Urotensin-II In Human Heart: Investigation Of Mechanisms Involved In Cardiac Function
Funder
National Health and Medical Research Council
Funding Amount
$255,990.00
Summary
The normal function of the body is maintained by naturally occurring compounds. Some for example affect the heart, fine tuning it to make it beat faster or slower, or beat with greater or less force when required in different situations in health and disease. We were the first to show just recently that a small protein which occurs naturally in the body, called urotensin-II can affect the way the heart beats. We showed that extremely tiny amounts increase the force of the heart beat. Our finding ....The normal function of the body is maintained by naturally occurring compounds. Some for example affect the heart, fine tuning it to make it beat faster or slower, or beat with greater or less force when required in different situations in health and disease. We were the first to show just recently that a small protein which occurs naturally in the body, called urotensin-II can affect the way the heart beats. We showed that extremely tiny amounts increase the force of the heart beat. Our findings indicate that urotensin-II is the most potent heart stimulator identified to date. In patients with heart failure, short term stimulation of heart contraction is beneficial, supplying the heart and other organs with vital oxygen and nutrients. However, in the long term excessive stimulation causes worsening of the patients condition. Very little is currently known about the way in which urotensin-II alters heart function. The goal of our study is to understand the mechanism involved in urotensin-II mediated effects on the heart. This will involve identifying the location of urotensin-II and its receptors in the heart, and determining what signalling changes occur after the interaction of urotensin-II with its receptors. Urotensin-II must first be cleaved from a larger drug. We will determine where in the heart this cleavage occurs and whether the process is crucial to the ability of urotensin-II to stimulate contraction of the heart. Since stimulators of heart contraction are detrimental to patients with heart failure in the long term, we will determine whether these patients have more urotensin-II in their blood than patients who do not have heart failure. If the levels of urotensin-II are higher in heart failure patients, it may indicate a need to interfere with the interaction of urotensin-II with its receptors.Read moreRead less
Designing Gender Equality into the Future of Work. This project aims to investigate how women and men understand and experience the changing nature of work and their hopes and fears for the future. This project expects to generate new knowledge about the gendered dimensions of workplace change using an innovative and engaged research design that focuses on retail and the law, two areas where women are increasingly dominant, but which are located at distinct ends of the labour market. Expected ....Designing Gender Equality into the Future of Work. This project aims to investigate how women and men understand and experience the changing nature of work and their hopes and fears for the future. This project expects to generate new knowledge about the gendered dimensions of workplace change using an innovative and engaged research design that focuses on retail and the law, two areas where women are increasingly dominant, but which are located at distinct ends of the labour market. Expected outcomes of this project include an enhanced and coordinated capacity to build gender equality into the future of work. This should provide significant benefits such as better living standards for individuals and families and improved profitability and productivity for businesses. Read moreRead less
Towards a School-Community Based Approach to Addressing Student Absenteeism. This project aims to develop an integrated school-community approach to assist education systems to effectively address student absenteeism in marginalised communities. Excessive absenteeism is linked to low academic achievement and school dropout, which limits young people’s life opportunities and perpetuates social disadvantage. This project will use interdisciplinary methods to bring the experiences of schools and co ....Towards a School-Community Based Approach to Addressing Student Absenteeism. This project aims to develop an integrated school-community approach to assist education systems to effectively address student absenteeism in marginalised communities. Excessive absenteeism is linked to low academic achievement and school dropout, which limits young people’s life opportunities and perpetuates social disadvantage. This project will use interdisciplinary methods to bring the experiences of schools and communities, existing research evidence, and academics together to enable schools to work in new ways to improve attendance. Expected outcomes will be enhanced capacity of schools to address absenteeism with the benefit of assisting the government to alleviate the societal and economic costs of this enduring problem.Read moreRead less
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Discovery Early Career Researcher Award - Grant ID: DE120101206
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Offending across the life-course: testing developmental and life-course theories of crime. There are many different explanations for why people start and stop offending. This project will draw on a range of Australian and international data to determine which explanations provide the most accurate description of why people engage in offending and the processes which lead offenders to stop offending.
Addressing food insecurity through participatory social enterprise. This project aims to address food insecurity by assisting vulnerable populations to participate in the development of new food businesses. The project is expected to empower individuals and communities and create new economic development opportunities. The social and economic benefits of this project includes increased access to food, greater participation in new food enterprises and an improved quality of life for vulnerable pe ....Addressing food insecurity through participatory social enterprise. This project aims to address food insecurity by assisting vulnerable populations to participate in the development of new food businesses. The project is expected to empower individuals and communities and create new economic development opportunities. The social and economic benefits of this project includes increased access to food, greater participation in new food enterprises and an improved quality of life for vulnerable people experiencing food insecurity in Australia.Read moreRead less
Community variations in crime: A spatial and ecometric analysis. Collective Efficacy (CE) is a new theoretical construct (that has never been investigated in Australia). It is a task-specific process for mobilising social capital to tackle specific neighbourhood problems. Research in Chicago finds that communities with high levels of CE experience lower levels of violence regardless of poverty levels. We will conduct a spatial and ecometric analysis of CE and crime using a survey of 3000 residen ....Community variations in crime: A spatial and ecometric analysis. Collective Efficacy (CE) is a new theoretical construct (that has never been investigated in Australia). It is a task-specific process for mobilising social capital to tackle specific neighbourhood problems. Research in Chicago finds that communities with high levels of CE experience lower levels of violence regardless of poverty levels. We will conduct a spatial and ecometric analysis of CE and crime using a survey of 3000 residents in 50 Brisbane communities. We will compare similar data from Chicago and Stockholm to investigate the Australian contribution of CE to spatial crime patterns and its potential for future crime prevention programs.Read moreRead less
The high cost of financial insecurity: exploring the role of the 'fringe economy' in the lives of low-income Australians. The national benefit from this research has a number of dimensions. The first is to draw the community's attention to the high costs and charges associated with fringe lenders in Australia and the economic and social consequences of accessing these services. The second benefit relates to establishing what sorts of financial products and regulatory measures would offer low-inc ....The high cost of financial insecurity: exploring the role of the 'fringe economy' in the lives of low-income Australians. The national benefit from this research has a number of dimensions. The first is to draw the community's attention to the high costs and charges associated with fringe lenders in Australia and the economic and social consequences of accessing these services. The second benefit relates to establishing what sorts of financial products and regulatory measures would offer low-income Australians a better outcome. A number of states in Australia have recently introduced legislation to limit the interest rates charged by pay-day lenders. The study is very timely in that it offers an opportunity to monitor the impact of these new regulatory measures and consider opportunities for further reform.Read moreRead less
The Kids in Communities Study: national investigation of community level effects on children's developmental outcomes. This project (a cross-disciplinary collaboration) will investigate community level factors influencing early childhood developmental outcomes using a mixed methods approach in up to 10 communities across Australia. This will result in a potential set of measures or indicators that reflect communities that are good for children.