An explainability oriented approach to manage dependent supply chain risks. This project aims to help supply chain companies model the impact on their operations by capturing the uncertainties impacting their upstream suppliers. In the current uncertain business environment, the project's outcome will benefit service-based industries to have an enhanced understanding of their operating environment and take decisions accordingly to avoid failures. This will significantly increase the productivity ....An explainability oriented approach to manage dependent supply chain risks. This project aims to help supply chain companies model the impact on their operations by capturing the uncertainties impacting their upstream suppliers. In the current uncertain business environment, the project's outcome will benefit service-based industries to have an enhanced understanding of their operating environment and take decisions accordingly to avoid failures. This will significantly increase the productivity of Australian service-based industries across different domains. The expected outcome is that it generates new knowledge by which risk managers of a focal company can conjointly consider risk identification/assessment with risk management analysis to develop explainable strategies for managing uncertainties. Read moreRead less
Understanding Epigenetic Modification During Oogenesis For Novel Treatments Of Female Infertility
Funder
National Health and Medical Research Council
Funding Amount
$314,644.00
Summary
Infertility affects about 10% of Australian women and the success rates of current infertility treatments are low due to our poor knowledge of eggs development. The numbers of obese and older women trying to conceive are increasing; fertility treatments are even less effective for them. I have generated mouse models to elucidate the pathways regulating egg development. I will study for alterations in these pathways in the mouse models which perfectly mimic the obesity and aging in women.
Predicting the value and use of urban land. This project aims to develop a comprehensive, robust and user-friendly set of modelling tools to predict land values more accurately. Accurate predictions of land values reduce state government revenue risks and improve resource management. The expected outcome of this project is the development of modelling tools which, can be used to study land use allocation, infrastructure delivery and government taxation revenue. This should provide significant be ....Predicting the value and use of urban land. This project aims to develop a comprehensive, robust and user-friendly set of modelling tools to predict land values more accurately. Accurate predictions of land values reduce state government revenue risks and improve resource management. The expected outcome of this project is the development of modelling tools which, can be used to study land use allocation, infrastructure delivery and government taxation revenue. This should provide significant benefits such as the development of new econometric theory, advanced computational methods and evidence-based guidelines for policymakers.Read moreRead less
Identifying Novel Lipid And Genetic Signatures Of Metabolic Disease In Early Childhood
Funder
National Health and Medical Research Council
Funding Amount
$354,592.00
Summary
Both our genetic makeup and environment can contribute to the development of obesity, diabetes and heart disease. Although onset usually occurs in adulthood, the progression towards disease can start in early life. Early childhood represents an opportunity for intervention to avoid adverse health outcomes in adulthood. This proposal combines two established birth cohorts from Singapore (GUSTO) and Australia (BIS) to examine the genetic and environmental origins of metabolic diseases.
Improving Physical Health Outcomes For Young People With Psychotic Disorders
Funder
National Health and Medical Research Council
Funding Amount
$189,384.00
Summary
Enduring psychotic disorders are associated with a reduced life expectancy by 25 years, which is mainly due to cardiovascular disease. This project will produce a training package that will improve clinician’s skills and knowledge of screening and treatment for physical health risk factors in young people with psychosis. This project will result in the development of an intervention for reducing the prevalence of these cardiovascular risk factors known to contribute to this early mortality.
The Management To Optimise Diabetes And MEtabolic Syndrome Risk Reduction Via Nurse-led Intervention (MODERN) Study
Funder
National Health and Medical Research Council
Funding Amount
$1,445,861.00
Summary
There is increasing recognition of society’s responsibility to provide effective and sustainable health care to the entire population and not just selected parts. This practical study will test the impact of a nurse-led, multidisciplinary prevention program to reduce the risk of future cardiovascular events in middle-aged individuals at a high risk of developing cardiovascular disease (CVD) living in regional Australia.
Targeted Development Of AMPK Β2-isoform Allosteric Activators
Funder
National Health and Medical Research Council
Funding Amount
$898,147.00
Summary
Sedentary lifestyles and consumption of high energy foods has led to dramatic increases in the incidence of diseases associated with metabolic dysregulation e.g. type 2 diabetes. An attractive drug target to treat these diseases is AMP-activated protein kinase (AMPK) which functions as a cellular fuel gauge. We have discovered a new drug that crucially activates the form of AMPK found in metabolically active organs. We aim to develop this drug to unlock new therapeutic opportunity.
Targeting The Sympathetic Nervous System To Reduce The Burden Of Fatty Liver Disease
Funder
National Health and Medical Research Council
Funding Amount
$728,152.00
Summary
The metabolic syndrome is characterised by abdominal obesity, high blood pressure and an increased risk of diabetes development. It is clear from our own observations that the sympathetic nervous system (SNS) is important in the generation of obesity-related illness and, through its stimulation of the liver, plays an important role in the development of obesity-related liver disease. We will target the SNS in order to reduce the burden of obesity-related liver disease.
Early Nutrition, Epigenetics And Developmental Outcomes In Children.
Funder
National Health and Medical Research Council
Funding Amount
$550,093.00
Summary
Increasing evidence demonstrates that early nutrition, including in pregnancy, has long lasting programming effects on later health of children. Evidence implicates epigenetics (literally ‘above DNA’) in mediating these effects. The most convincing data exists for obesity and related disorders such as metabolic syndrome, diabetes, and heart disease. The focus of this project is on understanding how ‘epigenetic’ mechanisms are influencing the way our genes function to cause these disorders.