Modeling Human Actin Related Protein 2/3 Complex Subunit 1B (ARPC1B) Deficiency In Mice
Funder
National Health and Medical Research Council
Funding Amount
$755,005.00
Summary
The actin cytoskeleton forms the structure that not only keeps cells in their normal shape but is also essential for the movement of cells and for interaction between cells. We have recently identified the first patients with an immunodeficiency caused by a defect in a gene called ARPC1B, which plays a crucial role in the regulation of actin. Through the investigation of novel mouse models we will elucidate the pathomechanism underlying the disease of these patients.
The Tasmanian Healthy Brain Project: A Longitudinal Intervention Study To Reduce The Risk Of Ageing-related Cognitive Decline And Dementia
Funder
National Health and Medical Research Council
Funding Amount
$878,792.00
Summary
It has been proposed that engagement in purposeful complex mental stimulation provides protection against dementia. The Tasmanian Healthy Brain Project (THBP) is a unique, large-scale prospective trial that examines whether university-level study in older adult population reduces ageing-related cognitive decline and risk of dementia. This project will also examine how an individual’s genetic profile may influence the potential benefits of complex mental stimulation as well as risk of dementia.
Ocular Motility In Autism And Asperger S Disorder: Dissociation Of Motor Deficits.
Funder
National Health and Medical Research Council
Funding Amount
$131,235.00
Summary
We will use ocular motor technology to investigate motor dysfunction in autism and Asperger's disorder, to advance our understanding of the neurobiological bases of these disorders. This will help clarify whether neural networks are differentially disrupted in these disorders, as our previous clinical research suggests. This dissociation and the subsequent development of an ocular motor clincal screen may improve diagnosis, and potentially treatment, of these devastating conditions.
Motor Functioning In Autism And Asperger's Disorder: Furthering Current Neurobehavioural And Clinical Definitions
Funder
National Health and Medical Research Council
Funding Amount
$354,932.00
Summary
While it is well known that autism and Asperger's disorder are associated with social, communicative, and behavioural symptoms, it is less well known that affected individuals also have considerable movement and coordination difficulties. For example, these children often have problems with hand writing, walking, hopping, skipping, catching, and running. These skills are very important for success at school; for example, if children are unable to participate in school sports they often feel isol ....While it is well known that autism and Asperger's disorder are associated with social, communicative, and behavioural symptoms, it is less well known that affected individuals also have considerable movement and coordination difficulties. For example, these children often have problems with hand writing, walking, hopping, skipping, catching, and running. These skills are very important for success at school; for example, if children are unable to participate in school sports they often feel isolated and rejected from the peer group. Also, hand writing problems have a significant impact on children's academic performance. Our previous research has suggested that there may be particular patterns of motor problems that characterise individuals with autism and Asperger's disorder. Our proposed research aims to use the kinds of 3D motion analysis technology used in the movie industry to capture exactly how people affected by these conditions move and respond to the environment. This study will enable us to highlight particular parts of the brain-motor circuitry that are affected by these disorders and will also enable us to more clearly distinguish how autism is different from Asperger's disorder. Ultimately, it is hoped that our motor investigations will lead to improved assessment and interventions for these disorders.Read moreRead less
Individual Differences in Orientations to Risk and Uncertainty. The main goal of this research project is to extend and integrate three individual-differences approaches to predicting and explaining human judgement and decision making (JDM) and risk-taking behaviours (RTB) under uncertainty: Cognitive-capacity, preferences and dispositions, and dual cognitive process approaches. It will achieve this by studying the joint impact of cognitive style, capacities, and RTB/JDM dispositions on performa ....Individual Differences in Orientations to Risk and Uncertainty. The main goal of this research project is to extend and integrate three individual-differences approaches to predicting and explaining human judgement and decision making (JDM) and risk-taking behaviours (RTB) under uncertainty: Cognitive-capacity, preferences and dispositions, and dual cognitive process approaches. It will achieve this by studying the joint impact of cognitive style, capacities, and RTB/JDM dispositions on performance in appropriate JDM tasks. JDM and RTB are at the root of managing uncertainty, human adaptiveness and rationality. This project will also extend our knowledge of gender differences in JDM and RTB, and lay foundations for systematic cross-cultural studies on this topic.Read moreRead less
Programming Paradigms, Tools and Algorithms for Electronic Structure Calculations on Clusters of Non-Uniform Memory Access Parallel Processors. In recent years Australian academia has invested heavily in high performance computing systems. A significant fraction of these resources are devoted to performing computational chemistry studies, such as those used in drug design. This project links Australian researchers with the company responsible for a particularly widely used computational chemistr ....Programming Paradigms, Tools and Algorithms for Electronic Structure Calculations on Clusters of Non-Uniform Memory Access Parallel Processors. In recent years Australian academia has invested heavily in high performance computing systems. A significant fraction of these resources are devoted to performing computational chemistry studies, such as those used in drug design. This project links Australian researchers with the company responsible for a particularly widely used computational chemistry application package, and also with a major international computer company. Our aim is to substantially improve the performance of this code on cluster based compute systems. This, as well as our generic performance evaluation tools, would be of substantial benefit to the Australian research community. The project will forge links with researchers in Singapore, Japan and the USA.Read moreRead less
Face recognition: Properties and origins of whole-face processing. Humans identify other individuals almost entirely by their faces. Correspondingly, research has demonstrated a "special" style of cognitive processing that is unique to faces (at least in ordinary adults). The present project will address two major theoretical issues: (1) the exact nature of the special processing for faces, and (2) the extent to which it is innate, or learned. New progress in understanding these issues will be m ....Face recognition: Properties and origins of whole-face processing. Humans identify other individuals almost entirely by their faces. Correspondingly, research has demonstrated a "special" style of cognitive processing that is unique to faces (at least in ordinary adults). The present project will address two major theoretical issues: (1) the exact nature of the special processing for faces, and (2) the extent to which it is innate, or learned. New progress in understanding these issues will be made using a series of novel experimental techniques. These techniques isolate the specific contribution of the face recognition system, independent of contributions from object recognition, and from early visual processing.Read moreRead less
Special cognitive processing for faces: Expertise effects, and links to neural mechanisms. Humans identify other individuals primarily by their faces. Evidence from cognitive psychology indicates a special 'whole-face' (as opposed to part-based) style of processing for upright faces. This project will provide new insights into two long-standing issues about the origin of special face processing: (1) whether it derives from generic expert recognition processes or has some face-specific innate co ....Special cognitive processing for faces: Expertise effects, and links to neural mechanisms. Humans identify other individuals primarily by their faces. Evidence from cognitive psychology indicates a special 'whole-face' (as opposed to part-based) style of processing for upright faces. This project will provide new insights into two long-standing issues about the origin of special face processing: (1) whether it derives from generic expert recognition processes or has some face-specific innate component; and (2) the extent to which it can be distinguished from part-based processing at the neural level using both functional brain imaging (fMRI) and adaptation to distorted faces.Read moreRead less
Prevalence report by the Australian Advisory Board on Autism Spectrum Disorders (ASD) estimated that 1 child in every 160 children in the 6-12 year-old age group is affected by ASD. There is no cure for ASD and the causes are not understood. We propose that sex hormones may play a role in the development of these disorders. We will test this hypothesis using knockout and transgenic mouse models which have social interaction deficits and brain structure reminiscent of these disorders.
Programming Paradigms, Tools and Algorithms for the Spectral Solution of the Electronic Schroedinger Equation on Non-Uniform Memory Parallel Processors. We propose to develop software tools and methods that are appropriate for current and future generations of large scale shared memory computer systems. Our purpose is to enable a more productive utilization of these architectures for scientific computation. We will focus on algorithms for solving differential equations appropriate to quantum che ....Programming Paradigms, Tools and Algorithms for the Spectral Solution of the Electronic Schroedinger Equation on Non-Uniform Memory Parallel Processors. We propose to develop software tools and methods that are appropriate for current and future generations of large scale shared memory computer systems. Our purpose is to enable a more productive utilization of these architectures for scientific computation. We will focus on algorithms for solving differential equations appropriate to quantum chemistry. In particular an exciting new class of methods whose computational cost scales linearly with system size. Our goal is to develop scalable parallel implementations of these methods. If realized this will revolutionize computation, enabling first principles calculations on truly nanoscale systems, such as enzymes and molecular electronic devices.Read moreRead less