Research To Reduce Cognitive Decline And Optimise Ageing Well
Funder
National Health and Medical Research Council
Funding Amount
$753,300.00
Summary
My research program will deliver research outcomes that will improve the quality of life for older Australians, increase the life-span spent in productivity (as opposed to dependency) and reduce health-care costs. I will conduct interventions to improve the skill of older drivers so they can remain independent, and interventions to reduce cognitive decline and risk of dementia. My work will provide information and interventions for middle-aged and older adults, enabling them to age well.
Promoting Healthy Ageing Of Brain And Mind Through Epidemiology And Intervention Research
Funder
National Health and Medical Research Council
Funding Amount
$664,584.00
Summary
This project focuses on identifying ways that individuals and societies can promote healthy ageing to prevent dementia and mental health problems in later life. Large-scale longitudinal studies and intervention studies will be evaluated to identify factors that lead to healthy and unhealthy ageing.
Biomarkers For The Diagnosis And Prognostic Analysis Of Male Infertility
Funder
National Health and Medical Research Council
Funding Amount
$631,370.00
Summary
Male infertility is a common condition, affecting 1 in 15 men. Although a standard semen analysis is often performed to test whether a man is infertile, it is far from definitive. We have developed a new approach, by looking at proteins that are commonly missing from infertile sperm cells. From this analysis, we can definitively diagnose male infertility and are beginning to understand why men are becoming infertile.
Understanding And Preventing Adverse Developmental Effects Of Perinatal Infection/inflammation
Funder
National Health and Medical Research Council
Funding Amount
$621,458.00
Summary
Exposure of babies to infection or inflammation within the womb is common and is associated with preterm delivery and illness in newborns. The biggest problem for these babies is lung disease due to inflammation of the lungs before birth and/or in response to lung injury after birth. We are investigating how inflammation alters lung development, and working on developing a novel cell therapy to prevent life-threatening newborn lung disease.
Cancer remains a major cause of morbidity and mortality in the developed & developing world. Underpinning the causes of cancer are genetic and cellular changes in key structural proteins that control cell growth and movement. My research aims to discover key links in the regulation of these proteins that lead to tumour formation, metastasis and drug resistance. My goal is to use this knowledge to develop effective and less toxic treatment strategies to target difficult-to-treat cancers.
Development Of New Therapies For Respiratory Diseases And Infection
Funder
National Health and Medical Research Council
Funding Amount
$847,490.00
Summary
Prof Hansbro’s group have developed world 1st experimental models of emphysema, severe asthma infection and lung cancer. He uses them to further our understanding of these untreatable diseases. This has led to the development of new potential therapeutic approaches. Now, in discovery programs he will expand studies of pathogenesis to identify new therapeutic targets these diseases. In development and translational programs he will progress new therapies towards clinical application.
The Molecular Basis By Which IL-6 Family Cytokines And Pathogen Recognition Receptors Promote Inflammation-associated Stomach And Lung Cancer
Funder
National Health and Medical Research Council
Funding Amount
$631,010.00
Summary
Lung and stomach cancer are the 2 most lethal cancers world-wide, and represent a growing number of cancers associated with chronic inflammation. However, the genes which trigger inflammation and then promote cancer in certain people remain largely unknown. Using mouse models for these inflammation-associated cancers, together with clinical specimens, our aim is to identify specific genes of the immune system which trigger chronic inflammatory responses that lead to cancer.
I am a reproductive biologist focused on women’s reproductive health. I am studying the reasons why some women are infertile have spontaneous abortions and pregnancy complications such as pre-eclampsia. My research will define the roles of molecules that are critical in the establishment of pregnancy and the formation of a health placenta and therefore a healthy baby.
Platelets are key blood elements that are essential for the prevention of bleeding in response to injury or infection. Overactive or spontaneously active platelets cause thrombosis and blood clot formation. My laboratory has identified new physiological pathways of activation of platelet metalloproteinases, the enzymes that regulate surface levels of the prothrombotic platelet receptors. By understanding this mechanism of receptor regulation, we can uniquely target platelet receptors in people w ....Platelets are key blood elements that are essential for the prevention of bleeding in response to injury or infection. Overactive or spontaneously active platelets cause thrombosis and blood clot formation. My laboratory has identified new physiological pathways of activation of platelet metalloproteinases, the enzymes that regulate surface levels of the prothrombotic platelet receptors. By understanding this mechanism of receptor regulation, we can uniquely target platelet receptors in people with prothrombotic pathologies.Read moreRead less
An inability to control human fertility is an issue of global significance. Frequently both unwanted pregnancies and infertility result from the same origin, a lack of understanding of how germ cells are produced. Within this fellowship I will define key processes involved in the manifestation of male fertility. Further I will extend these insights into both the fertility clinic but also into human health more broadly.