Structural And Functional Studies On RNA Nuclear Retention Mediated By Paraspeckles: A Novel Gene Regulation
Funder
National Health and Medical Research Council
Funding Amount
$290,978.00
Summary
Dynamic interactions between proteins and nucleic acids are essential process in gene regulation, where aberrant regulation leads to various diseases including cancers. The project aims to examine the interactions between paraspeckle proteins and nucleic acid molecules via determination of the structures of protein-nucleic acid complexes at the atomic level. The results will provide a better understanding of a recently discovered gene regulation mechanism and a basis for new gene therapy.
Living on the Margin: The Relationship between Mental Health and Work in Australia. This project will assess the relationship between Australians' mental health and their work, for example, employment status, work conditions and hours. The study is the first to exploit the detailed timing of mental health and employment transitions to identify whether poor labour market outcomes lead to poor mental health or whether the reverse is true. New Australian data will be used to understand whether the ....Living on the Margin: The Relationship between Mental Health and Work in Australia. This project will assess the relationship between Australians' mental health and their work, for example, employment status, work conditions and hours. The study is the first to exploit the detailed timing of mental health and employment transitions to identify whether poor labour market outcomes lead to poor mental health or whether the reverse is true. New Australian data will be used to understand whether the link between mental health and work adds to the economic vulnerability of families and those at risk of homelessness. The results will advance our understanding of the way that mental health affects overall economic well-being and will inform current policy initiatives to promote economic participation and good mental health.Read moreRead less
Understanding The Role Of RAS Mutations In Thyroid Cancer.
Funder
National Health and Medical Research Council
Funding Amount
$463,854.00
Summary
My fellowship will examine the association of RAS mutations in thyroid cancer. RAS proteins are the most mutated in cancer and I will investigate how they work in thyroid cancer. RAS mutated thyroid cancer is more likely to cause death. This grant will be based in the pioneering lab of Prof Fagin at Memorial Sloan Kettering Cancer Center and the Garvan Institute of Medical Research. It is hoped by understanding these mutations, new treatments for thyroid cancer can be developed.
Human Capital, Cognitive Skills and Labour Market Outcomes. As Australia competes in the ‘educational race,’ this project will generate new knowledge on the relationship between education, skill attainment and economic outcomes in Australia. The research will provide new empirical evidence on cognitive and non-cognitive skills formation over the life-cycle, and the relationship between these skills and labour market outcomes in Australia within the broader international context. The research wil ....Human Capital, Cognitive Skills and Labour Market Outcomes. As Australia competes in the ‘educational race,’ this project will generate new knowledge on the relationship between education, skill attainment and economic outcomes in Australia. The research will provide new empirical evidence on cognitive and non-cognitive skills formation over the life-cycle, and the relationship between these skills and labour market outcomes in Australia within the broader international context. The research will advance methodological techniques for the economic analysis of cognitive skills and their economic impacts. The research will inform public policy formulation relating to educational attainment, skill development, and strategies to encourage longer workforce engagement over the life-cycle.Read moreRead less
Incentivizing Attendance and Performance at School: A Field Experiment. This project aims to develop and evaluate an incentive-based program to increase the school attendance and performance of Indigenous students to help alleviate current inequalities between Indigenous and non-indigenous Australians. Only 43 per cent of Indigenous Australians graduate from high school compared to 78 per cent for non-Indigenous Australians. The study plans to investigate whether high value rewards (e.g. driving ....Incentivizing Attendance and Performance at School: A Field Experiment. This project aims to develop and evaluate an incentive-based program to increase the school attendance and performance of Indigenous students to help alleviate current inequalities between Indigenous and non-indigenous Australians. Only 43 per cent of Indigenous Australians graduate from high school compared to 78 per cent for non-Indigenous Australians. The study plans to investigate whether high value rewards (e.g. driving licence instruction) are effective in incentivising year 11 and 12 students. It also aims to examine whether the way incentives are provided — ex-post as traditionally done or ex-ante in the form of a trust-based contract — increase high school completion rates of Indigenous students where previous incentive schemes have failed.Read moreRead less
Making Music Work: Sustainable Portfolio Careers for Australian Musicians. This project plans to explore the conditions and strategies needed for musicians to sustain successful portfolio careers. Most musicians have ‘portfolio careers’, combining aspects of performance, recording, creation, music direction, teaching, community activities, health, retail and a presence in online environments. This phenomenon — often across music genres — is widespread but not well understood. The project involve ....Making Music Work: Sustainable Portfolio Careers for Australian Musicians. This project plans to explore the conditions and strategies needed for musicians to sustain successful portfolio careers. Most musicians have ‘portfolio careers’, combining aspects of performance, recording, creation, music direction, teaching, community activities, health, retail and a presence in online environments. This phenomenon — often across music genres — is widespread but not well understood. The project involves surveys and 12 in-depth case studies of individual musicians or ensembles that will aim to identify key success factors and obstacles. This information is intended to inform opportunities for training, development and support.Read moreRead less
Humanitarian immigrant entrepreneurs in private and social enterprises. The project aims to provide, for the first time, a detailed understanding of the experiences of male and female humanitarian immigrant entrepreneurs in private and social enterprises in urban and regional Australia, and critically evaluate how these entrepreneurs help redress the settlement problems and socio-economic disadvantage of humanitarian immigrants and contribute to economic growth and social cohesion in Australia. ....Humanitarian immigrant entrepreneurs in private and social enterprises. The project aims to provide, for the first time, a detailed understanding of the experiences of male and female humanitarian immigrant entrepreneurs in private and social enterprises in urban and regional Australia, and critically evaluate how these entrepreneurs help redress the settlement problems and socio-economic disadvantage of humanitarian immigrants and contribute to economic growth and social cohesion in Australia. One key aim will be to further develop the theory of Diasporic entrepreneurship. The benefits are expected to include an evaluation of effective strategies and policies to improve existing humanitarian immigrant enterprises and to stimulate the creation of new humanitarian immigrant enterprises.Read moreRead less
ARC Centre of Excellence in Population Ageing Research. The Centre aims to execute world class basic and applied research to transform our capacity to respond to the economic and social challenges of demographic change, and to changes in individual longevity and cognitive and motor capacity. It will combine in-house expertise with leading researchers globally in initiatives to generate new outcome-oriented approaches to studying the population ageing process and its implications. It s research w ....ARC Centre of Excellence in Population Ageing Research. The Centre aims to execute world class basic and applied research to transform our capacity to respond to the economic and social challenges of demographic change, and to changes in individual longevity and cognitive and motor capacity. It will combine in-house expertise with leading researchers globally in initiatives to generate new outcome-oriented approaches to studying the population ageing process and its implications. It s research will inform innovative policy formulation and product and market development, and train a new generation of researchers into population ageing with an enriched appreciation of the cross-disciplinary dimensions of population ageing research.Read moreRead less
Targeting Bone Marrow Mediated Angiogenesis And Metastasis In Breast Cancer
Funder
National Health and Medical Research Council
Funding Amount
$463,006.00
Summary
Despite advances in treatment and diagnostics breast cancer (BC) remains one of the leading causes of death in women. Metastases and tumour blood vessel recruitment are linked. Work by Dr Mellick and others has shown that host bone marrow contributes endothelial progenitor cells (EPCs) to tumour vasculature. The chemokines and their receptors, which differentiate EPCs from tumour vessels, will be knocked down in the tumour cells and EPC progenitors with the aim of preventing tumour spread.
Developing sustainable retirement policy in a Chinese province: the case of Zhejiang. Much Chinese national policy has its origins in provincial initiatives, and this is especially true of retirement policy, where information about individuals is held by provinces. This project examines Zhejiang Province, one of the most innovative in policy. It promises to yield rich insights into retirement policy formulation in China.