Linkage Infrastructure, Equipment And Facilities - Grant ID: LE120100094
Funder
Australian Research Council
Funding Amount
$220,000.00
Summary
Macromolecular characterisation and purification facility. In-depth characterisation of (bio)macromolecules and nanomaterials is fundamental to understanding their properties and application to advanced materials and technologies. The three new instruments at this facility dedicated to the purification, separation and characterisation of these compounds will provide an essential resource for polymer/materials research.
Nanopore sensors for multiplexed, ultra-fast gene detection. The aim of this research is to develop the application of protein nanopores for multiplex identification of DNA samples for ultrafast gene detection. This is a type of barcoding of organism DNA that allows for rapid gene identification. This technology aims to address a significant need for rapid, on-the-spot identification of organisms. Applications include rapid identification of pathogenic bacteria in infections and identification o ....Nanopore sensors for multiplexed, ultra-fast gene detection. The aim of this research is to develop the application of protein nanopores for multiplex identification of DNA samples for ultrafast gene detection. This is a type of barcoding of organism DNA that allows for rapid gene identification. This technology aims to address a significant need for rapid, on-the-spot identification of organisms. Applications include rapid identification of pathogenic bacteria in infections and identification of organisms in environmental sampling. Current methods are relative slow, require DNA amplification and specialised laboratories.
This proposal aims to fine tune the properties of the large nanopore, polyC9, with respect to size and charge, as well as to identify and characterise novel large nanopores. Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE180100179
Funder
Australian Research Council
Funding Amount
$3,189,000.00
Summary
Automated high resolution and high contrast cryo -TEM for three-dimensional structural biology. This project aims to establish a facility in automated, single-particle cryo-TEM and cryo-TEM tomography (Titan Krios) that will enable atomic and molecular structure research and three-dimensional subcellular and cellular imaging. The project will span all multiscale cryo-TEM modalities from the visualisation of cells, membranes and macromolecular complexes, through to near-atomic-resolution protein ....Automated high resolution and high contrast cryo -TEM for three-dimensional structural biology. This project aims to establish a facility in automated, single-particle cryo-TEM and cryo-TEM tomography (Titan Krios) that will enable atomic and molecular structure research and three-dimensional subcellular and cellular imaging. The project will span all multiscale cryo-TEM modalities from the visualisation of cells, membranes and macromolecular complexes, through to near-atomic-resolution protein structure determination. Cryo-single particle analysis and tomography are recognised as revolutionary technologies in molecular structural biology and powerful enablers of future ground-breaking discovery. The project will deliver significant competitive advantage for Australia in leading-edge structure-based research, drug discovery, new opportunities for applied research and development, and showcasing science to the public.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE140100087
Funder
Australian Research Council
Funding Amount
$410,000.00
Summary
Advanced Macromolecular Materials Characterisation Facility (AMMCF). Advanced macromolecular materials characterisation facility: The facility will allow precise characterisation of (bio)macromolecular materials, from chemical structures and composition as a function of size or biodistribution, to film thickness in multi-layer materials, to material hydrophobicity and permeability. Novel information derived from these state-of-the-art instruments is highly valuable in understanding structure-pro ....Advanced Macromolecular Materials Characterisation Facility (AMMCF). Advanced macromolecular materials characterisation facility: The facility will allow precise characterisation of (bio)macromolecular materials, from chemical structures and composition as a function of size or biodistribution, to film thickness in multi-layer materials, to material hydrophobicity and permeability. Novel information derived from these state-of-the-art instruments is highly valuable in understanding structure-property relationships, which are crucial for the development of the next generation of advanced materials with applications in electronics, optics, sensors, membranes, nanocoatings, biomaterials and polymer therapeutics. This facility underpins the efforts of the participating institutes in increasing the quality and quantity of research outcomes.Read moreRead less
ARC Centre of Excellence in Advanced Molecular Imaging. The Centre of Excellence in Advanced Molecular Imaging will innovatively integrate physics, chemistry and biology to unravel the complex molecular interactions that define immunity. The Centre will develop new imaging methods to visualize atomic, molecular and cellular details of how immune proteins interact and
effect immune responses. Outcomes: (i) new technological innovations leading to new imaging methods and products; and (ii) fundame ....ARC Centre of Excellence in Advanced Molecular Imaging. The Centre of Excellence in Advanced Molecular Imaging will innovatively integrate physics, chemistry and biology to unravel the complex molecular interactions that define immunity. The Centre will develop new imaging methods to visualize atomic, molecular and cellular details of how immune proteins interact and
effect immune responses. Outcomes: (i) new technological innovations leading to new imaging methods and products; and (ii) fundamental advances in understanding details of immune responses in health and disease. The Centre will enable Australia to be an international leader in biological imaging, to train next
generation interdisciplinary scientists, and to provide new insights for combating common diseases that afflict society.Read moreRead less