Discovery Early Career Researcher Award - Grant ID: DE220100311
Funder
Australian Research Council
Funding Amount
$383,982.00
Summary
Shining nanoparticles for single microRNA detection in microfluidics. This project aims to extensively study the interface between nanoparticles and nucleic acids. It sets out to produce a novel ultrasensitive high-performance biosensing platform that will combine luminescent nanoparticles with microfluidics in a digital assay. This portable platform will detect biological fingerprints, or microRNAs, at a single-molecule level, delivering unprecedented levels of sensitivity and specificity. The ....Shining nanoparticles for single microRNA detection in microfluidics. This project aims to extensively study the interface between nanoparticles and nucleic acids. It sets out to produce a novel ultrasensitive high-performance biosensing platform that will combine luminescent nanoparticles with microfluidics in a digital assay. This portable platform will detect biological fingerprints, or microRNAs, at a single-molecule level, delivering unprecedented levels of sensitivity and specificity. The multiplexed platform has the potential to benefit the biomedical research of microRNAs and opens up a genuine commercialisation potential for portable biosensing of nucleic acids.Read moreRead less
A novel scintillating optical fibre array for cancer imaging and therapy. This project aims to realise a next-generation detector technology that delivers the first fully integrated solution to the X-ray imaging and dose measurement needs of cancer radiation therapy. It is planned that this will be achieved by optimising an experimental prototype device employing a scintillating optical fibre array to generate an optical signal that preserves a tissue-equivalent detector response. The acquired d ....A novel scintillating optical fibre array for cancer imaging and therapy. This project aims to realise a next-generation detector technology that delivers the first fully integrated solution to the X-ray imaging and dose measurement needs of cancer radiation therapy. It is planned that this will be achieved by optimising an experimental prototype device employing a scintillating optical fibre array to generate an optical signal that preserves a tissue-equivalent detector response. The acquired digital image can thus be used to simultaneously verify geometric accuracy (correct patient positioning) and dosimetric accuracy (correct dose distribution). This is not currently possible with existing X-ray detector technology and offers an improvement in treatment accuracy.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE180100043
Funder
Australian Research Council
Funding Amount
$435,279.00
Summary
High-throughput portable and wearable device fabrication facility. This project aims to establish a fabrication and characterisation facility for high-throughput production of portable, wearable and stretchable biomedical devices to accelerate the design–fabrication–evaluation process and save ‘trial-and-error’ costs during optimisation turnaround. It will apply computer-aided design for the programmable synthesis of hybrid materials for high-throughput screening of disease biomarkers, and super ....High-throughput portable and wearable device fabrication facility. This project aims to establish a fabrication and characterisation facility for high-throughput production of portable, wearable and stretchable biomedical devices to accelerate the design–fabrication–evaluation process and save ‘trial-and-error’ costs during optimisation turnaround. It will apply computer-aided design for the programmable synthesis of hybrid materials for high-throughput screening of disease biomarkers, and super-solution imaging of single molecules in live cells. This facility will provide capability for researchers pursuing industry transformation and other initiatives in the development of advanced materials, biomolecular sciences, nanotechnology, photonics and device engineering.Read moreRead less
Development of an electrode for stimulation of a transplanted neosphincter. This project aims to develop a novel electrode as an integral component of a new treatment for severe stress urinary incontinence. Treatments for severe stress urinary incontinence are associated with complications and are not completely effective. The new electrode is designed to be activated by an implanted stimulator to control an innervated smooth muscle graft (the neosphincter) to regulate the flow of urine from the ....Development of an electrode for stimulation of a transplanted neosphincter. This project aims to develop a novel electrode as an integral component of a new treatment for severe stress urinary incontinence. Treatments for severe stress urinary incontinence are associated with complications and are not completely effective. The new electrode is designed to be activated by an implanted stimulator to control an innervated smooth muscle graft (the neosphincter) to regulate the flow of urine from the bladder. Project research into the design of the electrode will focus on providing safe, effective and efficient stimulation of the neosphincter, while ensuring minimal damage to the surrounding tissues and affording straightforward implantation at surgery.Read moreRead less
Development of an electrode assembly for the stimulation of a transplanted innervated smooth muscle sphincter. This project will design and assess a number of different electrode designs for use in a medical device being developed for the treatment of severe stress urinary incontinence. The project will identify an optimal electrode design, which will be used in future clinical trials of the device.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE150100177
Funder
Australian Research Council
Funding Amount
$440,000.00
Summary
National Live Cell Scanning Platform for Nanoparticle Tracking. National live cell scanning platform for nanoparticle tracking: The aim of the project is to establish a multi-disciplinary, multi-user, self-correlated scanning facility to reach a new level of temporal and spatial precision for real-time tracking and quantification of biomolecules and nanoparticles within large populations of living cells. The facility will consist of a live-cell spinning-disc confocal microscope, a correlated bio ....National Live Cell Scanning Platform for Nanoparticle Tracking. National live cell scanning platform for nanoparticle tracking: The aim of the project is to establish a multi-disciplinary, multi-user, self-correlated scanning facility to reach a new level of temporal and spatial precision for real-time tracking and quantification of biomolecules and nanoparticles within large populations of living cells. The facility will consist of a live-cell spinning-disc confocal microscope, a correlated biological atomic force microscope, and remote access facilities. It is expected that with superior optical characterisation and mechanical manipulation, the automated orthogonal scanning facility will open new avenues to reveal unprecedented information from biological and pathological processes. The collaborative facility will support world-class researchers in the multi-disciplinary areas of physical, material and life sciences, placing Australia at the forefront of nanoscale biophotonics.Read moreRead less
Bacterial detection and infection control using tethered membranes. This project will develop a rapid diagnostic tool to detect live bacteria, which will subsequently reduce risk of infection, increase efficiencies in patient care and hospital management, and produce savings in health care budgets. It also has the potential to save lives through addressing the serious and growing problem of antibiotic resistance.
Discovery Early Career Researcher Award - Grant ID: DE120102556
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
The influence of crosstalk between protein post-translational modifications on the propagation of molecular signals. The ability of a cell to respond appropriately to its surroundings is a result of interactions between proteins and chemical modifiers termed post-translational modifications (PTM). This project will show how PTM interactions (competition/ cooperation) influence cellular outcomes in response to changes in the environment.
Diamond glass: An all-carbon technology for neural networks and biosensing. This project aims to use plasma deposition to synthesise diamond glass with the highest purity and the most diamond-like character so that it meets the strict requirements for emerging device applications. The extreme properties of diamond glass arise from the diamond-like bonding of the majority of its atoms. This amorphous, wide bandgap semiconductor is also the hardest known glass. The maximum diamond-like content pos ....Diamond glass: An all-carbon technology for neural networks and biosensing. This project aims to use plasma deposition to synthesise diamond glass with the highest purity and the most diamond-like character so that it meets the strict requirements for emerging device applications. The extreme properties of diamond glass arise from the diamond-like bonding of the majority of its atoms. This amorphous, wide bandgap semiconductor is also the hardest known glass. The maximum diamond-like content possible in diamond glass coatings is unknown, so determining its ultimate performance is difficult. Expected applications include medical diagnostics, non-volatile memories and programmable chips.Read moreRead less
Novel technologies for motion-compensated simultaneous Magnetic Resonance Imaging (MRI) and Positron Emission Tomography (PET) imaging. The aim of this work is to develop motion tracking and motion correction techniques for an emerging hybrid imaging technology, MR-PET. The MR-PET scanner simultaneously acquires structural MR images and functional PET images. The work will provide clearer images without the effects of motion blur for both research and clinical applications.