Exploring The Function Of Breast Cancer-Associated Variants In Long Non-Coding RNAs
Funder
National Health and Medical Research Council
Funding Amount
$501,585.00
Summary
Recent studies have identified regions within the human genome in which DNA sequence variations are associated with an increased risk of breast cancer. Several of these regions do not contain any known protein coding genes, suggesting that non-protein coding genes could be responsible for the associated risk. The aim of this proposal is to identify and characterise these non-coding genes. Understanding how sequences variations in these novel genes contribute to breast cancer will provide novel a ....Recent studies have identified regions within the human genome in which DNA sequence variations are associated with an increased risk of breast cancer. Several of these regions do not contain any known protein coding genes, suggesting that non-protein coding genes could be responsible for the associated risk. The aim of this proposal is to identify and characterise these non-coding genes. Understanding how sequences variations in these novel genes contribute to breast cancer will provide novel avenues for therapy.Read moreRead less
Status seeking and economic behaviour. The project will look at the importance of status seeking behaviour for the health system, behavioural experiments, international growth, and labelling. The insights will be useful for optimal redistribution policies, international cooperation, and behavioural research.
Understanding Dynamic Aspects of Economic Inequality. This project aims to study dynamic aspects of inequality in Australia by exploring the changes in labour and housing market conditions and their relation to the changes in the distribution of income and wealth over the last decade. The project also aims to develop new econometric techniques to examine the factors that are responsible for the changes in the distribution of income and wealth and a range of labour and housing market outcomes. Pa ....Understanding Dynamic Aspects of Economic Inequality. This project aims to study dynamic aspects of inequality in Australia by exploring the changes in labour and housing market conditions and their relation to the changes in the distribution of income and wealth over the last decade. The project also aims to develop new econometric techniques to examine the factors that are responsible for the changes in the distribution of income and wealth and a range of labour and housing market outcomes. Particular attention will be paid to the role of the changes in individual-specific characteristics (such as education, age, employment status, and occupation) and neighbourhood-specific characteristics (such as house prices and population ageing) in producing inequality.Read moreRead less
Gene Expression Profiling In Critically Ill Patients With Septic Shock: The ADRENAL-GEPS Study
Funder
National Health and Medical Research Council
Funding Amount
$863,304.00
Summary
Sepsis refers to a whole body inflammation caused by severe infection. Approximately one in three adults admitted with septic shock die within 28 days and it is unclear whether treatment with anti-inflammatory drugs is beneficial in terms of patient survival. The aim of this study is to develop a clinical test based on gene activity that can be used to predict patient survival and also determine what the best treatment might be for individual patients.
Identifying Novel Long-noncoding RNAs Involved In The Development Of Breast Cancer
Funder
National Health and Medical Research Council
Funding Amount
$785,204.00
Summary
Recent studies have identified regions within the human genome in which DNA sequence variations are associated with an increased risk of breast cancer. The aim of this proposal is to identify and characterise these non-coding genes that are modulate breast cancer risk. Understanding how sequences variations that alter these novel genes contribute to breast cancer will provide novel avenues for therapy.
Incentivizing Attendance and Performance at School: A Field Experiment. This project aims to develop and evaluate an incentive-based program to increase the school attendance and performance of Indigenous students to help alleviate current inequalities between Indigenous and non-indigenous Australians. Only 43 per cent of Indigenous Australians graduate from high school compared to 78 per cent for non-Indigenous Australians. The study plans to investigate whether high value rewards (e.g. driving ....Incentivizing Attendance and Performance at School: A Field Experiment. This project aims to develop and evaluate an incentive-based program to increase the school attendance and performance of Indigenous students to help alleviate current inequalities between Indigenous and non-indigenous Australians. Only 43 per cent of Indigenous Australians graduate from high school compared to 78 per cent for non-Indigenous Australians. The study plans to investigate whether high value rewards (e.g. driving licence instruction) are effective in incentivising year 11 and 12 students. It also aims to examine whether the way incentives are provided — ex-post as traditionally done or ex-ante in the form of a trust-based contract — increase high school completion rates of Indigenous students where previous incentive schemes have failed.Read moreRead less
ARC Centre of Excellence in Population Ageing Research. This Centre intends to generate crucial knowledge to inform social and economic responses to population ageing, one of the most important issues of the 21st century. Population ageing exerts unprecedented pressures on social norms and policy institutions, both in Australia and around the world. Leading researchers from a range of disciplines will undertake multidisciplinary research to help governments, businesses, and consumers prepare for ....ARC Centre of Excellence in Population Ageing Research. This Centre intends to generate crucial knowledge to inform social and economic responses to population ageing, one of the most important issues of the 21st century. Population ageing exerts unprecedented pressures on social norms and policy institutions, both in Australia and around the world. Leading researchers from a range of disciplines will undertake multidisciplinary research to help governments, businesses, and consumers prepare for and make better decisions for an ageing world, with consequent social and economic benefits for families and communities expected to flow to Australia, the Asian region and the world.Read moreRead less
Making Music Work: Sustainable Portfolio Careers for Australian Musicians. This project plans to explore the conditions and strategies needed for musicians to sustain successful portfolio careers. Most musicians have ‘portfolio careers’, combining aspects of performance, recording, creation, music direction, teaching, community activities, health, retail and a presence in online environments. This phenomenon — often across music genres — is widespread but not well understood. The project involve ....Making Music Work: Sustainable Portfolio Careers for Australian Musicians. This project plans to explore the conditions and strategies needed for musicians to sustain successful portfolio careers. Most musicians have ‘portfolio careers’, combining aspects of performance, recording, creation, music direction, teaching, community activities, health, retail and a presence in online environments. This phenomenon — often across music genres — is widespread but not well understood. The project involves surveys and 12 in-depth case studies of individual musicians or ensembles that will aim to identify key success factors and obstacles. This information is intended to inform opportunities for training, development and support.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE240100408
Funder
Australian Research Council
Funding Amount
$446,411.00
Summary
Advancing bioelectronics with silicon carbide on microfluidics. Flexible bioelectronics is an emerging technology for real-time monitoring of vital signals on skin and in the body. Microfluidics is a technology for fluid handling in microscale. This project aims to develop the first platform technology with both flexible bioelectronics and microfluidics for enhanced sensing, thermal management and actuation. The project is expected to establish new fundamental knowledge in sensitivity boosting m ....Advancing bioelectronics with silicon carbide on microfluidics. Flexible bioelectronics is an emerging technology for real-time monitoring of vital signals on skin and in the body. Microfluidics is a technology for fluid handling in microscale. This project aims to develop the first platform technology with both flexible bioelectronics and microfluidics for enhanced sensing, thermal management and actuation. The project is expected to establish new fundamental knowledge in sensitivity boosting mechanisms with nano-thin semiconducting films, practical prototypes for long-lasting bioelectronics with integrated microfluidics and their large-scale manufacturing processes. Outcomes include step changes in designing innovative wearable and implantable devices and their massive commercialisation opportunities.Read moreRead less
Non-viral Vectors For Targeted Delivery Of RNAi Nucleotides To Cervical Cancers
Funder
National Health and Medical Research Council
Funding Amount
$415,738.00
Summary
RNA interference (or gene silencing) is a new technique whereby we are able to turn off the expression of a particular gene either temporarily or permanently. Cancer is basically a genetic disease where certain protective genes are lost or cancer-causing genes expressed. Gene silencing holds great promise in the treatment of genetic disorders, infectious diseases and cancer. Cervical cancer is caused by infection with the human papillomavirus and the expression of two cancer-causing genes. Using ....RNA interference (or gene silencing) is a new technique whereby we are able to turn off the expression of a particular gene either temporarily or permanently. Cancer is basically a genetic disease where certain protective genes are lost or cancer-causing genes expressed. Gene silencing holds great promise in the treatment of genetic disorders, infectious diseases and cancer. Cervical cancer is caused by infection with the human papillomavirus and the expression of two cancer-causing genes. Using RNA interference we can turn off the expression of these two genes which results in the death of the cancer cell. We are also able to cure mice of tumours derived from human cervical cancer. The major issue with gene silencing is how to deliver it effectively to patients. Here we are investigating novel nanoparticulate systems to deliver this new gene-inhibiting drugs preferentially to the tumour site.Read moreRead less