Structural And Functional Analysis Of A Cancer-linked Co-regulator Complex
Funder
National Health and Medical Research Council
Funding Amount
$729,571.00
Summary
We seek to understand the mechanisms by which genes are switched on and off throughout our lifetime. A number of multi-component protein machines are involved in this process but their make-up and mechanism of action is not understood. We will investigate the structure and function of one of these machines that has been strongly linked to cancer.
Discovery And Development Of Better Pain Treatments
Funder
National Health and Medical Research Council
Funding Amount
$9,613,850.00
Summary
Many forms of pain remain poorly treated, leading to significant quality of life and economic losses. This Program grant will discover and characterise new peptides from cone snails and spiders that modulate specific channels in nerves that are critical to the transmission of pain signals to the brain. Using advanced chemical and structural approaches, promising leads will be optimised for potency and stability and evaluated in disease and pathway-specific models of pain to establish their clini ....Many forms of pain remain poorly treated, leading to significant quality of life and economic losses. This Program grant will discover and characterise new peptides from cone snails and spiders that modulate specific channels in nerves that are critical to the transmission of pain signals to the brain. Using advanced chemical and structural approaches, promising leads will be optimised for potency and stability and evaluated in disease and pathway-specific models of pain to establish their clinical potential.Read moreRead less
Characterisation and Treatment of Reverse Osmosis Concentrates from Water Recycling Applications. Concentrates from reverse osmosis (RO) pose a considerable threat to both the environment but also the successful implementation of reverse osmosis as a technology. Naturally, the concentrate contains everything that the RO retains and hence contaminants such as viruses, organics such as pharmaceutically active compounds and hormones as well as nutrients and salinity. Treatment of such waste streams ....Characterisation and Treatment of Reverse Osmosis Concentrates from Water Recycling Applications. Concentrates from reverse osmosis (RO) pose a considerable threat to both the environment but also the successful implementation of reverse osmosis as a technology. Naturally, the concentrate contains everything that the RO retains and hence contaminants such as viruses, organics such as pharmaceutically active compounds and hormones as well as nutrients and salinity. Treatment of such waste streams will enhance the health of receiving water bodies and reduce the risk of increased build up of contaminants if wastes are recycled into wastewater treatment plants. New ways to treat such contaminants will be explored, the efficiency and cost evaluated in the broader water cycle and sustainability framework.Read moreRead less
Bridging the gap on locational disadvantage: Impact of community-identified interventions on social capital, psychosocial and socioeconomic outcomes. Interventions to combat locational disadvantage are vital given the pervasiveness and long-term consequences for youth and communities. This research will offer important educational and socio-economic benefits by enriching the psychosocial adjustment and life potential of young Australians and the capacity of schools in locationally disadvantaged ....Bridging the gap on locational disadvantage: Impact of community-identified interventions on social capital, psychosocial and socioeconomic outcomes. Interventions to combat locational disadvantage are vital given the pervasiveness and long-term consequences for youth and communities. This research will offer important educational and socio-economic benefits by enriching the psychosocial adjustment and life potential of young Australians and the capacity of schools in locationally disadvantaged communities. Effective research and community-identified social capital and psychosocial interventions will enhance pro-social behaviours, health, psychosocial adjustment, and school and community engagement. This will build capacity at community, school, and individual levelsand contribute to national socioeconomic wellbeing.Read moreRead less
The molecular basis of cold adaptation: an integrated genomic and proteomic study of Antarctic archaea. The project enables Australia to remain a world leader in extremophiles, cold adaptation and Antarctic biology, strengthening the reputation Australian scientists have in scientific programs of global significance and fostering the interests of the international community in sciences ranging from bioprospecting to the search for extraterrestrial life. National benefit is directly derived from ....The molecular basis of cold adaptation: an integrated genomic and proteomic study of Antarctic archaea. The project enables Australia to remain a world leader in extremophiles, cold adaptation and Antarctic biology, strengthening the reputation Australian scientists have in scientific programs of global significance and fostering the interests of the international community in sciences ranging from bioprospecting to the search for extraterrestrial life. National benefit is directly derived from technological innovation and training local scientists in modern biology of environmental microorganisms. The Antarctic microorganisms provide unique compounds, enzymes and molecules for biotechnology and industry. Insight will be gained into the critical role that methanogens play in the global carbon cycle and global warming.Read moreRead less
A community-based approach to the problem of underage drinking. This project will aim to reduce the frequency and amount of alcohol consumption, and alcohol-related harms, among young people aged 12-17 years by addressing social norms regarding underage alcohol consumption. Using a multi-component intervention it will engage the Illawarra community in strategies to encourage and empower young people not to drink.
Emotional responses to comparisons in romantic relationships: implications for relationship wellbeing. This project will identify the nature of the emotions that stem from comparisons between romantic partners. It will reveal how these emotions in turn impact relationship dynamics and ultimately, relationship wellbeing. This research will provide important insights into the underlying processes that make some relationships thrive and others fail.
The role of implicit identity and implicit beliefs in recovery from mental illness. Although effective treatments have been developed for many mental disorders, some people still fail to recover when others with a similar psychological profile respond well to therapy. The proposed research addresses this conundrum by examining the role of unconscious identification with mental illnesses and the role it plays in recovery.
Discovery Early Career Researcher Award - Grant ID: DE150101687
Funder
Australian Research Council
Funding Amount
$340,000.00
Summary
Nanostructure Tailoring of Inorganic Membranes by Rapid Thermal Processing. This project aims to produce inorganic membranes with desired nanostructures using a Rapid Thermal Processing (RTP) technique for gas separation applications. The key concept of the research is that the RTP will be able to achieve thin-film membrane layer with a finer microstructure and pore size control without heat stress-induced cracking. RTP aims to deliver superior membrane performance with less than 10 per cent of ....Nanostructure Tailoring of Inorganic Membranes by Rapid Thermal Processing. This project aims to produce inorganic membranes with desired nanostructures using a Rapid Thermal Processing (RTP) technique for gas separation applications. The key concept of the research is that the RTP will be able to achieve thin-film membrane layer with a finer microstructure and pore size control without heat stress-induced cracking. RTP aims to deliver superior membrane performance with less than 10 per cent of the fabrication time compared to normal slow calcination. The outcomes of this new technology aims to make inorganic membranes a commercial reality and maximize the membrane manufacturing capability and productivity of petrochemcial, chemical and clean coal/energy industries.Read moreRead less
Youth services in remote communities. This project aims to improve outcomes for high-risk youth in remote communities in Australia and Canada. It will establish a transdisciplinary research network comprising researchers and services experienced in delivering programmes to high-risk youth; develop a universal intervention definition, and a useful, scientifically rigorous evaluation framework; and integrate the intervention and evaluation framework into participating services’ routine service del ....Youth services in remote communities. This project aims to improve outcomes for high-risk youth in remote communities in Australia and Canada. It will establish a transdisciplinary research network comprising researchers and services experienced in delivering programmes to high-risk youth; develop a universal intervention definition, and a useful, scientifically rigorous evaluation framework; and integrate the intervention and evaluation framework into participating services’ routine service delivery. This project expects to increase the number and quality of services available for high-risk youth, improve their social, health and economic outcomes, and generate positive economic benefit for their communities.Read moreRead less