Placental nutrient transport shows how complex traits evolve. This project aims to use amino acid transport in the vertebrate placenta as a model to demonstrate how genes are recruited and modified to produce a major organ. Using an innovative combination of a new technology, selected reaction monitoring, and transcriptomic and molecular approaches, plus carefully selected Australian species pairs, this project will study the evolution of a complex trait (placental amino acid transport). The pr ....Placental nutrient transport shows how complex traits evolve. This project aims to use amino acid transport in the vertebrate placenta as a model to demonstrate how genes are recruited and modified to produce a major organ. Using an innovative combination of a new technology, selected reaction monitoring, and transcriptomic and molecular approaches, plus carefully selected Australian species pairs, this project will study the evolution of a complex trait (placental amino acid transport). The project will provide fundamental advances in our knowledge of the nutrient transport during pregnancy that is required to produce a healthy baby.Read moreRead less
Lively reproduction: do common molecules underlie all vertebrate live birth? Most animals lay eggs, but some (most mammals, including humans and some reptiles) give birth to live young. This project will reveal the molecules underlying the evolution of live birth and fundamental processes of early pregnancy, which potentially will lead to future developments in reproductive science.
Dark canaries: new multidisciplinary understanding about the origins, radiation and response to environmental change of southern hemisphere bats. This project will overhaul global understanding of the origins of bats, their flight patterns and the role of echolocation in resource partitioning in an environmentally changing Australia. It will also provide information vital for conservation and novel biomimetic understanding of the modulation of ultrasound for medical and engineering purposes.
The link between the angiogenesis of live birth and cancer: a lizard model. The possible link between live birth and cancer will be tested in this project. Lizards that express a growth factor that helps the growth of human cancer tumours will be studied to determine the action of the factor in a whole animal and in human cancer cells.
The Social Life of Death. This project aims to investigate experiences of death, dying and bereavement amidst rapid social, economic and political transformation. In the wake of COVID19, and as Australia’s anticipated ‘death boom’ approaches, how to foster good deaths has never been more uncertain, nor more urgent. Drawing on innovative methods and socio-cultural theory, and working in partnership with families and communities, this project aims to generate new knowledge to better inform and imp ....The Social Life of Death. This project aims to investigate experiences of death, dying and bereavement amidst rapid social, economic and political transformation. In the wake of COVID19, and as Australia’s anticipated ‘death boom’ approaches, how to foster good deaths has never been more uncertain, nor more urgent. Drawing on innovative methods and socio-cultural theory, and working in partnership with families and communities, this project aims to generate new knowledge to better inform and improve policy and spark cultural renewal around the end of life. Expected outcomes include setting the international benchmark for novel scholarly understandings of death, dying and bereavement, and centring community voices in addressing contemporary challenges to dying well.
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Molecular microscopy: protein and membrane dynamics in resting and activated T cells. The aim of this research, to understand the molecular organization and dynamics of the plasma membrane that underlie the signal transduction events, is at the very heart of understanding cell communication. T cell recognition and activation initiates an adaptive immune response to invading pathogens and structurally altered proteins that can be found in cancers. By providing functional insights into the molecul ....Molecular microscopy: protein and membrane dynamics in resting and activated T cells. The aim of this research, to understand the molecular organization and dynamics of the plasma membrane that underlie the signal transduction events, is at the very heart of understanding cell communication. T cell recognition and activation initiates an adaptive immune response to invading pathogens and structurally altered proteins that can be found in cancers. By providing functional insights into the molecular mechanism of T cell activation, we will not only provide fundamental knowledge of receptor signalling but also specific details of T cell receptort triggering that may lead to the development of new therapeutic strategies to control T cell activation.Read moreRead less
Optimising Removal of Proteinaceous Foulants from Membranes. Removal of proteinacous foulants from membrane systems imposes both significant economic costs in terms of chemical usage as well as significant environmental costs in terms of water usage and production of effluents from the cleaning and rinsing waters. The outcome of this project should allow us to develop methods for the prediction and optimisation of membrane cleaning performance of relevance to major Australian industries includin ....Optimising Removal of Proteinaceous Foulants from Membranes. Removal of proteinacous foulants from membrane systems imposes both significant economic costs in terms of chemical usage as well as significant environmental costs in terms of water usage and production of effluents from the cleaning and rinsing waters. The outcome of this project should allow us to develop methods for the prediction and optimisation of membrane cleaning performance of relevance to major Australian industries including the dairy, food processing and water and waste water treatment industries.Read moreRead less
A unified model of amino acid homeostasis. This project aims to develop a unified model of amino acid homeostasis in mammalian cells and apply it to brain cells. The model will be underpinned by a mathematical algorithm that allows predicting amino acid levels in the cytosol based on fundamental parameters such as transport and metabolism. This project should provide the significant benefit of enabling the prediction of essential functions such as cell growth and survival.
An International Comparison of Corporate Financial Policy. Our research contributes to the finance discipline, corporate decision making and public policy. Existing empirical literature provides managers with insights on the impact of firm characteristics on corporate financial decisions. However, beyond suggesting that well-functioning banks, equity and bond markets are an integral part of corporate financing, no insight is provided as to the role played by the public policy, legal structures a ....An International Comparison of Corporate Financial Policy. Our research contributes to the finance discipline, corporate decision making and public policy. Existing empirical literature provides managers with insights on the impact of firm characteristics on corporate financial decisions. However, beyond suggesting that well-functioning banks, equity and bond markets are an integral part of corporate financing, no insight is provided as to the role played by the public policy, legal structures and the suppliers of capital. In a market such as Australia, where superannuation is a large and increasing part of corporate funding, this is a glaring omission. This study seeks to examine the impact of public policy, legal and institutional structures on these financial choices.Read moreRead less
The Professions, Human Rights, and the State: law and medicine in the transition from repression to democracy. This study contributes to an ?anthropology of democracy? examining the processes of political transition beyond the state. It investigates the role of the health and legal professions with regard to human rights abuses occurring during and after state repression taking the cases of Argentina and South Africa. It explores the way the legal and health professions extend human rights thro ....The Professions, Human Rights, and the State: law and medicine in the transition from repression to democracy. This study contributes to an ?anthropology of democracy? examining the processes of political transition beyond the state. It investigates the role of the health and legal professions with regard to human rights abuses occurring during and after state repression taking the cases of Argentina and South Africa. It explores the way the legal and health professions extend human rights through their respective ethical responsibilities thereby enhancing citizenship in the post-transition period. It will provide important insights into the roles professions play in mediating between civil society and the state in a transnational context.Read moreRead less