Studies Of The Effects Of Asymmetric Hearing Loss On The Brain
Funder
National Health and Medical Research Council
Funding Amount
$920,076.00
Summary
Hearing loss impairs the normal development and maintenance of auditory pathways. Irreversible pathologies persist when hearing is not restored in a timely manner. While cochlear implantation is the accepted treatment for profound sensorineural hearing loss, there is significant variability in outcomes. Some of this variability is linked to the degree of hearing asymmetry. Thus, we propose to study brain changes in the auditory system that accompany asymmetric hearing impairment.
Intrinsic Hearing Protection Mechanisms: A Pathway To Prevention Of Noise-induced Hearing Loss
Funder
National Health and Medical Research Council
Funding Amount
$625,900.00
Summary
Noise-induced hearing loss (NIHL) is a significant contributor to the total burden of disease. We recently determined that when the ear is exposed to sustained noise, the cochlea is protected from damage by activation of a specific (P2X2) receptor, evident as reversible hearing adaptation. This study will determine the downstream signalling from this receptor. This will support assessment of vulnerability to NIHL and contribute to development of hearing therapeutics.
Hearing Protection Conferred By P2X2 Receptor Signaling In The Cochlea
Funder
National Health and Medical Research Council
Funding Amount
$580,019.00
Summary
Hearing loss from noise damage and ageing is the principal sensory disability in our society. This project will determine the contribution of the P2X2 receptor to protection from noise-induced hearing loss. We have found that P2X2 knockout mice have minimal temporary threshold shift. We will investigate the physiological basis for this and determine why this mouse model has greater hearing loss with intense sound and faster age-related hearing loss compared with wildtype controls.
Gene Therapy For Preventing Progressive Sensorineural Hearing Loss And Restoring Hearing
Funder
National Health and Medical Research Council
Funding Amount
$549,848.00
Summary
This proposal aims to study the clinical feasibility and safety of gene therapy in the guinea pig cochlea for preventing progressive hearing loss and restoring hearing. Two cell survival genes (GDNF and BDNF) will be studied for preserving sensory (hair) cells and hearing nerves, while a gene called Atoh1 will be investigated for its ability to regenerate new hair cells and restore hearing after the onset of progressive hearing loss.
A Study Of The Role Of Voltage-gated Potassium Channels In The Process Of Phototransduction, In The Setting Of Photoreceptor Sensitivity Levels And Response Times, And In The Progression Of A Distinctive Form Of Inherited Retinal Dystrophy
Funder
National Health and Medical Research Council
Funding Amount
$360,371.00
Summary
Inherited retinal disease is a major cause of blindness but the genetic basis is extremely heterogeneous. One such disorder, cone dystrophy with supernormal rod ERG, arises from mutations in KCNV2 that encodes a potassium voltage-gated channel protein. The objective of the project is to use animal models of the disease to determine the role of this channel protein in normal visual function and to assess the impact of loss of function on retinal development and function.
Cochlear Type II Neurons In Contralateral Suppression
Funder
National Health and Medical Research Council
Funding Amount
$459,434.00
Summary
Sound in one ear affects hearing in the other ear. This contralateral suppression is important for hearing attention and protection from noise damage. We will test the hypothesis that cochlear type II sensory neurons provide the sensory input for this process using models where neuronal development is altered, or the neurons are removed. The study addresses hearing disability in society, facilitating cochlear prosthesis development and the understanding of hearing loss.
Organization Of Descending Auditory Projections From Inferior Colliculus To Cochlear Nucleus
Funder
National Health and Medical Research Council
Funding Amount
$473,121.00
Summary
Sensory information gains awareness by ascending brain pathways to reach consciousness. Descending projections, however, have grown in importance because of implications for feedback management of ascending signals. Studies of these pathways will provide insight into auditory processing with respect to selective volume control, calibration adjustments between the two ears, and the extraction of signals from background noise. The data could lead to new strategies for treating hearing disorders.
Functional Interactions Between Primate Cortical Areas In Tasks Involving Attention And Short-term Memory
Funder
National Health and Medical Research Council
Funding Amount
$267,280.00
Summary
To navigate and operate in the cluttered and dynamic sensory world around us, our brains need to be able to attend to specific objects or features in the environment, identify them and also know where they exist at any one instant of time, prior to performing the appropriate action. The attention, memory, decision and motor components involved in this process possibly involve a variety of cortical areas and neuronal operations. The special primate preparation we have developed permits us to eluc ....To navigate and operate in the cluttered and dynamic sensory world around us, our brains need to be able to attend to specific objects or features in the environment, identify them and also know where they exist at any one instant of time, prior to performing the appropriate action. The attention, memory, decision and motor components involved in this process possibly involve a variety of cortical areas and neuronal operations. The special primate preparation we have developed permits us to elucidate at a neuronal level many of these brain mechanisms. By recording neuronal activities in two different cortical areas simultaneously as the monkey performs a memory task that he has been trained on, we will test the following ideas: (1) A cortical region in the dorsal, parietal stream directs spatial attention by gating other visual areas to process only a selected region of the visual world (2) A region in the ventral, temporal stream directs attention to specific features in the visual world by gating earlier cortical areas (3) The parietal cortical areas that mediate intention for action hold the relevant information in working memory till it is forwarded to the more anterior premotor areas. These experiments have the potential to reveal the basic neuronal scheme that underpins functions such as attention, visual recognition and memory, which are impaired in many neurological disorders.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE180100433
Funder
Australian Research Council
Funding Amount
$365,058.00
Summary
Cortical layer specific functional imaging of the human brain. This project aims to record layer specific cortical activity in humans by leveraging ultra-high field magnetic resonance imaging. It expects to yield robust techniques for the general analysis of neuroimaging-based, layer-specific measurements. This project will progress the fields of cognitive neuroscience and neuroimaging as well as bring the field of neuroimaging closer to that of neurophysiology and thus facilitate collaboration ....Cortical layer specific functional imaging of the human brain. This project aims to record layer specific cortical activity in humans by leveraging ultra-high field magnetic resonance imaging. It expects to yield robust techniques for the general analysis of neuroimaging-based, layer-specific measurements. This project will progress the fields of cognitive neuroscience and neuroimaging as well as bring the field of neuroimaging closer to that of neurophysiology and thus facilitate collaboration among researchers.Read moreRead less
Mobile computation in human perception and feature binding. Perception is so complex that still we cannot give computers more than a fraction of the human ability to perceive things. Experiments with humans can unravel the computations that underlie human abilities. Here we focus on distinguishing between perceptual mechanisms that analyze information from only patches of the visual world and those that combine information from across the visual field as an object moves across it. Results should ....Mobile computation in human perception and feature binding. Perception is so complex that still we cannot give computers more than a fraction of the human ability to perceive things. Experiments with humans can unravel the computations that underlie human abilities. Here we focus on distinguishing between perceptual mechanisms that analyze information from only patches of the visual world and those that combine information from across the visual field as an object moves across it. Results should also help to understand the general issue of how the brain combines information from different groups of neurons. Australian understanding of brains should be advanced, benefiting neuroscience, medicine, and eventually computer science.Read moreRead less