We will seek to address an important clinical problem in orthpaedics, namely the bone loss that commonly occurs around joint replacement prostheses. Termed peri-prosthetic osteolysis (PO), this bone loss can result in the loosening and ultimate failure and need for revision of the artificial joint components. PO is thought to be caused by the body's reaction to wear particles generated from the articulating surface of the prosthesis. However, it has not previously been possible to accurately exp ....We will seek to address an important clinical problem in orthpaedics, namely the bone loss that commonly occurs around joint replacement prostheses. Termed peri-prosthetic osteolysis (PO), this bone loss can result in the loosening and ultimate failure and need for revision of the artificial joint components. PO is thought to be caused by the body's reaction to wear particles generated from the articulating surface of the prosthesis. However, it has not previously been possible to accurately explore the relationship between prothesis wear and PO, or the progression of PO, because of a lack of techniques to image and measure the volume of PO around metal prosthesis components. We have developed a means to accurately and reproducibly measure the volume of bone loss, using CT, and will do so longitudinally in joint replacement patients to obtain the first information about the progression of PO. New computer based methods will be used concurrently to relate prosthesis wear and migration parameters to PO. Patients who come to surgery for replacement of failed prostheses will be investigated further by analysis of the tissues involved in the bone loss around prostheses. Basic science experiments will seek to understand the underlying causes of PO and the findings will be important in interpreting the clinical results. An animal model will be used to seek approaches to inhibiting the pathological response to wear particles. The significance of these studies is that they will lead to improved outcomes for joint replacement patients, increasing the interval to revision surgery, which is both extremely costly and brings an attendant morbidity and mortality.Read moreRead less
Threats to the water quality and ecosystem of Coffin Bay, South Australia. Coffin Bay (South Australia) is experiencing worsening environmental conditions despite its major economic and ecological importance. Research is needed to understand the cause of this decline, particularly in light of a recent bacterial outbreak that impacted the aquaculture industry. This multidisciplinary project aims to deliver world-leading scientific advice based on novel field techniques and innovative models of th ....Threats to the water quality and ecosystem of Coffin Bay, South Australia. Coffin Bay (South Australia) is experiencing worsening environmental conditions despite its major economic and ecological importance. Research is needed to understand the cause of this decline, particularly in light of a recent bacterial outbreak that impacted the aquaculture industry. This multidisciplinary project aims to deliver world-leading scientific advice based on novel field techniques and innovative models of this complex inverse estuary system and its surrounding catchment. The new understanding of the sources, fluxes and fate of nutrients within the bay and the surrounding catchment, arising from this project, is expected to benefit management decision-making and establish a new standard in estuarine water quality investigation.Read moreRead less
The Marketing Performance of International Subsidiaries Post Merger and Acquisition. Globalisation is a fact of life, illustrated by Australia's attempt to establish a free trade agreement (FTA) with the US and current FTAs with Singapore and Thailand. It is imperative that Australia finds out why and how its firms perform after they have been taken over or merged with a foreign firm. Especially if the Australian firm is export active, because if the Australian firm starts to perform poorly afte ....The Marketing Performance of International Subsidiaries Post Merger and Acquisition. Globalisation is a fact of life, illustrated by Australia's attempt to establish a free trade agreement (FTA) with the US and current FTAs with Singapore and Thailand. It is imperative that Australia finds out why and how its firms perform after they have been taken over or merged with a foreign firm. Especially if the Australian firm is export active, because if the Australian firm starts to perform poorly after it has been merged/acquired by the foreign firm this could have a negative impact on Australia's Balance of Payments/Balance of Trade thereby making a study of this type most timely.Read moreRead less
Examining The Impact Of Language Reclamation On Social And Emotional Well Being Among The Barngarla
Funder
National Health and Medical Research Council
Funding Amount
$1,111,633.00
Summary
Indigenous Australians are at high risk of experiencing mental illness. For many, it is the loss of land, culture, and identity that are causes of ill health. The Barngarla people of South Australia seek to reclaim their language due to its potential reinvigorating cultural identity and wellbeing. This offers a unique opportunity to document the links between language reclamation and wellness in Aboriginal people for the first time.
Improving water quality modelling by better understanding solute transport. Poor stream water quality is a critical problem in Australia and globally. Stream water quality depends directly on pathways and time taken for water to transport pollutants through catchments. Predicting these pathways is highly challenging and currently requires specialised data. This project aims to better model the movement of water from rainfall to streams, enable greatly improved use of water quality data routinely ....Improving water quality modelling by better understanding solute transport. Poor stream water quality is a critical problem in Australia and globally. Stream water quality depends directly on pathways and time taken for water to transport pollutants through catchments. Predicting these pathways is highly challenging and currently requires specialised data. This project aims to better model the movement of water from rainfall to streams, enable greatly improved use of water quality data routinely collected in Australia's catchments and thereby better predict water quality behaviour. Proposed field studies aim to support this development. The outcomes sought are improved planning and management of water quality in our rivers, lakes and estuaries, improved health of these water bodies and improved water supplies.Read moreRead less
Global implications of Australian Cretaceous faunas: biogeography, evolution and effects of climate change. Climate change is a critical issue with poorly known long-term effects. This collaboration will provide information on how marine and terrestrial faunas have responded to environmental alteration in the past. Mesozoic vertebrates make spectacular fossils that capture public attention. This collaboration will enhance public museum displays by collection and preparation of important new spec ....Global implications of Australian Cretaceous faunas: biogeography, evolution and effects of climate change. Climate change is a critical issue with poorly known long-term effects. This collaboration will provide information on how marine and terrestrial faunas have responded to environmental alteration in the past. Mesozoic vertebrates make spectacular fossils that capture public attention. This collaboration will enhance public museum displays by collection and preparation of important new specimens; many found by the investigators are already centerpieces in major museums (e.g. SA Museum). This project will also promote awareness and sustainable use of the environment through media promotion and 'earthwatch-style' ecotourism field trips; these highlight finite fossil resources as lucrative sources of tourism revenue to regional communities. Read moreRead less
Biogeography and evolution of Australia's fossil reptiles: A global perspective. Large marine reptiles such as plesiosaurs, and missing links such as legged snakes, are spectacular animals that have captured public attention. This collaboration will directly enhance public museum displays by collecting and preparing these spectacular fossils; many of the fossils found by the CIs are now centerpieces of museum displays (e.g. the SA museum). Also, it will also promote awareness and sustainable u ....Biogeography and evolution of Australia's fossil reptiles: A global perspective. Large marine reptiles such as plesiosaurs, and missing links such as legged snakes, are spectacular animals that have captured public attention. This collaboration will directly enhance public museum displays by collecting and preparing these spectacular fossils; many of the fossils found by the CIs are now centerpieces of museum displays (e.g. the SA museum). Also, it will also promote awareness and sustainable use of the environment: it will facilitate CI Kear in running earthwatch-style ecotourism field trips which promote sustainable use of finite fossil resources by making them commercially valuable to local communities as a source of tourism revenue.Read moreRead less
Funding our future: perceptions of the value of financial planning advice. This project will examine how perceptions of the value of financial planning advice are formed over time. If this is understood then both government and the industry can develop better strategies to encourage those who can benefit from financial advice to recognise and gain value from the service.
Multiscale Singularly Perturbed Control Systems. We propose to develop a unified averaging technique to analyse deterministic and stochastic multiscale singularly perturbed control systems. Such systems arise as mathematical models of real-world dynamical systems in which state variables can change their values with the rates of different orders of magnitude. The technique is based on the assumption that the system, which would describe the dynamics of the fast state variables if slow ones were ....Multiscale Singularly Perturbed Control Systems. We propose to develop a unified averaging technique to analyse deterministic and stochastic multiscale singularly perturbed control systems. Such systems arise as mathematical models of real-world dynamical systems in which state variables can change their values with the rates of different orders of magnitude. The technique is based on the assumption that the system, which would describe the dynamics of the fast state variables if slow ones were frozen, possesses certain ergodicity properties expressed in the existence of its limit occupational measures set. Conditions for the existence of such a set will be studied and its structure will be described.Read moreRead less
The reality of China's socialist market economy: the emergence of labour segmentation and inequality. Australia's current regional and economic security is predicated on China's stability and prosperity. This project provides a unique opportunity for Australian organisations and institutions to gain a better understanding of the complex economic, regulatory and social issues that surround the problem of labour segmentation and inequality in China.