Control Of Genome Regulation And Its Role In Human Disease
Funder
National Health and Medical Research Council
Funding Amount
$419,180.00
Summary
Changes in DNA can lead to differences in susceptibility to developing many diseases. The most common mechanism by which this occurs is through changing when and in which tissues disease-relevant genes get translated into proteins. My research focuses on understanding how DNA changes result in altered gene expression and how this can affect disease susceptibility. This work requires the use of high performance computing and statistical analysis of large genome-scale datasets.
Breaking The Intergenerational Cycle Of Obesity Through Nutritional Interventions
Funder
National Health and Medical Research Council
Funding Amount
$477,180.00
Summary
The nutritional environmental experienced by an individual before birth and in early infancy is a critical determinant of their risk of obesity and assocaited metabolic disorders in later life. Over the course of this fellowship, I will focus on defining the nutritional factors which are the key drivers of this metabolic programming. My ultimate aim is to identify nutritional interventions during pregnancy and/or early infancy which can improve the long-term health outcomes of the child and redu
Short Term Effects Of Overfeeding On Metabolic Risk In Humans
Funder
National Health and Medical Research Council
Funding Amount
$380,558.00
Summary
Obesity is associated with increased risk of diabetes, heart disease and cancer. Obesity prevalence is rapidly increasing and consitutes one of the greatest threats to human health. The aim of this study is to determine mechanism-s underlying the close relationship between obesity and insulin resistance by inducing experimental weight gain in humans with and without a genetic predisposition to diabetes. This project will help identify new candidates for anti-diabetes drugs.
Progressing Life Course Research In Psychiatric Epidemiology
Funder
National Health and Medical Research Council
Funding Amount
$331,674.00
Summary
Mental health and alcohol disorders are major public health problems which cause long-term disabilities, poor health and early mortality. Addressing these problems requires a better understanding of the early factors leading to these disorders. This research program represents a unique opportunity to increase our knowledge of the origins of these disorders and significantly contribute to improved mental health and alcohol prevention policies and programs.
Long Term Progression And Pathways Of Cardiometabolic Risks For Mothers And Their Adult Offspring.
Funder
National Health and Medical Research Council
Funding Amount
$453,605.00
Summary
The aim of this research is to investigate long term postnatal outcomes of cardiovascular diseases and mortality throughout the female reproductive life course and beyond, and to study the causes, progression and pathways of metabolic syndrome, diabetes, and obesity from birth to adulthood within adult males and females.
Mechanisms Of Abnormal Expression Of The IGF2 Gene In Disorders Affectin Foetal Growth
Funder
National Health and Medical Research Council
Funding Amount
$420,872.00
Summary
The IGF2 gene is crucial for foetal growth. Only the copy inherited from the father is active, a phenomenon named parental imprinting. In some children with foetal overgrowth or growth retardation, the deregulation of imprinting of the IGF2 gene during the first days of foetal development will influence subsequent growth and will also have major implications in post-natal and adult life. We will investigate the mechanisms resulting in abnormal imprinting of IGF2 early in development.
Nutritional Epidemiology Of Cardiometabolic Risk And Mental Health Disorders From Infancy To Adulthood
Funder
National Health and Medical Research Council
Funding Amount
$443,946.00
Summary
I developed and am leading a program of nutrition research that is making a substantial difference and contribution to the literature that will eventually make a difference to the lives of children and adolescents. The focus of this work will be on the nutritional risk factors for mental health and development of the metabolic syndrome that includes cardiovascular and diabetes risk.
Pathophysiology And Therapeutics Of Lipoprotein Disorders In Humans
Funder
National Health and Medical Research Council
Funding Amount
$451,716.00
Summary
Lipid disorder is the major casual factor that contributes to the development of cardiovascular disease, the leading cause of death in Australia. My research has provided new knowledge that has significant impact upon the treatment strategy of lipid disorder and cardiovascular risk. My vision for the next four years is to develop a comprehensive program in understanding lipid transport and translating the knowledge into clinical practice.
Elucidating The Molecular Regulation Of Gp130 Complex Signalling In Lipid And Glucose Metabolism.
Funder
National Health and Medical Research Council
Funding Amount
$387,489.00
Summary
Overnutrition promotes obesity, which greatly increases the risk of type 2 diabetes and cardiovascular disease. We have provided evidence that activation of gp130 signalling may enhance insulin action and fatty acid oxidation in metabolically active tissues. My research proposal aims to elucidate the molecular regulation of gp130 complex signalling in lipid and glucose metabolism in important metabolic tissues.