Investigation And Modulation Of RANKL-induced Osteoclastogensis, Bone Resorption And Signaling Pathways
Funder
National Health and Medical Research Council
Funding Amount
$33,825.00
Summary
Osteoclasts are exclusively responsible for the degradation of bone matrix. RANKL is a member of a ligand-receptor system which directly regulates osteoclast differentiation and bone resorption. New treatment regime for various bone diseases have been highly sought after for many years. The identification of potential natural compounds that inhibit the formation and function of osteoclasts might serve as a useful tool for such treatment.
Brain diseases such as epilepsy and Alzheimer�s are linked to the activation of synapses, contact points between nerve cells. Synapses absorb and release neurotransmitters in the cyclic process of endocytosis & exocytosis allowing nerve cell communication. This study aims to identify the master controllers, protein kinases, which are essential to reset the process after each cycle. These proteins can be exploited as targets in drug discovery programs to treat common neurological diseases.