The Unique Nature Of Gamma Delta T Cell Recognition Resolved Through Interaction With H2-Q10
Funder
National Health and Medical Research Council
Funding Amount
$699,031.00
Summary
The liver is important for both digestion and immunity. Given these opposing functions, the liver must exert control points that prevent the immune system from recognising food products. We have now identified a new molecular target that controls the development of immune cells in the liver.
Antigen Presentation, Recognition And The Immune Response
Funder
National Health and Medical Research Council
Funding Amount
$14,927,045.00
Summary
This program focuses on understanding the development of immunity during infection or inflammatory diseases using a broad array of techniques to dissect the function of various immune cell types and to explore the relationship between structure and function of important cell surface molecules. These studies will improve our ability to design new generation vaccines for combating infectious diseases, controlling cancer, or limiting autoimmune or inflammatory diseases.
Antigen Presentation, Recognition And The Immune Response
Funder
National Health and Medical Research Council
Funding Amount
$15,780,848.00
Summary
This program focuses on understanding the development of immune response to viruses and other infectious agents using a broad array of techniques to dissect the function of various immune cell types and to explore the relationship between structure and function of important cell surface molecules. These studies will improve our ability to design new generation vaccines for combating infectious diseases, controlling cancer, or limiting autoimmune diseases like diabetes.
Interactions Between RAGE And The Type 1 Angiotensin Receptor Determine The Pro-atherosclerotic Actions Of Angiotensin II
Funder
National Health and Medical Research Council
Funding Amount
$521,956.00
Summary
Heart attacks and strokes are a major cause of death and disability in Australians. Activation of the renin angiotensin system plays a key role in the development and progression of atherosclerosis, the process that leads to narrowing and obstruction of arteries. In preliminary data we have found a way to block these pathways without affecting the control of blood pressure. We believe that interventions based on these data will be important for the prevention and treatment of heart disease.
Unravelling The Mechanism Of MHC Class-I Associated Drug Hypersensitivities
Funder
National Health and Medical Research Council
Funding Amount
$566,308.00
Summary
Some drugs cause adverse reactions that are life threatening. We think these reactions are mediated by killer T cells as they are genetically controlled by immune response genes that normally guide immunity to microbes. We will study immune reactions to the drug abacavir, used to treat HIV (AIDS); allopurinol used to prevent gout and carbamazepine, used to treat epilepsy. The study may also help devise better treatments for patients who experience severe forms of these reactions.
Ending long-term homelessness permanently: How to make effective links between housing and long-term support. Australian services for homeless people typically provide short to medium-term assistance and accommodation. This approach struggles to meet the complex needs of the long-term homeless. Recently there has been considerable government investment in new approaches to end long-term homelessness, but evidence supporting the efficacy of these approaches is limited. This project builds on a fo ....Ending long-term homelessness permanently: How to make effective links between housing and long-term support. Australian services for homeless people typically provide short to medium-term assistance and accommodation. This approach struggles to meet the complex needs of the long-term homeless. Recently there has been considerable government investment in new approaches to end long-term homelessness, but evidence supporting the efficacy of these approaches is limited. This project builds on a four year Randomised Controlled Trial of the Journey to Social Inclusion pilot-program which was designed to end long-term homelessness. The project aims to track participants for an additional two years. The research aims to provide new knowledge on what practices and factors generate positive outcomes and what factors and practices sustain positive outcomes.Read moreRead less
Hunger for Change: Student Food Insecurity and Youth Agency in Australia. Rising food prices threaten to exacerbate an already pressing problem of food insecurity among students in Australia universities. This project will examine the causes, consequences, and nature of food insecurity among students in Australia employing interviews, focus groups and participant observation. It will contribute to scholarly debates on food security and youth agency through highlighting the imaginative ways in wh ....Hunger for Change: Student Food Insecurity and Youth Agency in Australia. Rising food prices threaten to exacerbate an already pressing problem of food insecurity among students in Australia universities. This project will examine the causes, consequences, and nature of food insecurity among students in Australia employing interviews, focus groups and participant observation. It will contribute to scholarly debates on food security and youth agency through highlighting the imaginative ways in which young people are developing responses to food insecurity. The project will offer the Australian government, State governments and universities opportunities to build upon student-led solutions to food insecurity, enhance capacity for research on food and youth issues, and heighten public understanding of the issue.Read moreRead less
Families at the centre: negotiating Australia's mixed market in early education and care. Despite a surge of policy reforms and Australian government investment in early childhood education and care (ECEC), little is known in Australia about how local ECEC markets function and how low-income families make decisions about the use or non-use of child care services. This project will provide evidence for policy-making and service provision that aims to encourage child care use by low-income familie ....Families at the centre: negotiating Australia's mixed market in early education and care. Despite a surge of policy reforms and Australian government investment in early childhood education and care (ECEC), little is known in Australia about how local ECEC markets function and how low-income families make decisions about the use or non-use of child care services. This project will provide evidence for policy-making and service provision that aims to encourage child care use by low-income families. The direct involvement of child care providers in the research will strengthen its relevance and impact. This research will place Australia at the forefront of international research on local child care markets, and resulting improvements in ECEC policy and services will generate substantial economic and social benefits.Read moreRead less
Breaking the cycle: the role of housing and support in resolving chronic homelessness. The Australian Government aims to reduce homelessness by half by 2020 and to offer supported accommodation to all rough sleepers by 2020. Chronically homeless people are often part of an impoverished underclass, largely excluded from the labour force and other mainstream institutions. This research will lead to improvements in service delivery and program designs and will link them to the wider areas of housi ....Breaking the cycle: the role of housing and support in resolving chronic homelessness. The Australian Government aims to reduce homelessness by half by 2020 and to offer supported accommodation to all rough sleepers by 2020. Chronically homeless people are often part of an impoverished underclass, largely excluded from the labour force and other mainstream institutions. This research will lead to improvements in service delivery and program designs and will link them to the wider areas of housing policy and social inclusion. The findings will directly contribute to the National Research Priority, promoting and maintaining good health and the priority goal strengthening Australia's social and economic fabric.Read moreRead less