Most eye diseases have a genetic contribution, whether rare disorders affecting children such as retinoblastoma or congenital cataracts through to common disorders of older people such as myopia, age-related macular degeneration or glaucoma. We will continue our successful research to find genes that cause these diseases and use this to improve patient care and prevent blindness. We will work out how families can use this genetic information to participate in trials to develop new treatments.
A new biomechanical model for understanding aging of stored Red Blood Cells. This project plans to develop a novel modelling framework to accurately represent the biomechanical properties of red blood cells (RBCs) over time under stored conditions. Stored RBCs suffer ageing-related deformability changes which impede RBC functions. The framework aims to integrate models for RBC membrane, inside haemoglobin and outside storage solution, and accounts for ageing effects by embedding time-dependent c ....A new biomechanical model for understanding aging of stored Red Blood Cells. This project plans to develop a novel modelling framework to accurately represent the biomechanical properties of red blood cells (RBCs) over time under stored conditions. Stored RBCs suffer ageing-related deformability changes which impede RBC functions. The framework aims to integrate models for RBC membrane, inside haemoglobin and outside storage solution, and accounts for ageing effects by embedding time-dependent correlations. It should provide new insights and understanding of the mechanisms of deformability changes of RBCs during stored lifespan. Therefore, it should significantly improve blood storage industry practices in terms of improving RBC storage protocols with preventative ageing strategies.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE210100975
Funder
Australian Research Council
Funding Amount
$415,775.00
Summary
Architectured ceramics to combine strength, toughness, and complex shapes. This project aims to develop ceramics that are simultaneously strong and tough, and to form them into complex shapes without compromising their mechanical properties – major challenges in science and engineering. Inspired by the internal architectures that confer these advantages on natural hard materials, it will produce novel ceramics with rationally-designed, highly-controlled dense architectures by developing a fast, ....Architectured ceramics to combine strength, toughness, and complex shapes. This project aims to develop ceramics that are simultaneously strong and tough, and to form them into complex shapes without compromising their mechanical properties – major challenges in science and engineering. Inspired by the internal architectures that confer these advantages on natural hard materials, it will produce novel ceramics with rationally-designed, highly-controlled dense architectures by developing a fast, scalable and versatile light-based 3D–4D printing technique combined with discrete element modelling. Outcomes will be toughened ceramics and new knowledge on processing-architecture-performance relationships, with significant benefits for biomaterials, defence, transport, high-temperature and aerospace applications.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0453398
Funder
Australian Research Council
Funding Amount
$161,075.00
Summary
A Non Contact Facility For Measuring Irreversible Energy, Residual Stress, and Full Field Stresses for Critical Rail Infra-Structure Assessment. To meet the national rail objectives as enunciated in the 2002 Green Paper there is an urgent requirement for a capability for: i) advanced (rail) prototype assessment, ii) rapid assessment of rail infra-structure, iii) for increasing the capacity of existing (rail) infra-structure. To address this we propose a facility with both a dissipative energy m ....A Non Contact Facility For Measuring Irreversible Energy, Residual Stress, and Full Field Stresses for Critical Rail Infra-Structure Assessment. To meet the national rail objectives as enunciated in the 2002 Green Paper there is an urgent requirement for a capability for: i) advanced (rail) prototype assessment, ii) rapid assessment of rail infra-structure, iii) for increasing the capacity of existing (rail) infra-structure. To address this we propose a facility with both a dissipative energy measurement and a 'lock in' thermograpghy capability. Recent Australian developments in thermo-elasticity enables the researchers to extend this facility to measure residual stress in complex components. The ability to measure dissipated energy, residual stress, ultrasonic waves, and full field stress will create a unique research capability.Read moreRead less
Towards autonomous structural safety prognostics: integrating in-situ imaging and predictive modelling. This project aims to advance a scientific basis for autonomous safety prognostics by developing predictive models and in-situ damage imaging principles. Development of this new health prognostic approach will overcome the significant challenge of safety assurance of composite structures in the presence of in-service damage, which is largely hidden.
Baseline-free Methods for Early Damage Diagnosis using Nonlinear Ultrasound. To address the significant limitation of existing non-destructive evaluation techniques in detecting and characterising early damage, this project aims to discover the physical nature of self-generated nonlinear waves by structural damage and to explore its potential for an entirely new class of non-destructive evaluation and structural health monitoring techniques. Major applications are expected to include a baseline- ....Baseline-free Methods for Early Damage Diagnosis using Nonlinear Ultrasound. To address the significant limitation of existing non-destructive evaluation techniques in detecting and characterising early damage, this project aims to discover the physical nature of self-generated nonlinear waves by structural damage and to explore its potential for an entirely new class of non-destructive evaluation and structural health monitoring techniques. Major applications are expected to include a baseline-free structural health monitoring technique capable of detecting and quantifying barely-visible impact damage in advanced composite materials, non-destructive evaluation of structures made by additive manufacturing, and detection of hard-to-inspect locations in unitised structures.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0347553
Funder
Australian Research Council
Funding Amount
$175,000.00
Summary
Smart Equipment for Remote Monitoring of Isolated and Mobile Infrastructure. The partners' research involves the collection and assessment of data to determine the condition, maintenance strategies and risk of failure of plant in diverse areas such as transport, cargo and packaging, mining and power. Recent advances in data processing, computing and telemetry mean that it is now possible to actually install small and rugged data acquisition equipment on remote infrastructure or mobile plant. T ....Smart Equipment for Remote Monitoring of Isolated and Mobile Infrastructure. The partners' research involves the collection and assessment of data to determine the condition, maintenance strategies and risk of failure of plant in diverse areas such as transport, cargo and packaging, mining and power. Recent advances in data processing, computing and telemetry mean that it is now possible to actually install small and rugged data acquisition equipment on remote infrastructure or mobile plant. This equipment can acquire, condition and process the signals and use wireless telemetry to transmit the data for remote assessment. The proposed infrastructure will enable the partners' research to be extended to these challenging applications.Read moreRead less