Mechanisms of fear learning and extinction in the mammalian brain. The brain is a remarkable machine that coordinates all aspects of our daily lives including the storage and retrieval of memories. Given that many age-related degenerative disorders are associated with marked changes in learning and memory it also has implications for Australia's National Research Priority 2 "Ageing well and ageing productively". This research aims to discover the basic mechanisms that underlie memory storage an ....Mechanisms of fear learning and extinction in the mammalian brain. The brain is a remarkable machine that coordinates all aspects of our daily lives including the storage and retrieval of memories. Given that many age-related degenerative disorders are associated with marked changes in learning and memory it also has implications for Australia's National Research Priority 2 "Ageing well and ageing productively". This research aims to discover the basic mechanisms that underlie memory storage and how these are modulated in an emotional context. It will also shed light on states such as anxiety, depression and post-traumatic stress, enhancing our ability to identify new therapeutic targets for such disorders.Read moreRead less
Single and dual process models of recognition memory: Reconciliation of behavioural, electrophysiological, and neuroimaging data. Advanced brain scanning technologies are increasingly used to study human memory. As well as being important for our basic understanding of memory, they also tell us how memory is affected by normal development, ageing, disease, and injury. Unfortunately, because these technologies are so new, a gap has opened up between our psychological understanding of memory and t ....Single and dual process models of recognition memory: Reconciliation of behavioural, electrophysiological, and neuroimaging data. Advanced brain scanning technologies are increasingly used to study human memory. As well as being important for our basic understanding of memory, they also tell us how memory is affected by normal development, ageing, disease, and injury. Unfortunately, because these technologies are so new, a gap has opened up between our psychological understanding of memory and the physiological events measured by the scanning technologies. This has created a problem for how we should interpret the results that are found. The present project aims to close this gap by applying new research methodologies and theoretical insights based on our previous research.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0560916
Funder
Australian Research Council
Funding Amount
$323,400.00
Summary
Magnetic resonance in humans: Equipment for neuroscience studies. The structure, function and biochemistry of the human brain can now be assessed non-invasively using magnetic resonance (MR) techniques. A 3 Tesla MR facility with half its time available for research has recently been established at POWMRI. This application seeks state-of-the-art equipment so that the facility can optimise its research potential and enhance its scientific output. Research is directed to understanding how the nor ....Magnetic resonance in humans: Equipment for neuroscience studies. The structure, function and biochemistry of the human brain can now be assessed non-invasively using magnetic resonance (MR) techniques. A 3 Tesla MR facility with half its time available for research has recently been established at POWMRI. This application seeks state-of-the-art equipment so that the facility can optimise its research potential and enhance its scientific output. Research is directed to understanding how the normal brain functions, how deficits in function develop, and how the function and structure of the brain change with age. This grant will help establish an internationally-competitive, broadly-based facility which is dedicated to understanding the human brain.Read moreRead less
Cellular Plasticity in the Brain: discovering molecular mechanisms controlling the production of neurons during brain development, function, ageing and disease. The program aims to understand the mechanisms regulating Brain Plasticity - this recently discovered property of the brain to respond to environmental stimuli, both physiological and pathological, by producing new functional neurons. Specifically, the program will discover how the brain's stem cells are stimulated to produce new neurons. ....Cellular Plasticity in the Brain: discovering molecular mechanisms controlling the production of neurons during brain development, function, ageing and disease. The program aims to understand the mechanisms regulating Brain Plasticity - this recently discovered property of the brain to respond to environmental stimuli, both physiological and pathological, by producing new functional neurons. Specifically, the program will discover how the brain's stem cells are stimulated to produce new neurons. This understanding will significantly expand our knowledge of how the brain develops, and how functions, like memory, are modulated by neuronal replacement. Discoveries will underpin the development of, in association with Australia's biotechnology sector, a new generation of therapeutics, which treat neurological diseases, like Stroke, by stimulating the production of functional neurons.Read moreRead less
The language abilities of young offenders: Missing links in theory and practice.. Young offenders are a complex and challenging population, with high rates of comorbidity between attentional, learning, and behaviour problems. Few workers have, however, considered the underlying language processing and production skills in this population. Available evidence indicates a high level of vulnerability to language disorders in young offenders. These may contribute to poor academic performance and fail ....The language abilities of young offenders: Missing links in theory and practice.. Young offenders are a complex and challenging population, with high rates of comorbidity between attentional, learning, and behaviour problems. Few workers have, however, considered the underlying language processing and production skills in this population. Available evidence indicates a high level of vulnerability to language disorders in young offenders. These may contribute to poor academic performance and failure to develop prosocial skills. This study will explore language competencies and will describe their relationship to social skills, patterns of comorbidity, and type of offence (property Vs violent). Findings will be relevant to theories of juvenile offending and design of prevention/intervention programsRead moreRead less
Trauma memory and narrative structure in post-traumatic distress. The project enhances understanding of factors that maintain enduring distress and disability following traumatic experiences which have major social and financial costs to individuals, communities and to the nation. Better knowledge of these factors is central to improving early detection and refining prevention and early intervention for individuals and to help understand how communities can better manage their response to sever ....Trauma memory and narrative structure in post-traumatic distress. The project enhances understanding of factors that maintain enduring distress and disability following traumatic experiences which have major social and financial costs to individuals, communities and to the nation. Better knowledge of these factors is central to improving early detection and refining prevention and early intervention for individuals and to help understand how communities can better manage their response to severe traumatic events. The results may lead to significant refinements to efficacious psychological treatments involving exposure to emotional memories. The project's innovative approach to studying autobiographical memories will enhance Australia's internationally competitiveness in a key area within psychology.Read moreRead less
Parents as Partners: Getting children off to a healthy start in literacy. Our nation is best served by children getting off to a healthy start in literacy. However, almost one in six children fails to do so. This group has reduced academic and vocational options, increased social, emotional and mental health problems, higher youth unemployment, and is significantly over-represented among offenders. The nation bears the costs of these problems through reduced productivity and expenditure on unemp ....Parents as Partners: Getting children off to a healthy start in literacy. Our nation is best served by children getting off to a healthy start in literacy. However, almost one in six children fails to do so. This group has reduced academic and vocational options, increased social, emotional and mental health problems, higher youth unemployment, and is significantly over-represented among offenders. The nation bears the costs of these problems through reduced productivity and expenditure on unemployment benefits, social programs, mental health services, and incarceration. This project targets both these sources of loss to the nation by utilising a hitherto untapped community resource: Training parents of preschoolers to develop critical pre-literacy skills in their children at home before they begin to fail. Read moreRead less
Augmentation of fear extinction in anxious children through the use of D-Cycloserine. Anxiety disorders affect around a tenth of the population, including children, and produce tremendous personal and social costs. Improving our treatments for anxious children can help to prevent a lifetime of limitations and difficulties. This study will examine whether giving children a small dose of a simple antibiotic can increase the extent to which they lose their fears of specific cues when exposed to tho ....Augmentation of fear extinction in anxious children through the use of D-Cycloserine. Anxiety disorders affect around a tenth of the population, including children, and produce tremendous personal and social costs. Improving our treatments for anxious children can help to prevent a lifetime of limitations and difficulties. This study will examine whether giving children a small dose of a simple antibiotic can increase the extent to which they lose their fears of specific cues when exposed to those cues. These results have the potential to revolutionise our understanding and treatment of child anxiety.Read moreRead less
The associative mechanisms underlying extinction and latent inhibition. Formal models that explain how animals learn associations between stimuli have enjoyed considerable success, and have even been identified with neurophysiological mechanisms. Theoretical analysis of the opposite, though equally important, form of learning - that two stimuli are not associated - lags far behind, due to fundamental methodological confounds that plague research on this topic. This project investigates two insta ....The associative mechanisms underlying extinction and latent inhibition. Formal models that explain how animals learn associations between stimuli have enjoyed considerable success, and have even been identified with neurophysiological mechanisms. Theoretical analysis of the opposite, though equally important, form of learning - that two stimuli are not associated - lags far behind, due to fundamental methodological confounds that plague research on this topic. This project investigates two instances of this learning: extinction and latent inhibition. Using a new procedure that avoids earlier confounds, we will describe and compare the processes underlying extinction and latent inhibition. This research will represent a major breakthrough in our understanding about fundamental processes in learning.Read moreRead less
A philosophical and empirical approach to the nature of perception and belief. This project offers substantial benefits - intellectual, practical, and ultimately economic - to the nation. On the intellectual side, the project will contribute to research output and will further enhance the national research strength in the study of delusions, rationality, and agency, within both philosophy of mind and inter-disciplinary cognitive science. On the practical side, the project offers the prospect of ....A philosophical and empirical approach to the nature of perception and belief. This project offers substantial benefits - intellectual, practical, and ultimately economic - to the nation. On the intellectual side, the project will contribute to research output and will further enhance the national research strength in the study of delusions, rationality, and agency, within both philosophy of mind and inter-disciplinary cognitive science. On the practical side, the project offers the prospect of considerable benefits for the community as improved theories of the nature and causes of delusions generate strategies for earlier detection or even prevention of the development of delusions, new methods of therapy for patients, and better understanding for families.Read moreRead less