Discovery Early Career Researcher Award - Grant ID: DE120101340
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Subversion of innate immune responses by pathogenic Escherichia coli. This project will determine how bacteria that cause diarrhoeal diseases prevent the immune system from signalling efficiently. It will provide important information not only about how the bacteria establish disease, but also provide insight into the host response in the early stages of infection.
Discovery Early Career Researcher Award - Grant ID: DE120101730
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Targeting cell death pathways in parasites. Schistosomiasis is a disease caused by parasitic worms. Due to the potential for drug resistance, new drugs are needed. This project aims to identify the components needed for parasite survival based on a cell death pathway in schistosomes. Neutralising the activities of these proteins should cause parasite death, providing a new treatment strategy.
Discovery Early Career Researcher Award - Grant ID: DE220100403
Funder
Australian Research Council
Funding Amount
$468,582.00
Summary
Defining how gut bacteria regulate metabolism: a role for gut serotonin. This project aims to understand how serotonin-producing cells in the gut interact with gut bacteria (the microbiome), using a combination of cells in culture and live germ-free and genetically modified mice. This project expects to generate new knowledge regarding cellular interactions that underlie important physiological pathways, such as the control of blood glucose and fat storage. The intended outcomes of this project ....Defining how gut bacteria regulate metabolism: a role for gut serotonin. This project aims to understand how serotonin-producing cells in the gut interact with gut bacteria (the microbiome), using a combination of cells in culture and live germ-free and genetically modified mice. This project expects to generate new knowledge regarding cellular interactions that underlie important physiological pathways, such as the control of blood glucose and fat storage. The intended outcomes of this project are to identify how gut bacteria communicate with serotonin-producing cells to regulate metabolism, and whether diet acts via a gut microbiome-serotonin axis to impact physiology. The expected benefit of this project will be to provide a new understanding of highly complex physiological systems that regulate our health.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE120102571
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Visualising living airways: a new x-ray technique to assess Cystic Fibrosis treatments. The ability to non-invasively observe the body's inner functions at high magnification is critical in developing new medical treatments. This project will establish an x-ray technique capable of imaging subtle biological function at high magnification and apply this technique to assessing new treatments for airways affected by Cystic Fibrosis.
Discovery Early Career Researcher Award - Grant ID: DE190100174
Funder
Australian Research Council
Funding Amount
$400,747.00
Summary
Calcium-mediated regulation of stem cell development. This project aims to clarify the role of syndecan-mediated calcium in stem cell development using Caenorhabditis elegans. Stem cells have great potential for regenerative studies. While stem cells cultures are widely used, we do not fully understand how stem cells develop within an organism. This project expects to uncover the mechanisms underpinning calcium regulation by syndecan in stem cells. The expected outcomes include the optimisation ....Calcium-mediated regulation of stem cell development. This project aims to clarify the role of syndecan-mediated calcium in stem cell development using Caenorhabditis elegans. Stem cells have great potential for regenerative studies. While stem cells cultures are widely used, we do not fully understand how stem cells develop within an organism. This project expects to uncover the mechanisms underpinning calcium regulation by syndecan in stem cells. The expected outcomes include the optimisation of C. elegans stem cell methods to screen calcium regulating compounds and the creation of an in vivo calcium sensor. The project should advance knowledge of the role of syndecans in stem cells and provide the first analysis of in vivo calcium kinetics in stem cells.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE130101222
Funder
Australian Research Council
Funding Amount
$371,392.00
Summary
The development of novel magnetic resonance imaging methods to investigate brain structure and function. Magnetic resonance imaging (MRI) is a non-invasive method that has revolutionised neuroscience. The goal of this project is to develop state-of-the-art MRI analysis methods that reveal new information about brain structure and function. These novel neuroimaging tools will be instrumental in furthering our understanding of how the brain works.
Discovery Early Career Researcher Award - Grant ID: DE120100488
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
When should health professionals override parents' decisions about a child's medical treatment? Doctors and nurses sometimes disagree with parents' decisions about the best treatment for a sick child. This project will establish the ethical responsibilities of both parents and health professionals in relation to medical decision-making for children.
Discovery Early Career Researcher Award - Grant ID: DE130100922
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Diamond cybernetics: nanocrystalline diamond for interfacing bionic devices with the human nervous system. Bionic devices will soon be used to treat disorders such as epilepsy, Parkinson's and depression. We will use diamond to create high resolution, permanent electrical connections between devices and the human nervous system. These diamond connections will preserve nerve health and make bionic devices more effective and able to last a lifetime.
Discovery Early Career Researcher Award - Grant ID: DE190101209
Funder
Australian Research Council
Funding Amount
$390,000.00
Summary
Genes underlying enteric neuron subtype differentiation. This project aims to use new RNA-sequencing technology to identify genes important for differentiation of several major enteric neuron subtypes. Proper development and function of the digestive tract is crucial for good health. Gastrointestinal function relies on the co-ordinated activity of neural circuits in the enteric nervous system. This project will advance Australia's knowledge base and research capabilities in the field basic devel ....Genes underlying enteric neuron subtype differentiation. This project aims to use new RNA-sequencing technology to identify genes important for differentiation of several major enteric neuron subtypes. Proper development and function of the digestive tract is crucial for good health. Gastrointestinal function relies on the co-ordinated activity of neural circuits in the enteric nervous system. This project will advance Australia's knowledge base and research capabilities in the field basic developmental neuroscience, by innovative use of Next Generation RNA-sequencing technology to investigate enteric neuron subtype differentiation. The project outcomes include the generation of neuron subtype specific progenitors from naïve stem cells, which will in the longer term have significant health benefits, as gastrointestinal dysfunction is a large health and economic burden in Australia.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE160100900
Funder
Australian Research Council
Funding Amount
$366,000.00
Summary
Smart aptamer-guided nanoexosome as a novel biotechnology platform. This project aims to develop guided novel nanomaterials as a new biotechnological platform for in vivo targeted delivery of Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) for gene editing. By systematically engineering the surface properties of natural nanovesicles known as exosomes, a novel nanotechnology platform should be established. The guided nano biotechnological platform should not only enable targete ....Smart aptamer-guided nanoexosome as a novel biotechnology platform. This project aims to develop guided novel nanomaterials as a new biotechnological platform for in vivo targeted delivery of Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) for gene editing. By systematically engineering the surface properties of natural nanovesicles known as exosomes, a novel nanotechnology platform should be established. The guided nano biotechnological platform should not only enable targeted in vivo precision gene editing via CRISPR but also specific delivery of gene editing machinery across the blood brain barrier for better exploration of fundamental biology of the brain.Read moreRead less