evidence to guide interventions and identify studies to advance this area further. These original findings will be of great importance both nationally and internationally.
Novel Molecular Markers Of Lung Cancer Risk And Survival
Funder
National Health and Medical Research Council
Funding Amount
$824,765.00
Summary
Lung cancer remains the most lethal cancer worldwide, yet little is known of the risk factors beyond that of tobacco smoking and certain occupational exposures. We have assembled a large international consortium comprising 24 cohort studies and over 10,000 to validate associations between B-vitamins and lung cancer risk particularly in never and former smokers. We propose to expand this study and use the Melbourne Collaborative Cohort Study and the rest of the consortium to identify novel biomar ....Lung cancer remains the most lethal cancer worldwide, yet little is known of the risk factors beyond that of tobacco smoking and certain occupational exposures. We have assembled a large international consortium comprising 24 cohort studies and over 10,000 to validate associations between B-vitamins and lung cancer risk particularly in never and former smokers. We propose to expand this study and use the Melbourne Collaborative Cohort Study and the rest of the consortium to identify novel biomarkers of risk and survival.Read moreRead less
Determining The Role Of Vitamin D In The Development Of Asthma And Allergic Diseases In High Risk Families
Funder
National Health and Medical Research Council
Funding Amount
$351,127.00
Summary
Allergic diseases like asthma, eczema and hay-fever, prevent our children from getting a healthy start to life, and we don’t know how to prevent these conditions. Vitamin D levels may be critical in the development of childhood asthma and allergies, and they can be easily modified! Using a group of 620 children who we have followed for 20 years, we will identify the role of vitamin D levels in the development of allergic conditions, and factors that modify these relationships.
What Are The Lifetime Clinical Predictors And Risk Factors For Multiple Phenotypes Of Adult Asthma, COPD And Sleep Disordered Breathing? Following Up The TAHS Cohort From 1st To 6th Decade
Funder
National Health and Medical Research Council
Funding Amount
$1,950,689.00
Summary
Breathing gets impaired and impact on the productivity and quality of life when chronic respiratory diseases rise with ageing. Adult chronic respiratory diseases are major causes of illness and death but there are still many gaps in knowledge on how best to prevent and manage these diseases. The proposed program will provide evidence to guide health policy and clinical management of these diseases. These original findings will be of great importance both nationally and internationally.
This project will update the Wittenoom cohorts by tracing cancers and deaths in Australia and Italy. This will improve risk estimates of lung cancer and mesothelioma. In particular we will see if that risk declines with more than 40 years since exposure, in collaboration with Italian colleagues. We will continue developing an interactive community website to act as a support platform, a layman's bridge to medical research knowledge, public health information and an archive of personal stories.
Investigating Early Life Exposure To Plastic Products In Australia And Subsequent Neurodevelopmental Effects
Funder
National Health and Medical Research Council
Funding Amount
$791,376.00
Summary
Child neurodevelopment disorders like autism are becoming more common. Recent work indicates almost all pregnant mothers in Australia harbour plastic chemicals – bisphenols and phthalates and foetus is also exposed. Human evidence is emerging that higher exposure to plastics during pregnancy may be associated with these disorders. Randomised controlled trials are not possible so high quality birth cohort studies, as proposed here, are required to investigate this issue comprehensively.
The Contribution Of Home Language Exposure To Intergenerational Transmission Of Inequality
Funder
National Health and Medical Research Council
Funding Amount
$1,281,706.00
Summary
The amount of language stimulation from parent to child could be the key driver behind intergenerational inequality. Children learn language through social interaction and this study will significantly enhance our current understanding of exposure to language in the child's home environment. The study will demonstrate how inequalities in the early years have far reaching consequences for later health and development.
Turning Points: Breaking Intergenerational Cycles Of Intimate Partner Abuse And Social Adversity
Funder
National Health and Medical Research Council
Funding Amount
$1,328,354.00
Summary
Intimate partner abuse (IPA) is estimated to affect one in four women at some stage in their lives, and to impact on the lives of at least one million Australian children annually. This study will investigate the extent to which exposure to intimate partner abuse during pregnancy and in the first 12 months postpartum predicts child outcomes in middle childhood. The study will provide foundations for better targeting and tailoring of early intervention strategies to support children at risk of ad ....Intimate partner abuse (IPA) is estimated to affect one in four women at some stage in their lives, and to impact on the lives of at least one million Australian children annually. This study will investigate the extent to which exposure to intimate partner abuse during pregnancy and in the first 12 months postpartum predicts child outcomes in middle childhood. The study will provide foundations for better targeting and tailoring of early intervention strategies to support children at risk of adverse outcomes.Read moreRead less
What Are The Clinical Predictors And Risk Factors For Impaired Child Growth And Development? Following Up The Ha Nam Cohort From Birth To 3 Years
Funder
National Health and Medical Research Council
Funding Amount
$1,189,570.00
Summary
Stunting affects about one third of children under five in developing countries and is a measure of chronic undernutrition. This project will identify pre and postnatal risk factors for impaired child growth and development by monitoring a cohort of infants in Vietnam to three years of age, and developing a predictive algorithm for early detection of those at risk of stunting. Effective preventative measures would improve child health, and prevent a huge burden of disease.