Structural And Functional Studies On RNA Nuclear Retention Mediated By Paraspeckles: A Novel Gene Regulation
Funder
National Health and Medical Research Council
Funding Amount
$290,978.00
Summary
Dynamic interactions between proteins and nucleic acids are essential process in gene regulation, where aberrant regulation leads to various diseases including cancers. The project aims to examine the interactions between paraspeckle proteins and nucleic acid molecules via determination of the structures of protein-nucleic acid complexes at the atomic level. The results will provide a better understanding of a recently discovered gene regulation mechanism and a basis for new gene therapy.
Role Of IGF Binding Protein-3 (IGFBP-3) And IGFBP-5 As Modulators Of Nuclear Hormone Signalling
Funder
National Health and Medical Research Council
Funding Amount
$465,750.00
Summary
The insulin-like growth factors are small proteins involved in the growth of most tissues. Their actions are regulated by binding to larger proteins (known as IGFBPs) in the bloodstream and outside the cell. However, some IGFBPs are also found inside cells, where they seem to carry out other functions. We believe that two of these binding proteins, IGFBP-3 and IGFBP-5, change the way cells respond to vitamin A and vitamin D. These two vitamins are important in cell growth and in the way certain ....The insulin-like growth factors are small proteins involved in the growth of most tissues. Their actions are regulated by binding to larger proteins (known as IGFBPs) in the bloodstream and outside the cell. However, some IGFBPs are also found inside cells, where they seem to carry out other functions. We believe that two of these binding proteins, IGFBP-3 and IGFBP-5, change the way cells respond to vitamin A and vitamin D. These two vitamins are important in cell growth and in the way certain cells perform specialised functions. In test-tube experiments, IGFBP-3 and IGFBP-5 interact directly with the receptors that regulate the effects of these hormones. If the same thing happens inside the cell, IGFBP-3 and IGFBP-5 could change the way these receptors respond to signals from outside the cell. We will investigate what effect these IGFBPs have in living cells and in whole animals and how this may relate to human disease. If we are able to understand how IGFBP-3 and IGFBP-5 affect the way cells respond to vitamin A and D, then we may be able to develop new ways to treat certain human diseases.Read moreRead less
Alpha-2-Macroglobulin And The Transport And Uptake Of The Hormone, Hepcidin
Funder
National Health and Medical Research Council
Funding Amount
$533,541.00
Summary
Hepcidin is a peptide hormone that is a major regulator of iron metabolism. It has been suggested that hepcidin is free in the blood. However, we recently identified that hepcidin binds with alpha-2-macroglobulin (a2-M) in the plasma and this increases the efficacy of this peptide. The demonstration that a2-M plays a role in hepcidin biology will lead to a better understanding of hepcidin physiology, the development of methods for its measurement and improved treatment of iron related diseases.
Design of Cost-effective Compositionally Complex Alloys. This project aims to develop low-cost and corrosion resistant compositionally complex alloys and associated processes to concurrently achieve high strength and high toughness using an innovative design strategy. The project expects to overcome the major limitations of this new type of alloys, enabling their practical applications in industry, creating new knowledge of materials science. Expected outcomes include commercialisation ready ne ....Design of Cost-effective Compositionally Complex Alloys. This project aims to develop low-cost and corrosion resistant compositionally complex alloys and associated processes to concurrently achieve high strength and high toughness using an innovative design strategy. The project expects to overcome the major limitations of this new type of alloys, enabling their practical applications in industry, creating new knowledge of materials science. Expected outcomes include commercialisation ready new alloys, breakthrough fundamental understanding of the mechanisms and long-term institutional collaboration. This should provide significant benefits, such as enhancement of Australia’s capacity of alloy development and manufacturing and strengthening the country’s world leading position in this area.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE160100357
Funder
Australian Research Council
Funding Amount
$345,000.00
Summary
Ultrastable metallic glasses. The aim of this project is to create a new class of amorphous alloy – ultrastable metallic glass – by a relatively simple vapour-deposition route. These materials are expected to exhibit unprecedentedly low energy states and properties of high thermal stability, elastic modulus, strength, and hardness not achievable in metallic glasses produced by conventional routes. These new materials may also provide a platform for addressing the longstanding issues of relaxatio ....Ultrastable metallic glasses. The aim of this project is to create a new class of amorphous alloy – ultrastable metallic glass – by a relatively simple vapour-deposition route. These materials are expected to exhibit unprecedentedly low energy states and properties of high thermal stability, elastic modulus, strength, and hardness not achievable in metallic glasses produced by conventional routes. These new materials may also provide a platform for addressing the longstanding issues of relaxation dynamics in glassy physics. The unique properties of ultrastable metallic glasses are expected to make them useful in a range of applications, including highly wear- and corrosion-resistant coatings on electronics and biomedical devices and components.Read moreRead less
The design of new die-castable bulk metallic glasses exhibiting superior mechanical performance. The most dramatic illustration of non-equilibrium processing of a metal is the formation of an amorphous solid that can possess physical and/or functional properties superior to its equilibrium crystalline counterpart. This project will generate new types of net-shape-processed amorphous alloys with an excellent combination of properties.
A new class of poly-amorphous alloy exhibiting outstanding damage tolerance. The most dramatic illustration of non-equilibrium processing of a metal is the formation of an amorphous solid that can possess physical and/or functional properties superior to its equilibrium crystalline counterpart. This project will generate a new class of highly processable amorphous metal with an unusual combination of mechanical properties.
Discovery And Mechanisms Of Host Cell Factors In HIV Uncoating
Funder
National Health and Medical Research Council
Funding Amount
$635,098.00
Summary
HIV entry into the host cell involves release of its capsid, a protein shell protecting the viral genome. The capsid hijacks host proteins to cloak itself from cellular defenses while the cell has evolved sensors that can block viral infection. This proposal aims to discover proteins involved in this arms race between host and virus and decipher how they control capsid disassembly. This insight will help design new drugs against HIV infection and new ways to deliver genes for gene therapies.
Ultra-lightweight alloys with unique multi-dimensional property profiles. Lightweight alloys with high specific-strength are an essential prerequisite in modern and future technologies. To be useful, they must also possess ductility and inherent corrosion resistance. The latter two properties, however, are inversely correlated with strength. This project proposes to break this paradox - not only in terms of a paradigm change regarding multi-property alloy design - but as applied to the most ligh ....Ultra-lightweight alloys with unique multi-dimensional property profiles. Lightweight alloys with high specific-strength are an essential prerequisite in modern and future technologies. To be useful, they must also possess ductility and inherent corrosion resistance. The latter two properties, however, are inversely correlated with strength. This project proposes to break this paradox - not only in terms of a paradigm change regarding multi-property alloy design - but as applied to the most lightweight engineering alloy system in existence, Magnesium-Lithium (Mg-Li), for which the impact on specific properties is immense. The aim is to develop ultra-lightweight Mg-Li based alloys with formidable property profiles via alloy design and thermomechanical processing. The expected outcome is a new class of structural corrosion resistant metal.Read moreRead less
Crystallography to deform and anneal metals. This project aims to study how the micromechanisms of plastic deformation affect the annealing behaviour of metals. This project will create a computational platform built on a reconstruction algorithm for three-dimensionally reconstructing experimentally-derived orientation data to generate the complete microstructure of crystalline material. It will reconstruct complex deformation and recrystallising structures in metals, through to the boundaries, ....Crystallography to deform and anneal metals. This project aims to study how the micromechanisms of plastic deformation affect the annealing behaviour of metals. This project will create a computational platform built on a reconstruction algorithm for three-dimensionally reconstructing experimentally-derived orientation data to generate the complete microstructure of crystalline material. It will reconstruct complex deformation and recrystallising structures in metals, through to the boundaries, phases and interfaces present in metals and ceramics. The intended outcome is the explanation of unresolved phenomena associated with thermomechanical processing of metals and alloys, useful for materials science, structural geology and condensed matter physics.Read moreRead less