Determination Of Irradiation Dose Efficacy For Use In Impaction Grafting At Revision Joint Replacement
Funder
National Health and Medical Research Council
Funding Amount
$411,517.00
Summary
Primary hip replacement is a successful intervention for hip disease, but 10-15% of hip prostheses fail and require revision surgery within 10-15 years. At the time of revision, significant bone loss around the failed prosthesis is not uncommon. A bone reconstruction procedure, called impaction grafting, where donor bone is minced and placed in the areas of deficient bone before implanting the new prosthesis, has shown to give good results at more than ten years in some centres. A high incidence ....Primary hip replacement is a successful intervention for hip disease, but 10-15% of hip prostheses fail and require revision surgery within 10-15 years. At the time of revision, significant bone loss around the failed prosthesis is not uncommon. A bone reconstruction procedure, called impaction grafting, where donor bone is minced and placed in the areas of deficient bone before implanting the new prosthesis, has shown to give good results at more than ten years in some centres. A high incidence of early complications of this procedure have included loss of fixation within the bone. Fracture of the bone around prostheses has also reported in some centres. These events require more surgery, putting the patient at higher risk greater complications and longer rehabilitations. Recent improvements in surgical technique and donor bone preparation have improved results. A current debate questions whether the dose of irradiation can be reduced from 25 kGy, while maintaining sterility of allografts. The risk of bacterial contamination in allografts is low, and irradiation reduces the mechanical strength of the graft, contributing to complications when irradiated bone is used. The benefits of decontaminating the bone may be outweighed by the higher risk for failure due to poor bone quality and resulting prosthesis instability. We will use ISO standards to test the validity of radiation dose for sterilising bone ex vivo. In the absence of controlled human studies, our aim is also to compare the results of impaction grafting with non-irradiated bone versus bone irradiated at current doses used by Australian bone banks, and lower doses indicated by ex vivo testing. We will use a large animal model of revision hip replacement, with precise measures of prosthesis stability. The results of this study will guide clinical decisions regarding the efficacy of current bone graft preparation procedures and the use of irradiated bone in human hip replacement surgery.Read moreRead less
Computerised diffraction tomography for structural health monitoring. Structural health monitoring (SHM) offers the prospect of a quantum gain in performance and efficiency for the design and structural integrity management of high-value assets (e.g. aircraft). The aims of this project are to develop and validate efficient computational tools for:
(i) Characterising the scattering of the Lamb waves by defects or boundaries, and
(ii) Implementing robust and versatile approaches to tomographic i ....Computerised diffraction tomography for structural health monitoring. Structural health monitoring (SHM) offers the prospect of a quantum gain in performance and efficiency for the design and structural integrity management of high-value assets (e.g. aircraft). The aims of this project are to develop and validate efficient computational tools for:
(i) Characterising the scattering of the Lamb waves by defects or boundaries, and
(ii) Implementing robust and versatile approaches to tomographic imaging of laminar defects or damage from experimental/synthetic scattered field data.
This project will result in the development of a validated and versatile SHM system for quantifying damage that is analogous to computerised tomography in medical imaging.Read moreRead less
Most eye diseases have a genetic contribution, whether rare disorders affecting children such as retinoblastoma or congenital cataracts through to common disorders of older people such as myopia, age-related macular degeneration or glaucoma. We will continue our successful research to find genes that cause these diseases and use this to improve patient care and prevent blindness. We will work out how families can use this genetic information to participate in trials to develop new treatments.
Developing And Evaluating A Multimodal Antibiotic Allergy Strategy To Improve Antimicrobial Stewardship In High-risk Antibiotic Usage Populations
Funder
National Health and Medical Research Council
Funding Amount
$303,014.00
Summary
Antibiotic allergies lead to the use of inferior antibiotics and generation of “superbugs”. Antibiotic allergy testing removes up to 90% of allergies, although remains unavailable to many and unreliable in some severe antibiotic reactions. We aim to validate antibiotic allergy bedside tools and programs, and develop laboratory tests that can diagnose and prevent severe antibiotic allergies, to improve appropriate antibiotic prescribing and patient outcomes.
An Exploration Of Functional Decline And The Potential For Rehab In Patients With Advanced Non-small Cell Lung Cancer
Funder
National Health and Medical Research Council
Funding Amount
$50,000.00
Summary
Lung cancer is one of the commonest human cancers and the leading cause of cancer deaths. People with advanced cancer experience significant decline in functional capacity as their disease advances and they approach death. This decline is likely to have significant impact on quality of life. In lung cancer this decline can be exacerbated by chronic illnesses such as chronic obstructive pulmonary disease (COPD). While significant clinical benefits have been demonstrated in COPD patients with the ....Lung cancer is one of the commonest human cancers and the leading cause of cancer deaths. People with advanced cancer experience significant decline in functional capacity as their disease advances and they approach death. This decline is likely to have significant impact on quality of life. In lung cancer this decline can be exacerbated by chronic illnesses such as chronic obstructive pulmonary disease (COPD). While significant clinical benefits have been demonstrated in COPD patients with the introduction of pulmonary rehabilitation, little research has been conducted to either map the functional status of lung cancer patients or to explore the application of pulmonary rehabilitation in this setting. This study seeks to begin a program of work in this area through first exploring the characteristics of functional decline in this group and then assessing the feasibility and acceptability of a rehabilitation program specifically addressing the functional status needs identified.Read moreRead less
Novel quantitative sizing of inaccessible and hard-to-inspect defects to address the challenges posed by innovations in airframe design. Modern unitised aircraft structures cannot be reliably inspected using traditional techniques. This project will develop new techniques to quantify defects required for this innovation in aircraft component design. This research will improve the through-life support of future metallic and composite aircraft structures and improve air safety.
A Mechanistic Approach to the Compression Properties of Z-Pinned Composites. The proposed research is a fundamental investigation of the compressive mechanical properties and failure mechanisms of fibre reinforced polymer (FRP) composites reinforced with z-pins. These composites are a new material with strong potential applications in aerospace structures subject to high compressive loads, however their compressive properties are poorly understood. Using theoretical modelling, finite element an ....A Mechanistic Approach to the Compression Properties of Z-Pinned Composites. The proposed research is a fundamental investigation of the compressive mechanical properties and failure mechanisms of fibre reinforced polymer (FRP) composites reinforced with z-pins. These composites are a new material with strong potential applications in aerospace structures subject to high compressive loads, however their compressive properties are poorly understood. Using theoretical modelling, finite element analysis and experimentation, the research program will greatly enhance the fundamental understanding of the strengthening and failure mechanisms of z-pinned composites. A key outcome of the research will be design guidelines for optimising the pinning of composites for maximum structural performance in aerospace applications.Read moreRead less
A Population-based Longitudinal Assessment Of Early Life Vitamin D And Risk Of Food Allergy
Funder
National Health and Medical Research Council
Funding Amount
$466,086.00
Summary
There has been a dramatic and unexplained increase in food allergy over recent decades. The increase in food allergy may relate to a concordant increase in early vitamin D insufficiency, however this hypothesis has never been directly tested. This project will use existing/funded samples from two NHMRC funded studies to conduct a detailed investigation of (i) the determinant and predictors of early life vitamin D insufficiency; and (ii) the association of vitamin D insufficiency and food allergy ....There has been a dramatic and unexplained increase in food allergy over recent decades. The increase in food allergy may relate to a concordant increase in early vitamin D insufficiency, however this hypothesis has never been directly tested. This project will use existing/funded samples from two NHMRC funded studies to conduct a detailed investigation of (i) the determinant and predictors of early life vitamin D insufficiency; and (ii) the association of vitamin D insufficiency and food allergy.Read moreRead less
Interaction between consolidation and lubrication of biological joints. This project aims to develop a computational model to be used in conjunction with experimental studies to understand complex lubrication systems in biological joints. Nature has equipped biological joints with a remarkable ability to achieve ultralow friction even at relatively high contact force, however the mechanisms used remain uncertain. This project intends to provide a deeper, fundamental understanding of the friction ....Interaction between consolidation and lubrication of biological joints. This project aims to develop a computational model to be used in conjunction with experimental studies to understand complex lubrication systems in biological joints. Nature has equipped biological joints with a remarkable ability to achieve ultralow friction even at relatively high contact force, however the mechanisms used remain uncertain. This project intends to provide a deeper, fundamental understanding of the friction and contact mechanisms occurring in biological joints. The project outcomes could lead to bioinspired innovation in future engineering design and advancements in materials science that have the potential to significantly benefit Australian society.Read moreRead less
A new biomechanical model for understanding aging of stored Red Blood Cells. This project plans to develop a novel modelling framework to accurately represent the biomechanical properties of red blood cells (RBCs) over time under stored conditions. Stored RBCs suffer ageing-related deformability changes which impede RBC functions. The framework aims to integrate models for RBC membrane, inside haemoglobin and outside storage solution, and accounts for ageing effects by embedding time-dependent c ....A new biomechanical model for understanding aging of stored Red Blood Cells. This project plans to develop a novel modelling framework to accurately represent the biomechanical properties of red blood cells (RBCs) over time under stored conditions. Stored RBCs suffer ageing-related deformability changes which impede RBC functions. The framework aims to integrate models for RBC membrane, inside haemoglobin and outside storage solution, and accounts for ageing effects by embedding time-dependent correlations. It should provide new insights and understanding of the mechanisms of deformability changes of RBCs during stored lifespan. Therefore, it should significantly improve blood storage industry practices in terms of improving RBC storage protocols with preventative ageing strategies.Read moreRead less